Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme

Launching Spiking Ligands into a Protein–Protein Interface: A Promising Strategy To Destabilize and Break Interface Formation in a tRNA Modifying Enzyme

(2013) Florian Immekus et al.   ACS Chemical Biology

Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor

(2013) Inna Biela et al.   PLoS One

Modulating Protein-Protein Interactions: From Structural Determinants of Binding to Druggability Prediction to Application

(2012) Alexander Metz et al.   CURRENT PHARMACEUTICAL DESIGN

Free Energy Calculations by the Molecular Mechanics Poisson−Boltzmann Surface Area Method

(2012) Nadine Homeyer et al.   Molecular Informatics

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Chemical and structural lessons from recent successes in protein–protein interaction inhibition (2P2I)

(2011) Xavier Morelli et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Aromatic residues link binding and function of intrinsically disordered proteins

(2011) L. Michel Espinoza-Fonseca   Molecular BioSystems

HotRegion: a database of predicted hot spot clusters

(2011) E. Cukuroglu et al.   NUCLEIC ACIDS RESEARCH

Bound Water at Protein-Protein Interfaces: Partners, Roles and Hydrophobic Bubbles as a Conserved Motif

(2011) Mostafa H. Ahmed et al.   PLoS One

KFC2: A knowledge-based hot spot prediction method based on interface solvation, atomic density, and plasticity features

(2011) Xiaolei Zhu et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Protein binding hot spots and the residue-residue pairing preference: a water exclusion perspective

(2010) Qian Liu et al.   BMC BIOINFORMATICS

Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

(2010) Giovanna Zinzalla et al.   Future Medicinal Chemistry

DrugScorePPI webserver: fast and accurate in silico alanine scanning for scoring protein–protein interactions

(2010) Dennis M. Kr�ger et al.   NUCLEIC ACIDS RESEARCH

Comparing experimental and computational alanine scanning techniques for probing a prototypical protein–protein interaction

(2010) Richard T. Bradshaw et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Characterization of the human tRNA-guanine transglycosylase: Confirmation of the heterodimeric subunit structure

(2010) Y. C. Chen et al.   RNA

A survey of available tools and web servers for analysis of protein-protein interactions and interfaces

(2009) N. Tuncbag et al.   BRIEFINGS IN BIOINFORMATICS

Queuosine Formation in Eukaryotic tRNA Occurs via a Mitochondria-localized Heteromeric Transglycosylase

(2009) Coilin Boland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Integrative Approach Combining Noncovalent Mass Spectrometry, Enzyme Kinetics and X-ray Crystallography to Decipher Tgt Protein-Protein and Protein-RNA Interaction

(2009) Tina Ritschel et al.   JOURNAL OF MOLECULAR BIOLOGY

Exploring the Molecular Design of Protein Interaction Sites with Molecular Dynamics Simulations and Free Energy Calculations†

(2008) Shide Liang et al.   BIOCHEMISTRY

Small Molecule Protein–Protein Interaction Inhibitors as CNS Therapeutic Agents: Current Progress and Future Hurdles

(2008) Levi L Blazer et al.   NEUROPSYCHOPHARMACOLOGY