Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation

(2012) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations

(2012) Caitlin E. Scott et al.   PROTEIN SCIENCE

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Ligand functional selectivity and quantitative pharmacology at G protein-coupled receptors

(2011) Wayne Stallaert et al.   Expert Opinion on Drug Discovery

The Role of Conformational Ensembles in Ligand Recognition in G-Protein Coupled Receptors

(2011) Michiel J. M. Niesen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

The structural basis of agonist-induced activation in constitutively active rhodopsin

(2011) Jörg Standfuss et al.   NATURE

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Activation mechanism of the  2-adrenergic receptor

(2011) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bihelix: Towards de novo structure prediction of an ensemble of G-protein coupled receptor conformations

(2011) Ravinder Abrol et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural mechanisms of constitutive activation in the C5a receptors with mutations in the extracellular loops: Molecular modeling study

(2011) Gregory V. Nikiforovich et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Three “hotspots” important for adenosine A2B receptor activation: a mutational analysis of transmembrane domains 4 and 5 and the second extracellular loop

(2011) Miriam C. Peeters et al.   Purinergic Signalling

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine

(2011) Andrew S. Doré et al.   STRUCTURE

LCP-Tm: An Assay to Measure and Understand Stability of Membrane Proteins in a Membrane Environment

(2010) Wei Liu et al.   BIOPHYSICAL JOURNAL

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Dual Role of the Second Extracellular Loop of the Cannabinoid Receptor 1: Ligand Binding and Receptor Localization

(2009) K. H. Ahn et al.   MOLECULAR PHARMACOLOGY

Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

(2009) T. E. Angel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex

(2009) X. J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of two distinct inactive conformations of the  2-adrenergic receptor reconciles structural and biochemical observations

(2009) R. O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative models for two crystal structures of bovine rhodopsin

(2008) Ronald E. Stenkamp   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements

(2008) Victor Wai Tak Kam et al.   Journal of Chemical Theory and Computation

Constitutive Activity at the Cannabinoid CB1 Receptor Is Required for Behavioral Response to Noxious Chemical Stimulation of TRPV1: Antinociceptive Actions of CB1 Inverse Agonists

(2008) B. Fioravanti et al.   JOURNAL OF NEUROSCIENCE

Mapping the Structural Requirements in the CB1 Cannabinoid Receptor Transmembrane Helix II for Signal Transduction

(2008) A. Kapur et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of squid rhodopsin

(2008) Midori Murakami et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity

(2008) C. A. Sarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor

(2008) F. Magnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

Stabilization of the Human β2-Adrenergic Receptor TM4–TM3–TM5 Helix Interface by Mutagenesis of Glu1223.41, A Critical Residue in GPCR Structure

(2007) Christopher B. Roth et al.   JOURNAL OF MOLECULAR BIOLOGY