Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding
出版年份 2013 全文链接
标题
Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding
作者
关键词
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出版物
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Volume 81, Issue 8, Pages 1304-1317
出版商
Wiley
发表日期
2013-02-14
DOI
10.1002/prot.24264
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- (2012) Kwang H. Ahn et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations
- (2012) Caitlin E. Scott et al. PROTEIN SCIENCE
- Crystal Structure of a Lipid G Protein-Coupled Receptor
- (2012) M. A. Hanson et al. SCIENCE
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- (2011) Wayne Stallaert et al. Expert Opinion on Drug Discovery
- The Role of Conformational Ensembles in Ligand Recognition in G-Protein Coupled Receptors
- (2011) Michiel J. M. Niesen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Crystal structure of metarhodopsin II
- (2011) Hui-Woog Choe et al. NATURE
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- (2011) Jörg Standfuss et al. NATURE
- Structure of a nanobody-stabilized active state of the β2 adrenoceptor
- (2011) Søren G. F. Rasmussen et al. NATURE
- Crystal structure of the β2 adrenergic receptor–Gs protein complex
- (2011) Søren G. F. Rasmussen et al. NATURE
- Activation mechanism of the 2-adrenergic receptor
- (2011) R. O. Dror et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2011) Miriam C. Peeters et al. Purinergic Signalling
- Structure of an Agonist-Bound Human A2A Adenosine Receptor
- (2011) F. Xu et al. SCIENCE
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- International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
- (2010) R. G. Pertwee et al. PHARMACOLOGICAL REVIEWS
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- (2010) E. Y. T. Chien et al. SCIENCE
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- (2009) K. H. Ahn et al. MOLECULAR PHARMACOLOGY
- Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors
- (2009) T. E. Angel et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
- (2009) X. J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of two distinct inactive conformations of the 2-adrenergic receptor reconciles structural and biochemical observations
- (2009) R. O. Dror et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Alternative models for two crystal structures of bovine rhodopsin
- (2008) Ronald E. Stenkamp ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Flat-Bottom Strategy for Improved Accuracy in Protein Side-Chain Placements
- (2008) Victor Wai Tak Kam et al. Journal of Chemical Theory and Computation
- Constitutive Activity at the Cannabinoid CB1 Receptor Is Required for Behavioral Response to Noxious Chemical Stimulation of TRPV1: Antinociceptive Actions of CB1 Inverse Agonists
- (2008) B. Fioravanti et al. JOURNAL OF NEUROSCIENCE
- Mapping the Structural Requirements in the CB1 Cannabinoid Receptor Transmembrane Helix II for Signal Transduction
- (2008) A. Kapur et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Crystal structure of opsin in its G-protein-interacting conformation
- (2008) Patrick Scheerer et al. NATURE
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- (2008) Midori Murakami et al. NATURE
- Crystal structure of the ligand-free G-protein-coupled receptor opsin
- (2008) Jung Hee Park et al. NATURE
- Directed evolution of a G protein-coupled receptor for expression, stability, and binding selectivity
- (2008) C. A. Sarkar et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor
- (2008) F. Magnani et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2008) V.-P. Jaakola et al. SCIENCE
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- (2007) Christopher B. Roth et al. JOURNAL OF MOLECULAR BIOLOGY
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