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(2019) Bin Ye et al.   Frontiers in Neuroscience

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(2019) Shelly Fripont et al.   Jove-Journal of Visualized Experiments

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(2019) Bin Ye et al.   Autophagy

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(2019) Shasha Guo et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

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(2019) Erica Gentilin et al.   TRENDS IN MOLECULAR MEDICINE

Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro

(2019) Tianyi Liu et al.   TOXICOLOGY LETTERS

Pou4f3 gene mutation promotes autophagy and apoptosis of cochlear hair cells in cisplatin-induced deafness mice

(2019) Feilong Xu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

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(2018) Wenwen Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

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(2018) Zeynep Soyman et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

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(2018) Yoon Min et al.   Autophagy

PINK1 Protects Auditory Hair Cells and Spiral Ganglion Neurons from Cisplatin-induced Ototoxicity via Inducing Autophagy and Inhibiting JNK Signaling Pathway

(2018) Qianqian Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants

(2018) Maria J. Duarte et al.   MOLECULAR THERAPY

Activation of NLRX1-mediated autophagy accelerates the ototoxic potential of cisplatin in auditory cells

(2018) Haiyan Yin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Protective effect of gallic acid against cisplatin-induced ototoxicity in rats

(2018) Korhan Kilic et al.   Brazilian Journal of Otorhinolaryngology

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy

(2018) Jin-Hwan Kim et al.   CELL DEATH AND DIFFERENTIATION

Tuberous sclerosis complex–mediated mTORC1 overactivation promotes age-related hearing loss

(2018) Xiaolong Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Peroxiredoxin 1/2 protects brain against H2O2-induced apoptosis after subarachnoid hemorrhage

(2018) Yue Lu et al.   FASEB JOURNAL

Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial

(2017) Jonathan Kil et al.   LANCET

Mechanisms of Cisplatin-Induced Ototoxicity and Otoprotection

(2017) Sandeep Sheth et al.   Frontiers in Cellular Neuroscience

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(2017) Chisato Fujimoto et al.   Cell Death & Disease

Epigallocatechin-3-gallate, a prototypic chemopreventative agent for protection against cisplatin-based ototoxicity

(2017) Vikrant Borse et al.   Cell Death & Disease

Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins

(2016) Ivan Verrastro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity

(2016) Samson Jamesdaniel et al.   Redox Biology

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(2016) Jiaojiao Pang et al.   PLoS One

Autophagy Attenuates Noise-Induced Hearing Loss by Reducing Oxidative Stress

(2015) Hu Yuan et al.   ANTIOXIDANTS & REDOX SIGNALING

Age-regulated function of autophagy in the mouse inner ear

(2015) Rocío de Iriarte Rodríguez et al.   HEARING RESEARCH

Sensitivity of spiral ganglion neurons to damage caused by mobile phone electromagnetic radiation will increase in lipopolysaccharide-induced inflammation in vitro model

(2015) Wen-Qi Zuo et al.   Journal of Neuroinflammation

Cisplatin and oxaliplatin are toxic to cochlear outer hair cells and both target thioredoxin reductase in organ of Corti cultures

(2014) Pascal Dammeyer et al.   ACTA OTO-LARYNGOLOGICA

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(2014) Rodrigo Portes Ureshino et al.   ANTIOXIDANTS & REDOX SIGNALING

Rapamycin alleviates cisplatin-induced ototoxicity in vivo

(2014) Bin Fang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prevention of Cisplatin-Induced Hearing Loss by Intratympanic Dexamethasone

(2014) Tal Marshak et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Impaired Autophagy Contributes to Adverse Cardiac Remodeling in Acute Myocardial Infarction

(2014) Xiaoqian Wu et al.   PLoS One

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(2014) G. S. G. Geleoc et al.   SCIENCE

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(2013) Gerard O'Donoghue   NEW ENGLAND JOURNAL OF MEDICINE

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(2013)   NEW ENGLAND JOURNAL OF MEDICINE

Autophagy induction by low-dose cisplatin: The role of p53 in autophagy

(2013) KYUNG-HWA CHO et al.   ONCOLOGY REPORTS

Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development

(2013) Hyung Jin Kim et al.   PLoS One

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(2013) Thorsten Langer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

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(2012) Tetsuro Ishii et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Oxidative Stress, Inflammation, and Autophagic Stress as the Key Mechanisms of Premature Age-Related Hearing Loss in SAMP8 Mouse Cochlea

(2011) Julien Menardo et al.   ANTIOXIDANTS & REDOX SIGNALING

The spiral ganglion: Connecting the peripheral and central auditory systems

(2011) Bryony A. Nayagam et al.   HEARING RESEARCH

In-depth Identification of Pathways Related to Cisplatin-induced Hepatotoxicity through an Integrative Method Based on an Informatics-assisted Label-free Protein Quantitation and Microarray Gene Expression Approach

(2011) Young-Eun Cho et al.   MOLECULAR & CELLULAR PROTEOMICS

Short interfering RNA against STAT1 attenuates cisplatin-induced ototoxicity in the rat by suppressing inflammation

(2011) T Kaur et al.   Cell Death & Disease

Transtympanic Administration of Short Interfering (si)RNA for the NOX3 Isoform of NADPH Oxidase Protects Against Cisplatin-Induced Hearing Loss in the Rat

(2010) Debashree Mukherjea et al.   ANTIOXIDANTS & REDOX SIGNALING

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(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2010) Youyi Dong et al.   NEUROREPORT

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(2009) David C. Rubinsztein et al.   Autophagy

The Antioxidant Enzyme Prdx1 Controls Neuronal Differentiation by Thiol-Redox-Dependent Activation of GDE2

(2009) Ye Yan et al.   CELL

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(2009) Juxiang Cao et al.   EMBO JOURNAL

Ebselen attenuates cisplatin-induced ROS generation through Nrf2 activation in auditory cells

(2009) Se-Jin Kim et al.   HEARING RESEARCH

Peroxiredoxin I plays a protective role against cisplatin cytotoxicity through mitogen activated kinase signals

(2009) Dongmei Ma et al.   ORAL ONCOLOGY

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(2008) Beth Levine et al.   CELL

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(2008) Noboru Mizushima et al.   NATURE