Therapeutic Actions of the Thiazolidinediones in Alzheimer’s Disease

Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease

(2018) James L. Searcy et al.   JOURNAL OF ALZHEIMERS DISEASE

Rosiglitazone Improves Learning and Memory Ability in Rats With Type 2 Diabetes Through the Insulin Signaling Pathway

(2015) Lina Ma et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Effect of pioglitazone medication on the incidence of dementia

(2015) Michael T. Heneka et al.   ANNALS OF NEUROLOGY

Advances in Alzheimer’s Disease Drug Development

(2015) Michael S Rafii et al.   BMC Medicine

Current Practices in the Treatment of Alzheimer Disease: Where is the Evidence After the Phase III Trials?

(2015) Megan J. Ehret et al.   CLINICAL THERAPEUTICS

The peroxisome proliferators activated receptor-gamma agonists as therapeutics for the treatment of Alzheimer's disease and mild-to-moderate Alzheimer's disease: a meta-analysis

(2015) Huawei Cheng et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Nuclear Receptors License Phagocytosis by Trem2+ Myeloid Cells in Mouse Models of Alzheimer's Disease

(2015) J. C. Savage et al.   JOURNAL OF NEUROSCIENCE

Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

(2015) Sagar H. Barage et al.   NEUROPEPTIDES

Mitochondrial Dysfunction Contributes to the Pathogenesis of Alzheimer’s Disease

(2015) Fabian A. Cabezas-Opazo et al.   Oxidative Medicine and Cellular Longevity

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

Anti-Diabetes Drug Pioglitazone Ameliorates Synaptic Defects in AD Transgenic Mice by Inhibiting Cyclin-Dependent Kinase5 Activity

(2015) Jinan Chen et al.   PLoS One

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Mitochondrial target of thiazolidinediones

(2014) J. R. Colca et al.   DIABETES OBESITY & METABOLISM

Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice

(2014) Yang Yu et al.   JOURNAL OF NEURAL TRANSMISSION

Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality

(2014) Elias Utreras et al.   Journal of Neuroinflammation

PPAR  Recruitment to Active ERK during Memory Consolidation Is Required for Alzheimer's Disease-Related Cognitive Enhancement

(2014) J. B. Jahrling et al.   JOURNAL OF NEUROSCIENCE

Animal models of dementia and cognitive dysfunction

(2014) Neha et al.   LIFE SCIENCES

Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease

(2014) Augusta Pisanu et al.   NEUROBIOLOGY OF DISEASE

Rosiglitazone prevents the memory deficits induced by amyloid-beta oligomers via inhibition of inflammatory responses

(2014) Shujun Xu et al.   NEUROSCIENCE LETTERS

Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

(2014) Juvenal A. Ríos et al.   PROGRESS IN NEUROBIOLOGY

Cyclin-dependent kinase 5, a node protein in diminished tauopathy: a systems biology approach

(2014) John F. Castro-Alvarez et al.   Frontiers in Aging Neuroscience

Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin-dependent kinase 5 activity in SH-SY5Y neuroblastoma cells and primary neurons

(2013) Du-Hyong Cho et al.   JOURNAL OF NEUROCHEMISTRY

Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway

(2013) Ming-Chang Chiang et al.   MITOCHONDRION

Peroxisome Proliferator-activated Receptors and Alzheimer's Disease: Hitting the Blood–Brain Barrier

(2013) Juan M. Zolezzi et al.   MOLECULAR NEUROBIOLOGY

Role of Nuclear Receptor on Regulation of BDNF and Neuroinflammation in Hippocampus of β-Amyloid Animal Model of Alzheimer’s Disease

(2013) Atish Prakash et al.   NEUROTOXICITY RESEARCH

Pioglitazone Improves Reversal Learning and Exerts Mixed Cerebrovascular Effects in a Mouse Model of Alzheimer’s Disease with Combined Amyloid-β and Cerebrovascular Pathology

(2013) Panayiota Papadopoulos et al.   PLoS One

Identification of 15d-PGJ2 as an antagonist of farnesoid X receptor: Molecular modeling with biological evaluation

(2013) Xing Xu et al.   STEROIDS

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Alzheimer Mechanisms and Therapeutic Strategies

(2012) Yadong Huang et al.   CELL

PPAR /RXR -Induced and CD36-Mediated Microglial Amyloid-  Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice

(2012) M. Yamanaka et al.   JOURNAL OF NEUROSCIENCE

Mechanisms Underlying the Rapid Peroxisome Proliferator-Activated Receptor- -Mediated Amyloid Clearance and Reversal of Cognitive Deficits in a Murine Model of Alzheimer's Disease

(2012) S. Mandrekar-Colucci et al.   JOURNAL OF NEUROSCIENCE

PPARγagonist pioglitazone improves scopolamine-induced memory impairment in mice

(2012) Guo Qing Xiang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Rosiglitazone Improves Spatial Memory and Decreases Insoluble Aβ1–42 in APP/PS1 Mice

(2011) Julie-Ann O’Reilly et al.   Journal of Neuroimmune Pharmacology

The ε3 and ε4 Alleles of Human APOE Differentially Affect Tau Phosphorylation in Hyperinsulinemic and Pioglitazone Treated Mice

(2011) Alvina W. M. To et al.   PLoS One

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Rosiglitazone reduces tau phosphorylation via JNK inhibition in the hippocampus of rats with type 2 diabetes and tau transfected SH-SY5Y cells

(2010) Seung-Yong Yoon et al.   NEUROBIOLOGY OF DISEASE

The Genetics of Alzheimer Disease: Back to the Future

(2010) Lars Bertram et al.   NEURON

Rosiglitazone Rescues Memory Impairment in Alzheimer's Transgenic Mice: Mechanisms Involving a Reduced Amyloid and Tau Pathology

(2010) Luis Escribano et al.   NEUROPSYCHOPHARMACOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury

(2009) Dong-Hyung Cho et al.   SCIENCE