Renin inhibition in the treatment of diabetic kidney disease: Figure 1

(Pro)renin and its receptors: pathophysiological implications

(2012) Wendy W. Batenburg et al.   CLINICAL SCIENCE

Angiotensin-(1–7) in kidney disease: a review of the controversies

(2012) Danielle Zimmerman et al.   CLINICAL SCIENCE

Identification of the vitamin D receptor in various cells of the mouse kidney

(2012) Yongji Wang et al.   KIDNEY INTERNATIONAL

Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat

(2012) Adam Whaley-Connell et al.   REGULATORY PEPTIDES

Aliskiren vs. Angiotensin Receptor Blockers in Hypertension: Meta-Analysis of Randomized Controlled Trials

(2011) D. Gao et al.   AMERICAN JOURNAL OF HYPERTENSION

Discovery of a potent and selective small molecule hGPR91 antagonist

(2011) Debnath Bhuniya et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Renal (pro)renin receptor contributes to development of diabetic kidney disease through transforming growth factor-β1 - connective tissue growth factor signalling cascade

(2011) Jiqian Huang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Aliskiren in Combination with Losartan Reduces Albuminuria Independent of Baseline Blood Pressure in Patients with Type 2 Diabetes and Nephropathy

(2011) F. Persson et al.   Clinical Journal of the American Society of Nephrology

Effect of the direct renin inhibitor aliskiren on left ventricular remodelling following myocardial infarction with systolic dysfunction

(2011) Scott D. Solomon et al.   EUROPEAN HEART JOURNAL

Associations of albuminuria in patients with chronic heart failure: findings in the ALiskiren Observation of heart Failure Treatment study

(2011) Colette E. Jackson et al.   EUROPEAN JOURNAL OF HEART FAILURE

Prolonged Urocortin 2 Administration in Experimental Heart Failure

(2011) Miriam T. Rademaker et al.   HYPERTENSION

Prorenin Receptor Is Essential for Normal Podocyte Structure and Function

(2011) Y. Oshima et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Podocyte COX-2 Exacerbates Diabetic Nephropathy by Increasing Podocyte (Pro)renin Receptor Expression

(2011) H. Cheng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prorenin Receptor Is Essential for Podocyte Autophagy and Survival

(2011) F. Riediger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Oral cholecalciferol decreases albuminuria and urinary TGF-β1 in patients with type 2 diabetic nephropathy on established renin–angiotensin–aldosterone system inhibition

(2011) Min Jeong Kim et al.   KIDNEY INTERNATIONAL

Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies

(2011) Patricia McGettigan et al.   PLOS MEDICINE

Renal Protective Effects of Aliskiren Beyond Its Antihypertensive Property in a Mouse Model of Progressive Fibrosis

(2010) O. Gross et al.   AMERICAN JOURNAL OF HYPERTENSION

Effect of long-term treatment with urocortin on the activity of somatic angiotensin-converting enzyme in spontaneously hypertensive rats

(2010) Cui Yang et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H + -ATPase Assembly in Murine Cardiomyocytes

(2010) Kenichiro Kinouchi et al.   CIRCULATION RESEARCH

Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system

(2010) Andreas Tomaschitz et al.   CLINICA CHIMICA ACTA

Impact of Baseline Renal Function on the Efficacy and Safety of Aliskiren Added to Losartan in Patients With Type 2 Diabetes and Nephropathy

(2010) F. Persson et al.   DIABETES CARE

Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans

(2010) John P. Forman et al.   HYPERTENSION

Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension

(2010) Masaki Ryuzaki et al.   HYPERTENSION RESEARCH

Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes

(2010) Dilip K. Deb et al.   KIDNEY INTERNATIONAL

Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL study): a randomised controlled trial

(2010) Dick de Zeeuw et al.   LANCET

Requirement of Prorenin Receptor and Vacuolar H+-ATPase-Mediated Acidification for Wnt Signaling

(2010) C.-M. Cruciat et al.   SCIENCE

Urocortin 1 improves renal function in rats with streptozotocin-induced diabetes by inhibiting overproduction of TGF-β1 and VEGF

(2009) Xuan Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

(Pro)renin Receptor-Mediated Signal Transduction and Tissue Renin-Angiotensin System Contribute to Diabetes-Induced Retinal Inflammation

(2009) S. Satofuka et al.   DIABETES

Renal Effects of Aliskiren Compared With and in Combination With Irbesartan in Patients With Type 2 Diabetes, Hypertension, and Albuminuria

(2009) F. Persson et al.   DIABETES CARE

Inhibition of renin/prorenin receptor attenuated mesangial cell proliferation and reduced associated fibrotic factor release

(2009) Ming He et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Chronic Increases in Circulating Prorenin Are not Associated With Renal or Cardiac Pathologies

(2009) Chantal Mercure et al.   HYPERTENSION

The (Pro)Renin Receptor

(2009) Andrew Advani et al.   HYPERTENSION

N -Acetyl-Seryl-Aspartyl-Lysyl-Proline Attenuates Renal Injury and Dysfunction in Hypertensive Rats With Reduced Renal Mass

(2009) Tang-Dong Liao et al.   HYPERTENSION

Dose-dependent titration of prorenin and blood pressure in Cyp1a1ren-2 transgenic rats: absence of prorenin-induced glomerulosclerosis

(2009) Barbara Peters et al.   JOURNAL OF HYPERTENSION

Cost-Effectiveness of Aliskiren in Type 2 Diabetes, Hypertension, and Albuminuria

(2009) T. E. Delea et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of the Succinate Receptor GPR91 in Macula Densa Cells Causes Renin Release

(2009) S. L. Vargas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design

(2009) H.-H. Parving et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Oral Calcitriol for the Treatment of Persistent Proteinuria in Immunoglobulin A Nephropathy: An Uncontrolled Trial

(2008) Cheuk-Chun Szeto et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Urocortin ameliorates diabetic nephropathy in obesedb/dbmice

(2008) X Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Urocortin 2 combined with angiotensin-converting enzyme inhibition in experimental heart failure

(2008) Miriam T. Rademaker et al.   CLINICAL SCIENCE

Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels

(2008) J. A. Sugden et al.   DIABETIC MEDICINE

Prorenin and (pro)renin receptor: a review of available data fromin vitrostudies and experimental models in rodents

(2008) Geneviève Nguyen et al.   EXPERIMENTAL PHYSIOLOGY

Prorenin and Renin-Induced Extracellular Signal-Regulated Kinase 1/2 Activation in Monocytes Is Not Blocked by Aliskiren or the Handle-Region Peptide

(2008) Sandra Feldt et al.   HYPERTENSION

(Pro)Renin Receptor Peptide Inhibitor “Handle-Region” Peptide Does Not Affect Hypertensive Nephrosclerosis in Goldblatt Rats

(2008) Dominik N. Muller et al.   HYPERTENSION

Paricalcitol Reduces Albuminuria and Inflammation in Chronic Kidney Disease

(2008) Pooneh Alborzi et al.   HYPERTENSION

Effects of Aliskiren on Blood Pressure, Albuminuria, and (Pro)Renin Receptor Expression in Diabetic TG(mRen-2)27 Rats

(2008) David L. Feldman et al.   HYPERTENSION

Involvement of receptor-bound prorenin in development of nephropathy in diabetic db/db mice

(2008) Atsuhiro Ichihara et al.   Journal of the American Society of Hypertension

The Putative (Pro)renin Receptor Blocker HRP Fails to Prevent (Pro)renin Signaling

(2008) S. Feldt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium

(2008) Juan Kong et al.   KIDNEY INTERNATIONAL

Suppression of renin–angiotensin gene expression in the kidney by paricalcitol

(2008) Michael Freundlich et al.   KIDNEY INTERNATIONAL

Effect of (pro)renin receptor inhibition by a decoy peptide on renal damage in the clipped kidney of Goldblatt rats

(2008) Christian Krebs et al.   KIDNEY INTERNATIONAL

Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes

(2008) F. Persson et al.   KIDNEY INTERNATIONAL

Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1α-hydroxylase knockout mice

(2008) Chunlei Zhou et al.   KIDNEY INTERNATIONAL

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

(2008) Przemyslaw Sapieha et al.   NATURE MEDICINE

Aliskiren Combined with Losartan in Type 2 Diabetes and Nephropathy

(2008) Hans-Henrik Parving et al.   NEW ENGLAND JOURNAL OF MEDICINE

Combination therapy with AT1 blocker and vitamin D analog markedly ameliorates diabetic nephropathy: Blockade of compensatory renin increase

(2008) Z. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antihypertensive therapy with aliskiren

(2007) F.C. Luft et al.   KIDNEY INTERNATIONAL