Article
Medicine, Research & Experimental
Gefei Wu, Jiasheng Hu, Hongmin Zhu, Shuhua Wu, Sheng Huang, Zhisheng Liu
Summary: The study demonstrated the therapeutic effect of melatonin (MT) on febrile convulsion (FC) by modulating the MEG3/miR-223/PTEN/AKT pathway, suggesting MT as a novel strategy for FC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Clinical Neurology
Jiaxu Wang, Meng Li, Jing Zhang, Qing Gao, Zhaoxi Ding, Jinhao Sun
Summary: The aim of this animal study was to investigate the mechanisms underlying the efficacy of paliperidone, an antipsychotic drug approved by the US FDA for the treatment of schizophrenia. The results showed that paliperidone alleviated neuronal damage induced by MK-801 through the PP2A/PTEN pathway.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Medicine, Research & Experimental
Colin Carlock, Yunpeng Bai, Allison Paige-Hood, Qinglin Li, Frederick Nguele Meke, Zhong-Yin Zhang
Summary: Overexpression of PRL2 and reduced PTEN protein are frequently observed in patients with acute myeloid leukemia (AML). Inhibiting PRL2 can prolong animal survival and slow the accumulation of leukemia blasts in the bone marrow niche. This study provides evidence for the viability of PRL2 inhibition as a therapeutic strategy for improving clinical outcomes in AML and other PTEN-deficient cancers.
Article
Cell Biology
Wenwen Liu, Lei Xu, Xue Wang, Daogong Zhang, Gaoying Sun, Man Wang, Mingming Wang, Yuechen Han, Renjie Chai, Haibo Wang
Summary: Activated autophagic flux in SGNs after cisplatin treatment can alleviate SGN apoptosis and related hearing loss, indicating a neuroprotective role of autophagy. The antioxidant enzyme PRDX1 plays a crucial role in modulating autophagy in SGNs, which in turn activates the PTEN-AKT signaling pathway to trigger autophagy. These findings suggest potential therapeutic targets for drug-induced SNHL through autophagy activation.
Article
Biochemistry & Molecular Biology
Haochen Guan, Nan Zhu, Gang Tang, Yi Du, Ling Wang, Weijie Yuan
Summary: This study elucidates the potential epigenetic mechanisms underlying HBx-induced renal injuries in HBV-GN and demonstrates the renoprotective effects of inhibiting DNMT1.
CELL AND BIOSCIENCE
(2022)
Article
Engineering, Mechanical
Nan Liu, Hongli Yang, Shasha Li, Danni Wang, Liangui Yang
Summary: The team constructed a coupling model involving p53-Mdm2 negative feedback loop and p53-PTEN-Mdm2 positive feedback loop, finding that PTEN is crucial for p53 oscillation or bistable switching dynamic behaviors, and the positive feedback loop may enrich the dynamic behaviors of the p53 system.
ACTA MECHANICA SINICA
(2021)
Article
Health Care Sciences & Services
Chiao-Yun Lin, Ren-Chin Wu, Lan-Yan Yang, Shih-Ming Jung, Shir-Hwa Ueng, Yun-Hsin Tang, Huei-Jean Huang, Hsiu-Jung Tung, Cheng-Tao Lin, Hsuan-Yu Chen, Angel Chao, Chyong-Huey Lai
Summary: Diagnostic agreement among pathologists for endometrial hyperplasia is poor. This study identified miR-30a-3p, miR-141, miR-200a, miR-200b, and complete PTEN loss as useful tissue biomarkers for predicting endometrial cancer risk in patients with simple or complex hyperplasia without atypia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Jiajia Zhang, Ping Wang, Yanli Cui
Summary: The long noncoding RNA NEAT1 is significantly upregulated in laryngocarcinoma tissues and cells, promoting cell proliferation and invasion by inhibiting miR-524-5p expression. NEAT1 enhances the expression of HDAC1 by sponging miR-524-5p, which in turn affects the PTEN/AKT signaling pathway.
Article
Biochemistry & Molecular Biology
Asish Dasgupta, Kuang-Hueih Chen, Patricia D. A. Lima, Jeffrey Mewburn, Danchen Wu, Ruaa Al-Qazazi, Oliver Jones, Lian Tian, Francois Potus, Sebastien Bonnet, Stephen L. Archer
Summary: The study identified that excessive phosphorylation of Mfn2 leads to proteasomal degradation in PAH and NSCLC, and inhibiting this phosphorylation may hold therapeutic potential for these diseases. By modifying Mfn2 constructs, it was shown that increasing Mfn2 expression can suppress cell proliferation and induce apoptosis in these conditions.
Article
Cell Biology
Huizhen Wang, Yifan Wang, Xin Wang, Huimi Huang, Jingfu Bao, Wenhui Zhong, Aiqing Li
Summary: PTEN plays a crucial role in renal adaptive repair by upregulating CHMP2A to alleviate cell damage, apoptosis, and renal fibrosis. PTEN overexpression promotes phagosome closure, providing a potential therapeutic target for the transition from AKI to CKD.
CELL DEATH & DISEASE
(2021)
Article
Chemistry, Medicinal
Zhongwei Zhang, Caiping Song, Tao Wang, Lei Sun, Ling Qin, Jianghua Ju
Summary: The study found that miR-139-5p promotes retinal neovascularization by suppressing PTEN expression. High glucose treatment increases miR-139-5p levels, leading to enhanced cell migration, tube formation, and VEGF protein levels.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Medicine, General & Internal
Huiying Wan, Dingding Zhang, Weimin Hu, Zhen Xie, Qiu Du, Qiongrong Xia, Taishen Wen, Haiping Jia
Summary: Angiosarcoma is a rare and highly aggressive malignant tumor derived from endothelial cells. This study found significantly lower PTEN expression but higher PIK3CA, pMAPK, and TP53 expression in angiosarcoma compared to benign hemangioma. The presence of apoptosis and correlation with tumor differentiation in angiosarcoma suggest potential therapeutic targets in the PI3K, MAPK, and TP53 pathways.
Article
Oncology
Ming Ye, Hui Wu, Shuguo Li
Summary: Resveratrol exerts neuroprotective effects on primary cortical neurons subjected to oxygen/glucose deprivation/reoxygenation (OGD/R) by modulating mitophagy, improving cell viability, suppressing apoptosis, alleviating loss of mitochondrial membrane potential and excessive oxidative stress. The protective effects are mediated, at least in part, by promoting mitophagy through the PTEN-induced kinase 1/Parkin pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Zhenze Lu, Ling Li, Lei Wei, Jifu Cai, Jun Wu
Summary: This study revealed that LOC366613 plays a crucial role in cerebral I/R injury by regulating the miR-532-5p/PTEN axis, mediating biological functions such as cell apoptosis, cell survival, and LDH release.
Article
Medicine, Research & Experimental
Yonghua Lei, Ming Yang, Hong Li, Rongjuan Xu, Junbao Liu
Summary: The study revealed that miR-130b is downregulated in diabetic encephalopathy, and exerts a protective effect against oxidative stress injury by activating the PI3K/Akt signaling pathway through regulating PTEN.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)