Probing the Mutational Interplay between Primary and Promiscuous Protein Functions: A Computational-Experimental Approach

Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1

(2012) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

Sampling the Conformational Energy Landscape of a Hyperthermophilic Protein by Engineering Key Substitutions

(2012) J.-P. Colletier et al.   MOLECULAR BIOLOGY AND EVOLUTION

Multispecific Recognition: Mechanism, Evolution, and Design

(2011) Ariel Erijman et al.   BIOCHEMISTRY

The Moderately Efficient Enzyme: Evolutionary and Physicochemical Trends Shaping Enzyme Parameters

(2011) Arren Bar-Even et al.   BIOCHEMISTRY

Reactivity of Thioredoxin as a Protein Thiol-Disulfide Oxidoreductase

(2011) Zhiyong Cheng et al.   CHEMICAL REVIEWS

Active-site remodelling in the bifunctional fructose-1,6-bisphosphate aldolase/phosphatase

(2011) Juan Du et al.   NATURE

Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase

(2011) Shinya Fushinobu et al.   NATURE

A divide-and-conquer approach to determine the Pareto frontier for optimization of protein engineering experiments

(2011) Lu He et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Role of conservative mutations in protein multi-property adaptation

(2010) David Rodriguez-Larrea et al.   BIOCHEMICAL JOURNAL

What makes an enzyme promiscuous?

(2010) Ann Babtie et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A structural overview of the PDI family of proteins

(2010) Guennadi Kozlov et al.   FEBS Journal

Efficient Catalytic Promiscuity for Chemically Distinct Reactions

(2009) Ann C. Babtie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Disulfide Isomerase: A Critical Evaluation of Its Function in Disulfide Bond Formation

(2009) Feras Hatahet et al.   ANTIOXIDANTS & REDOX SIGNALING

Using multi-objective computational design to extend protein promiscuity

(2009) Maria Suarez et al.   BIOPHYSICAL CHEMISTRY

Enzyme (re)design: lessons from natural evolution and computation

(2009) John A Gerlt et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

In the light of directed evolution: Pathways of adaptive protein evolution

(2009) J. D. Bloom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Dynamism and Evolvability

(2009) N. Tokuriki et al.   SCIENCE

Disulfide-Linked Protein Folding Pathways

(2008) Bharath S. Mamathambika et al.   Annual Review of Cell and Developmental Biology

Force-Clamp Spectroscopy Detects Residue Co-evolution in Enzyme Catalysis

(2008) Raul Perez-Jimenez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pareto optimization in computational protein design with multiple objectives

(2008) María Suárez et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

Turning a hobby into a job: How duplicated genes find new functions

(2008) Gavin C. Conant et al.   NATURE REVIEWS GENETICS

A compromise required by gene sharing enables survival: Implications for evolution of new enzyme activities

(2008) S. Y. McLoughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Surface Sites for Engineering Allosteric Control in Proteins

(2008) J. Lee et al.   SCIENCE