Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis

YAP/TAZ Incorporation in the β-Catenin Destruction Complex Orchestrates the Wnt Response

(2014) Luca Azzolin et al.   CELL

Inactivation of Wnt signaling by a human antibody that recognizes the heparan sulfate chains of glypican-3 for liver cancer therapy

(2014) Wei Gao et al.   HEPATOLOGY

Glypican-3 binds to Frizzled and plays a direct role in the stimulation of canonical Wnt signaling

(2014) M. Capurro et al.   JOURNAL OF CELL SCIENCE

Recombinant immunotoxin for cancer treatment with low immunogenicity by identification and silencing of human T-cell epitopes

(2014) R. Mazor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Immunocytokine IL12-SS1 (Fv) Inhibits Mesothelioma Tumor Growth in Nude Mice

(2013) Heungnam Kim et al.   PLoS One

Therapeutically targeting glypican-3 via a conformation-specific single-domain antibody in hepatocellular carcinoma

(2013) M. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Major Cancer Regressions in Mesothelioma After Treatment with an Anti-Mesothelin Immunotoxin and Immune Suppression

(2013) R. Hassan et al.   Science Translational Medicine

TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types

(2012) Amit Chaudhary et al.   CANCER CELL

Efficacy of irinotecan single drug treatment in children with refractory or recurrent hepatoblastoma – A phase II trial of the childhood liver tumour strategy group (SIOPEL)

(2012) József Zsíros et al.   EUROPEAN JOURNAL OF CANCER

Simultaneous inhibition of Src and Aurora kinases by SU6656 induces therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo

(2012) Ryuta Arai et al.   EUROPEAN JOURNAL OF CANCER

Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update

(2012) Angela Gauthier et al.   HEPATOLOGY RESEARCH

Wnt/β-Catenin Signaling Regulates Yes-associated Protein (YAP) Gene Expression in Colorectal Carcinoma Cells

(2012) Wesley M. Konsavage et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

High-affinity monoclonal antibodies to cell surface tumor antigen glypican-3 generated through a combination of peptide immunization and flow cytometry screening

(2012) Yen Phung et al.   mAbs

Advances in Liver Cancer Antibody Therapies

(2011) Mitchell Ho   BIODRUGS

Antibody Fusion Proteins: Anti-CD22 Recombinant Immunotoxin Moxetumomab Pasudotox

(2011) R. J. Kreitman et al.   CLINICAL CANCER RESEARCH

Activation of Phosphatidylinositol 3-Kinase/Akt Signaling Pathway Mediates Acquired Resistance to Sorafenib in Hepatocellular Carcinoma Cells

(2011) K.-F. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment

(2010) E. Van Cutsem et al.   ANNALS OF ONCOLOGY

Glypican-3: A new target for cancer immunotherapy

(2010) Mitchell Ho et al.   EUROPEAN JOURNAL OF CANCER

A novel high-affinity human monoclonal antibody to mesothelin

(2010) Mitchell Ho et al.   INTERNATIONAL JOURNAL OF CANCER

Recombinant soluble glypican 3 protein inhibits the growth of hepatocellular carcinoma in vitro

(2010) Mingqian Feng et al.   INTERNATIONAL JOURNAL OF CANCER

Enhancing the Antitumor Activity of Adriamycin and Ionizing Radiation

(2009) W. Sun et al.   CANCER RESEARCH

Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma

(2009) Hirofumi Shirakawa et al.   CANCER SCIENCE

Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells

(2008) Kiyotaka Nakano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Anti-Glypican 3 Antibody as a Potential Antitumor Agent for Human Liver Cancer

(2008) T. Ishiguro et al.   CANCER RESEARCH

Differential Cellular Internalization of Anti-CD19 and -CD22 Immunotoxins Results in Different Cytotoxic Activity

(2008) X. Du et al.   CANCER RESEARCH

ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for subcutaneous hepatocellular carcinoma xenograft

(2008) Viraj J. Jasinghe et al.   JOURNAL OF HEPATOLOGY

Construction of a Large Phage-Displayed Human Antibody Domain Library with a Scaffold Based On a Newly Identified Highly Soluble, Stable Heavy Chain Variable Domain

(2008) Weizao Chen et al.   JOURNAL OF MOLECULAR BIOLOGY