Regulated ADAM17-dependent EGF family ligand release by substrate-selecting signaling pathways

Systemic Overexpression of TNFα-converting Enzyme Does Not Lead to Enhanced Shedding Activity In Vivo

(2013) Masaki Yoda et al.   PLoS One

Monoubiquitination of pro-amphiregulin regulates its endocytosis and ectodomain shedding

(2012) Shinji Fukuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Discovery of Novel Inhibitors of a Disintegrin and Metalloprotease 17 (ADAM17) Using Glycosylated and Non-glycosylated Substrates

(2012) Dmitriy Minond et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interleukin-1 Stimulates ADAM17 through a Mechanism Independent of its Cytoplasmic Domain or Phosphorylation at Threonine 735

(2012) Katherine C. Hall et al.   PLoS One

TACE Activation by MAPK-Mediated Regulation of Cell Surface Dimerization and TIMP3 Association

(2012) P. Xu et al.   Science Signaling

Neuregulin1 as Novel Therapy for Heart Failure

(2011) Xinhua Yan et al.   CURRENT PHARMACEUTICAL DESIGN

Ectodomain shedding and remnant peptide signalling of EGFRs and their ligands

(2011) S. Higashiyama et al.   JOURNAL OF BIOCHEMISTRY

Epidermal Growth Factor (EGF) Ligand Release by Substrate-specific A Disintegrin and Metalloproteases (ADAMs) Involves Different Protein Kinase C (PKC) Isoenzymes Depending on the Stimulus

(2011) Michelle Dang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PKCα and PKCδ Regulate ADAM17-Mediated Ectodomain Shedding of Heparin Binding-EGF through Separate Pathways

(2011) Marie Kveiborg et al.   PLoS One

The cytoplasmic domains of TNFα-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding

(2010) David J. Killock et al.   BIOCHEMICAL JOURNAL

Thiol isomerases negatively regulate the cellular shedding activity of ADAM17

(2010) Sofie H. Willems et al.   BIOCHEMICAL JOURNAL

The “A Disintegrin And Metalloproteases” ADAM10 and ADAM17: Novel drug targets with therapeutic potential?

(2010) Paul Saftig et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Proteolytic Activity Matrix Analysis (PrAMA) for simultaneous determination of multiple protease activities

(2010) Miles A. Miller et al.   Integrative Biology

ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site

(2010) S. M. Le Gall et al.   JOURNAL OF CELL SCIENCE

Active Metalloproteases of the A Disintegrin And Metalloprotease (ADAM) Family: Biological Function and Structure

(2010) Theo Klein et al.   JOURNAL OF PROTEOME RESEARCH

TGF-  Mediates Genetic Susceptibility to Chronic Kidney Disease

(2010) D. Laouari et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Direct Activation of TACE-Mediated Ectodomain Shedding by p38 MAP Kinase Regulates EGF Receptor-Dependent Cell Proliferation

(2010) Pinglong Xu et al.   MOLECULAR CELL

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of Cellular Protein Phosphatase-1 (PP1) by Phosphorylation of the CPI-17 Family, C-kinase-activated PP1 Inhibitors

(2009) Masumi Eto   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurotrophins Induce Neuregulin Release through Protein Kinase Cδ Activation

(2009) Raymond M. Esper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

(2009) Sylvain M. Le Gall et al.   MOLECULAR BIOLOGY OF THE CELL

ADAM-17 predicts adverse outcome in patients with breast cancer

(2008) P. M. McGowan et al.   ANNALS OF ONCOLOGY

The role of protease activity in ErbB biology

(2008) Carl P. Blobel et al.   EXPERIMENTAL CELL RESEARCH

Ectodomain cleavage of the EGF ligands HB-EGF, neuregulin1-β, and TGF-α is specifically triggered by different stimuli and involves different PKC isoenzymes

(2008) Andreas Herrlich et al.   FASEB JOURNAL

The epidermal growth factor receptor ligands at a glance

(2008) Marlon R. Schneider et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Amphiregulin: Role in Mammary Gland Development and Breast Cancer

(2008) Jean McBryan et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Regulation of the proteolytic disintegrin metalloproteinases, the ‘Sheddases’

(2008) Gillian Murphy   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY