PINK1‐induced phosphorylation of mitofusin 2 at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial hypertension

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

(2020) Yuhu He et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

An epigenetic increase in mitochondrial fission by MiD49 and MiD51 regulates the cell cycle in cancer: Diagnostic and therapeutic implications

(2020) Asish Dasgupta et al.   FASEB JOURNAL

Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: Therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury

(2019) Danchen Wu et al.   FASEB JOURNAL

Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension

(2018) Kuang-Hueih Chen et al.   CIRCULATION

Increased Drp1-Mediated Mitochondrial Fission Promotes Proliferation and Collagen Production by Right Ventricular Fibroblasts in Experimental Pulmonary Arterial Hypertension

(2018) Lian Tian et al.   Frontiers in Physiology

HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer

(2018) Chih-Yang Huang et al.   Cell Death & Disease

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

(2017) Ke Xu et al.   Scientific Reports

CaMKII induces permeability transition through Drp1 phosphorylation during chronic β-AR stimulation

(2016) Shangcheng Xu et al.   Nature Communications

Early ERK1/2 activation promotes DRP1-dependent mitochondrial fission necessary for cell reprogramming

(2016) Javier Prieto et al.   Nature Communications

Downregulation of MicroRNA-126 Contributes to the Failing Right Ventricle in Pulmonary Arterial HypertensionCLINICAL PERSPECTIVE

(2015) François Potus et al.   CIRCULATION

Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells

(2015) Asish Dasgupta et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dynamics in pulmonary arterial hypertension

(2015) John Ryan et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors

(2015) Madhavika N. Serasinghe et al.   MOLECULAR CELL

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

PGC1α-mediated Mitofusin-2 Deficiency in Female Rats and Humans with Pulmonary Arterial Hypertension

(2013) John J. Ryan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Role of mitofusin 2 (Mfn2) in controlling cellular proliferation

(2013) Kuang-Hueih Chen et al.   FASEB JOURNAL

Anti-Tumor Effects of Mfn2 in Gastric Cancer

(2013) Ge-Er Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial Dynamics — Mitochondrial Fission and Fusion in Human Diseases

(2013) Stephen L. Archer   NEW ENGLAND JOURNAL OF MEDICINE

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

(2013) Y. Chen et al.   SCIENCE

Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension

(2012) Glenn Marsboom et al.   CIRCULATION RESEARCH

Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer

(2012) Jalees Rehman et al.   FASEB JOURNAL

Stress-Induced Phosphorylation and Proteasomal Degradation of Mitofusin 2 Facilitates Mitochondrial Fragmentation and Apoptosis

(2012) Guillaume P. Leboucher et al.   MOLECULAR CELL

Protein Kinase A in Cancer

(2011) Antonio Caretta et al.   Cancers

Smad-Dependent and Smad-Independent Induction of Id1 by Prostacyclin Analogues Inhibits Proliferation of Pulmonary Artery Smooth Muscle Cells In Vitro and In Vivo

(2010) Jun Yang et al.   CIRCULATION RESEARCH

Pro-apoptotic and anti-proliferative effects of mitofusin-2 via Bax signaling in hepatocellular carcinoma cells

(2010) Weilin Wang et al.   MEDICAL ONCOLOGY

Chemical Inhibition of the Mitochondrial Division Dynamin Reveals Its Role in Bax/Bak-Dependent Mitochondrial Outer Membrane Permeabilization

(2008) Ann Cassidy-Stone et al.   DEVELOPMENTAL CELL

Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

(2008) G. M. Cereghetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA