Spliceostatin hemiketal biosynthesis in Burkholderia spp. is catalyzed by an iron/ -ketoglutarate-dependent dioxygenase

Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis

(2014) Hai-Yan He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pre-mRNA Splicing-Modulatory Pharmacophores: The Total Synthesis of Herboxidiene, a Pladienolide–Herboxidiene Hybrid Analog and Related Derivatives

(2013) Chandraiah Lagisetti et al.   ACS Chemical Biology

An Enzymatic Domain for the Formation of Cyclic Ethers in Complex Polyketides

(2013) Petra Pöplau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Phase I Pharmacokinetic and Pharmacodynamic Study of the First-in-Class Spliceosome Inhibitor E7107 in Patients with Advanced Solid Tumors

(2013) F. A. L. M. Eskens et al.   CLINICAL CANCER RESEARCH

Isolation and characterization of spliceostatin B, a new analogue of FR901464, from Pseudomonas sp. No. 2663

(2013) Xiangyang Liu et al.   JOURNAL OF ANTIBIOTICS

Coherence between Cellular Responses andin VitroSplicing Inhibition for the Anti-tumor Drug Pladienolide B and Its Analogs

(2013) Kerstin A. Effenberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stabilized Cyclopropane Analogs of the Splicing Inhibitor FD-895

(2013) Reymundo Villa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Remediating Cancer via Splicing Modulation

(2013) Mark S. Butler   JOURNAL OF MEDICINAL CHEMISTRY

Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

(2013) Xiangyang Liu et al.   JOURNAL OF NATURAL PRODUCTS

Enantioselective Syntheses of FR901464 and Spliceostatin A: Potent Inhibitors of Spliceosome

(2013) Arun K. Ghosh et al.   ORGANIC LETTERS

Enantioselective Synthesis of Pladienolide B and Truncated Analogues as New Anticancer Agents

(2013) Vemula Praveen Kumar et al.   ORGANIC LETTERS

Baeyer–Villiger Oxidation of Acyl Carrier Protein-Tethered Thioester to Acyl Carrier Protein-Linked Thiocarbonate Catalyzed by a Monooxygenase Domain in FR901464 Biosynthesis

(2013) Man-Cheng Tang et al.   ACS Catalysis

Substrate Specificity in Ketosynthase Domains fromtrans-AT Polyketide Synthases

(2012) Matthew Jenner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of the Herboxidiene Biosynthetic Gene Cluster in Streptomyces chromofuscus ATCC 49982

(2012) Lei Shao et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Splicing in oncogenesis and tumor suppression

(2012) Daisuke Kaida et al.   CANCER SCIENCE

Baeyer–Villiger C–C Bond Cleavage Reaction in Gilvocarcin and Jadomycin Biosynthesis

(2012) Nidhi Tibrewal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Flavoenzymes: Versatile catalysts in biosynthetic pathways

(2012) Christopher T. Walsh et al.   NATURAL PRODUCT REPORTS

The spliceosome as a target of novel antitumour drugs

(2012) Sophie Bonnal et al.   NATURE REVIEWS DRUG DISCOVERY

Genome Mining inStreptomyces. Elucidation of the Role of Baeyer−Villiger Monooxygenases and Non-Heme Iron-Dependent Dehydrogenase/Oxygenases in the Final Steps of the Biosynthesis of Pentalenolactone and Neopentalenolactone

(2011) Myung-Ji Seo et al.   BIOCHEMISTRY

Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units

(2011) Feng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product

(2010) Makoto Hasegawa et al.   ACS Chemical Biology

Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891: Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation

(2010) Fumitaka Kudo et al.   CHEMBIOCHEM

Biosynthesis of polyketides by trans-AT polyketide synthases

(2010) Jörn Piel   NATURAL PRODUCT REPORTS

Revisiting the modularity of modular polyketide synthases

(2009) Chaitan Khosla et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

PKS and NRPS release mechanisms

(2009) Liangcheng Du et al.   NATURAL PRODUCT REPORTS

Organization of the Biosynthetic Gene Cluster for the Polyketide Antitumor Macrolide, Pladienolide, inStreptomyces platensisMer-11107

(2008) Kazuhiro MACHIDA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Recovery of a Burkholderia thailandensis-like isolate from an Australian water source

(2008) Jay E Gee et al.   BMC MICROBIOLOGY

Functional Analysis of MycCI and MycG, Cytochrome P450 Enzymes Involved in Biosynthesis of Mycinamicin Macrolide Antibiotics

(2008) Yojiro Anzai et al.   CHEMISTRY & BIOLOGY