Article
Neurosciences
Wei Xu, Yuman He, Jiamei Zhang, Hongchun Li, Xuemei Wan, Menglu Li, Yonghai Wang, Rui Xu, Haoluo Zhang, Yanping Dai, Haxiaoyu Liu, Linhong Jiang, Ying Zhao, Xiaobo Cen
Summary: The study demonstrates that simvastatin can prevent the reinstatement of cocaine-induced conditioned place preference without affecting its acquisition, likely due to its administration during extinction phase. Lipidomic analysis reveals that the nucleus accumbens is the most affected brain region by simvastatin, with alterations in fatty acids, phospholipids, and triacylglycerol metabolism. Simvastatin reverses most effects on phospholipids induced by cocaine and reshapes lipid metabolic pathways in specific brain regions, ultimately facilitating cocaine extinction and preventing relapse.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Darrell Eacret, Crystal Lemchi, Jasmine I. Caulfield, Sonia A. Cavigelli, Sigrid C. Veasey, Julie A. Blendy
Summary: This study investigates the influence of chronic short sleep on opioid reward using a mouse model. The results show that recovery sleep after chronic sleep disruption lessens voluntary opioid intake, but does not affect conditioned reward associated with morphine.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Psychology, Biological
Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-ih, Ekkasit Kumarnsit
Summary: This study aimed to investigate the neural adaptive mechanisms associated with the formation of morphine conditioned place preference. The findings suggested that NAc LFP signaling and neural connectivities between the NAc and HC may play a role in morphine CPP.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Laila Asth, Lia P. Iglesias, Rayssa C. Brianis, Anna P. Marcal, Nicia P. Soares, Daniele C. Aguiar, Fabricio A. Moreira
Summary: This study examined the effects of monoamine stabilizers and aripiprazole on cocaine-induced behaviors. The results showed that aripiprazole could prevent cocaine-induced hyperlocomotion, but also impaired spontaneous locomotion, while (-)-OSU6162 had a minor effect. (-)-OSU6162 also played a role in preventing the acquisition of cocaine-induced conditioned place preference.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Plant Sciences
Guiyun Wu, Xiaoying Xu, Fang Ye, Haihua Shu
Summary: The study found that processed Aconiti tuber (PAT) shortens the extinction of morphine-induced CPP when administered before CPP formation, but extends the extinction when administered after CPP acquisition. PAT has no effect on the reinstatement of CPP. The dynorphin concentration in the nucleus accumbens increases with PAT administration.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Prableen K. Singh, Kabirullah Lutfy
Summary: The study found differences in cocaine-induced conditioned place preference (CPP) between male and female mice lacking beta-endorphin, with gender-related distinctions in CPP reinstatement. The results suggest a functional role for beta-endorphin in cocaine-induced CPP and reinstatement.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Jing Zhu, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: In this study, a simple and effective experimental model was designed to investigate the generalization memory of morphine reward. By replacing the conditioning CPP box, it was found that mice still showed a clear preference for generalized information. The establishment of this study provides a new tool for studying generalization memory in substance use disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Neurosciences
Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Gao
Summary: Studies have shown that protein phosphorylation is important in morphine abuse, but the role of protein phosphatase 2A (PP2A) in the morphine-priming process is unclear. In this study, conditional knockout mice were used to investigate the role of hippocampal PP2A in morphine priming. The results suggest that hippocampal PP2A may be involved in morphine priming through the PP2A/HDAC4/Rack1 pathway.
Article
Pharmacology & Pharmacy
Gabrielle M. Henriques, Alexia Anjos-Santos, Isa R. S. Rodrigues, Victor Nascimento-Rocha, Henrique S. Reis, Matheus Libarino-Santos, Thaisa Barros-Santos, Thais S. Yokoyama, Natalia B. Bertagna, Cristiane A. Favoretto, Celia R. G. Moraes, Fabio C. Cruz, Paulo C. R. Barbosa, Eduardo A. Marinho, Alexandre J. Oliveira-Lima, Lais F. Berro
Summary: Ibogaine may have therapeutic properties for the treatment of alcohol use disorder without having rewarding effects per se. The study results show that ibogaine can block the reinstatement of ethanol-induced CPP, suggesting its potential as a treatment option for alcohol use disorder.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Zhi-yuan Wang, Liang-kun Guo, Xiao Han, Rui Song, Guo-ming Dong, Chun-ming Ma, Ning Wu, Jin Li
Summary: The study investigated the effects of naltrexone on the properties of incentive salience and reward-related memory in methamphetamine addiction using mouse models. Naltrexone was found to reduce methamphetamine-induced hyper locomotion and suppress the development of locomotor sensitization, suggesting its therapeutic potential in treating methamphetamine addiction. These findings demonstrate that naltrexone could intervene in the incentive salience and reward-related memory properties, contributing to its therapeutic effects on methamphetamine addicts in clinical studies.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
Saurabh S. Kokane, Brandon D. Butler, Josimar Hernandez Antonio, Ross J. Armant, Adam C. Hoch, Clinton S. Coelho, Blake N. Brady, Houda H. Chamseddine, Linda I. Perrotti
Summary: Women show a faster progression, increased consumption, more positive subjective effects, and higher relapse rates during abstinence in cocaine addiction. Estradiol is a key mediator of these effects, and ERK1/2 and mTOR play a role in the underlying neurobiological mechanisms.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Changliang Zhu, Lei Wang, Jiangwei Ding, Hailiang Li, Din Wan, Yangyang Sun, Baorui Guo, Zhenquan He, Xiaofan Ren, Shucai Jiang, Caibing Gao, Hua Guo, Tao Sun, Feng Wang
Summary: This study investigates the potential effects of GLP-1R agonist Ex4 on cocaine relapse behaviors and finds that Ex4 can attenuate cocaine- and stress-induced reinstatement of conditioned place preference (CPP). Furthermore, Ex4 normalizes the expression of NF-kappa beta, which is upregulated by cocaine. These findings suggest that GLP-1R agonists have promising potential in the treatment of cocaine use disorder.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Francisco Rodenas-Gonzalez, Maria Carmen Arenas, Maria Carmen Blanco-Gandia, Carmen Manzanedo, Marta Rodriguez-Arias
Summary: Stress plays a critical role in mood and drug use disorders. A robust female model of social stress needs to be developed. This study focuses on the long-lasting effects of vicarious social defeat (VSD) on cocaine and ethanol intake in female mice. The results show that VSD induces an increase in corticosterone levels, anxiety-like behaviors, and a preference for cocaine and ethanol in female mice.
Article
Neurosciences
Wanyu Tu, Tengteng Zhang, Chenchen Li, Wenge Jia, Zhijun Yao, Shanyong Yi, Hongyun Chen, Yuan Liu, Danya Zhou, Chuansheng Wang, Ruiling Zhang, Zhe Shi, Tifei Yuan, Bin Zhao, Lai Wei
Summary: This study investigated the role of alpha 1 adrenoceptor in the ventrolateral orbital cortex of rats with repeated morphine treatment and its underlying molecular mechanisms. The results showed that prazosin enhanced the addictive effects of morphine and affected neurotransmitter NE and peripheral inflammatory factors. These findings suggest that the NE system may be a potential therapeutic target in morphine addiction.
Article
Pharmacology & Pharmacy
Ellen R. Cullity, Alexandre A. Guerin, Christina J. Perry, Jee Hyun Kim
Summary: Adolescents may be more sensitive to the rewarding effects of methamphetamine, while females may be less likely to form an aversion compared to males. These results are in line with sex-specific findings in human research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
M. P. Garcia-Pardo, J. Minarro, M. A. Aguilar
BEHAVIOURAL BRAIN RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Carmen Ferrer-Perez, Marina D. Reguilon, Carmen Manzanedo, M. Asuncion Aguilar, Jose Minarro, Marta Rodriguez-Arias
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Psychology, Biological
M. Carmen Blanco-Gandia, Sandra Montagud-Romero, Maria A. Aguilar, Jose Minarro, Marta Rodriguez-Arias
PHYSIOLOGY & BEHAVIOR
(2018)
Article
Multidisciplinary Sciences
M. Carmen Blanco-Gandia, Jose Minarro, Maria Asuncion Aguilar, Marta Rodriguez-Arias
Article
Neurosciences
M. C. Arenas, C. I. Navarro-Frances, S. Montagud-Romero, J. Minarro, C. Manzanedo
PSYCHOPHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
M. Carmen Blanco-Gandia, Maria A. Aguilar, Jose Minarro, Marta Rodriguez-Arias
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2018)
Review
Neurosciences
Sandra Montagud-Romero, Maria Carmen Blanco-Gandia, Marina D. Reguilon, Carmen Ferrer-Perez, Raul Ballestin, Jose Minarro, Marta Rodriguez-Arias
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
Marta Rodriguez-Arias, Sandra Montagud-Romero, Ana Maria Guardia Carrion, Carmen Ferrer-Perez, Ana Perez-Villalba, Eva Marco, Meritxell Lopez Gallardo, Maria-Paz Viveros, Jose Minarro
Article
Neurosciences
M. P. Garcia-Pardo, J. Minarro, M. Llansola, V Felipo, M. A. Aguilar
EUROPEAN JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Carmen Ferrer-Perez, Adriana Castro-Zavala, Miguel Angel Lujan, Joanna Filarowska, Raul Ballestin, Jose Minarro, Olga Valverde, Marta Rodriguez-Arias
Article
Behavioral Sciences
M. P. Garcia-Pardo, C. Calpe-Lopez, J. Minarro, M. A. Aguilar
BEHAVIOURAL BRAIN RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Claudia Calpe-Lopez, M. Pilar Garcia-Pardo, Maria A. Aguilar
Article
Clinical Neurology
Claudia Calpe-Lopez, Ani Gasparyan, Francisco Navarrete, Jorge Manzanares, Jose Minarro, Maria A. Aguilar
Summary: The study found that CBD may reduce reinstatement of seeking cocaine in mice, and CBD itself does not induce reinstatement but can block the reinstating effects of cocaine priming and social defeat. Furthermore, cocaine priming increased the gene expression of DAT in the ventral tegmental area, which was completely reversed by CBD.
JOURNAL OF PSYCHOPHARMACOLOGY
(2021)
Article
Psychology, Biological
C. Calpe-Lopez, M. A. Martinez-Caballero, M. P. Garcia-Pardo, M. A. Aguilar
Summary: Promoting resilience to stress through physical exercise can help prevent substance use disorders.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)