Why is melanoma so metastatic?

Reactive Astrocytes Protect Melanoma Cells from Chemotherapy by Sequestering Intracellular Calcium through Gap Junction Communication Channels

(2015) Qingtang Lin et al.   NEOPLASIA

Polymorphonuclear Neutrophil-Derived Ectosomes Interfere with the Maturation of Monocyte-Derived Dendritic Cells

(2014) C. Eken et al.   JOURNAL OF IMMUNOLOGY

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma

(2013) D. T. Frederick et al.   CLINICAL CANCER RESEARCH

Soluble Melanoma Cell Adhesion Molecule (sMCAM/sCD146) Promotes Angiogenic Effects on Endothelial Progenitor Cells through Angiomotin

(2013) Jimmy Stalin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma

(2013) Simon J Furney et al.   JOURNAL OF PATHOLOGY

RAC1P29S is a spontaneously activating cancer-associated GTPase

(2013) M. J. Davis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

A Wnt-er Migration: The Confusing Role of  -Catenin in Melanoma Metastasis

(2013) M. R. Webster et al.   Science Signaling

The Small GTPase ARF6 Stimulates  -Catenin Transcriptional Activity During WNT5A-Mediated Melanoma Invasion and Metastasis

(2013) A. H. Grossmann et al.   Science Signaling

Lysophosphatidic Acid Induces Lymphangiogenesis and IL-8 Production in Vitro in Human Lymphatic Endothelial Cells

(2012) Hong Mu et al.   AMERICAN JOURNAL OF PATHOLOGY

RETRACTED ARTICLE: Signaling pathways in tumor vasculogenic mimicry

(2012) A. A. Vartanian   BIOCHEMISTRY-MOSCOW

Markers of circulating tumour cells in the peripheral blood of patients with melanoma correlate with disease recurrence and progression

(2012) A.L. Reid et al.   BRITISH JOURNAL OF DERMATOLOGY

Driving transcriptional regulators in melanoma metastasis

(2012) Aaron K. Mobley et al.   CANCER AND METASTASIS REVIEWS

Surgery for Distant Melanoma Metastasis

(2012) Anna M. Leung et al.   CANCER JOURNAL

Galectin-3 Contributes to Melanoma Growth and Metastasis via Regulation of NFAT1 and Autotaxin

(2012) R. R. Braeuer et al.   CANCER RESEARCH

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Expression of vascular endothelial growth factor-C in primary cutaneous melanoma predicts sentinel lymph node positivity

(2012) Francesca Cianfarani et al.   JOURNAL OF CUTANEOUS PATHOLOGY

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

(2012) Joannes FM Jacobs et al.   LANCET ONCOLOGY

Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial

(2012) Kim Margolin et al.   LANCET ONCOLOGY

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

Evolution of the cancer genome

(2012) Lucy R. Yates et al.   NATURE REVIEWS GENETICS

Lesions to right prefrontal cortex impair real-world planning through prematurecommitments

(2012) Vinod Goel et al.   NEUROPSYCHOLOGIA

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

The sweet and bitter sides of galectins in melanoma progression

(2012) Russell R. Braeuer et al.   Pigment Cell & Melanoma Research

Melanoma revives an embryonic migration program to promote plasticity and invasion

(2012) Caleb M. Bailey et al.   Pigment Cell & Melanoma Research

Tumor Cell Plasticity and Angiogenesis in Human Melanomas

(2012) Daniela Mihic-Probst et al.   PLoS One

Understanding the Melanocyte Distribution in Human Epidermis: An Agent-Based Computational Model Approach

(2012) Josef Thingnes et al.   PLoS One

Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients

(2012) Elsa Quintana et al.   Science Translational Medicine

Elucidating Distinct Roles for NF1 in Melanomagenesis

(2012) Ophélia Maertens et al.   Cancer Discovery

Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes

(2011) Kenneth L. Scott et al.   CANCER CELL

Expression of Id-1 Is Regulated by MCAM/MUC18: A Missing Link in Melanoma Progression

(2011) M. Zigler et al.   CANCER RESEARCH

Human CD271-Positive Melanoma Stem Cells Associated with Metastasis Establish Tumor Heterogeneity and Long-term Growth

(2011) G. Civenni et al.   CANCER RESEARCH

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Selective BRAF Inhibitors Induce Marked T-cell Infiltration into Human Metastatic Melanoma

(2011) James S. Wilmott et al.   CLINICAL CANCER RESEARCH

Strategies to counteract MHC-I defects in tumors

(2011) Margit H Lampen et al.   CURRENT OPINION IN IMMUNOLOGY

The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

(2011) Robert R. Langley et al.   INTERNATIONAL JOURNAL OF CANCER

Interferon-γ links ultraviolet radiation to melanomagenesis in mice

(2011) M. Raza Zaidi et al.   NATURE

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

(2011) Mitchell S Stark et al.   NATURE GENETICS

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma

(2011) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Murine Melanoma-Infiltrating Dendritic Cells Are Defective in Antigen Presenting Function Regardless of the Presence of CD4+CD25+ Regulatory T Cells

(2011) Haley Ataera et al.   PLoS One

Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis

(2011) E. S. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The secreted factors responsible for pre-metastatic niche formation: Old sayings and new thoughts

(2011) Héctor Peinado et al.   SEMINARS IN CANCER BIOLOGY

Transcriptional control of the melanoma malignant phenotype

(2010) Vladislava O. Melnikova et al.   CANCER BIOLOGY & THERAPY

Selective BRAFV600E Inhibition Enhances T-Cell Recognition of Melanoma without Affecting Lymphocyte Function

(2010) A. Boni et al.   CANCER RESEARCH

A Galectin-3 Ligand Corrects the Impaired Function of Human CD4 and CD8 Tumor-Infiltrating Lymphocytes and Favors Tumor Rejection in Mice

(2010) N. Demotte et al.   CANCER RESEARCH

Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription

(2010) Jason M. Aliotta et al.   EXPERIMENTAL HEMATOLOGY

Tumor masses support naive T cell infiltration, activation, and differentiation into effectors

(2010) Elizabeth D. Thompson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autotaxin Signaling via Lysophosphatidic Acid Receptors Contributes to Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration

(2010) M. M. Ptaszynska et al.   MOLECULAR CANCER RESEARCH

International network of cancer genome projects

(2010) Thomas J. Hudson (Chairperson) et al.   NATURE

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer stem cells versus phenotype-switching in melanoma

(2010) Keith S. Hoek et al.   Pigment Cell & Melanoma Research

CREB Inhibits AP-2α Expression to Regulate the Malignant Phenotype of Melanoma

(2010) Vladislava O. Melnikova et al.   PLoS One

Protease activated receptor-1 inhibits the Maspin tumor-suppressor gene to determine the melanoma metastatic phenotype

(2010) G. J. Villares et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Transcriptional control of melanoma metastasis: The importance of the tumor microenvironment

(2010) Russell R. Braeuer et al.   SEMINARS IN CANCER BIOLOGY

How Sunlight Causes Melanoma

(2010) Lilit Garibyan et al.   Current Oncology Reports

Host CXCR2-Dependent Regulation of Melanoma Growth, Angiogenesis, and Experimental Lung Metastasis

(2009) S. Singh et al.   CANCER RESEARCH

Overexpression of Protease-Activated Receptor-1 Contributes to Melanoma Metastasis via Regulation of Connexin 43

(2009) G. J. Villares et al.   CANCER RESEARCH

Crosstalk between Protease-activated Receptor 1 and Platelet-activating Factor Receptor Regulates Melanoma Cell Adhesion Molecule (MCAM/MUC18) Expression and Melanoma Metastasis

(2009) Vladislava O. Melnikova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silencing cAMP-response Element-binding Protein (CREB) IdentifiesCYR61as a Tumor Suppressor Gene in Melanoma

(2009) Andrey S. Dobroff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Final Version of 2009 AJCC Melanoma Staging and Classification

(2009) Charles M. Balch et al.   JOURNAL OF CLINICAL ONCOLOGY

Skin Melanoma Development in ret Transgenic Mice Despite the Depletion of CD25+Foxp3+ Regulatory T Cells in Lymphoid Organs

(2009) S. Kimpfler et al.   JOURNAL OF IMMUNOLOGY

Inflammation and melanoma metastasis

(2009) Vladislava O. Melnikova et al.   Pigment Cell & Melanoma Research

MEK1 mutations confer resistance to MEK and B-RAF inhibition

(2009) C. M. Emery et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Expression Profiling of Galectin-3-Depleted Melanoma Cells Reveals its Major Role in Melanoma Cell Plasticity and Vasculogenic Mimicry

(2008) Alexandra A. Mourad-Zeidan et al.   AMERICAN JOURNAL OF PATHOLOGY

B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells

(2008) T. Azuma et al.   BLOOD

Inefficient presentation of tumor-derived antigen by tumor-infiltrating dendritic cells

(2008) Patrizia Stoitzner et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Attenuation of Melanoma Invasion by a Secreted Variant of Activated Leukocyte Cell Adhesion Molecule

(2008) J. W.J. van Kilsdonk et al.   CANCER RESEARCH

Targeting Melanoma Growth and Metastasis with Systemic Delivery of Liposome-Incorporated Protease-Activated Receptor-1 Small Interfering RNA

(2008) Gabriel J. Villares et al.   CANCER RESEARCH

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy

(2008) Rafael Carretero et al.   IMMUNOGENETICS

Next Generation of Immunotherapy for Melanoma

(2008) John M. Kirkwood et al.   JOURNAL OF CLINICAL ONCOLOGY

CTLA-4 Is a Direct Target of Wnt/β-Catenin Signaling and Is Expressed in Human Melanoma Tumors

(2008) Kavita V. Shah et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Efficient tumour formation by single human melanoma cells

(2008) Elsa Quintana et al.   NATURE

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE

Activated leukocyte cell adhesion molecule: a new paradox in cancer

(2007) Solomon F. Ofori-Acquah et al.   Translational Research