A systematic review of known mechanisms of hydroxyurea-induced fetal hemoglobin for treatment of sickle cell disease

Provider Barriers to Hydroxyurea Use in Adults with Sickle Cell Disease: A Survey of the Sickle Cell Disease Adult Provider Network

(2016) Sophie Lanzkron et al.   JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION

A Systematic Review of Barriers and Interventions to Improve Appropriate Use of Therapies for Sickle Cell Disease

(2016) Carlton Haywood et al.   JOURNAL OF THE NATIONAL MEDICAL ASSOCIATION

Beta-Globin Gene Haplotypes Among Cameroonians and Review of the Global Distribution: Is There a Case for a Single Sickle Mutation Origin in Africa?

(2015) Valentina J. Ngo Bitoungui et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Hydroxyurea-inducible SAR1 gene acts through the Gi /JNK/Jun pathway to regulate  -globin expression

(2014) J. Zhu et al.   BLOOD

Induction of fetal hemoglobin through enhanced translation efficiency of  -globin mRNA

(2014) C. K. Hahn et al.   BLOOD

Reproductive issues in sickle cell disease

(2014) K. Smith-Whitley   BLOOD

The Interaction Between Sickle Cell Disease and HIV Infection: A Systematic Review

(2014) E. D. A. Owusu et al.   CLINICAL INFECTIOUS DISEASES

Endothelium-derived nitric oxide production is increased by ATP released from red blood cells incubated with hydroxyurea

(2014) Sarah Y. Lockwood et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Association of Variants at BCL11A and HBS1L-MYB with Hemoglobin F and Hospitalization Rates among Sickle Cell Patients in Cameroon

(2014) Ambroise Wonkam et al.   PLoS One

Associations between Red Cell Polymorphisms and Plasmodium falciparum Infection in the Middle Belt of Ghana

(2014) Nicholas Amoako et al.   PLoS One

Hydroxyurea therapy contributes to infertility in adult men with sickle cell disease: a review

(2014) Michael R DeBaun   Expert Review of Hematology

Genetic modifiers of sickle cell anemia in the BABY HUG cohort: influence on laboratory and clinical phenotypes

(2013) Vivien A. Sheehan et al.   AMERICAN JOURNAL OF HEMATOLOGY

National Institutes of Health Consensus Development Conference Statement: Hydroxyurea Treatment for Sickle Cell Disease

(2013) Otis W. Brawley   ANNALS OF INTERNAL MEDICINE

Eukaryotic initiation factor 2  phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism

(2013) C. K. Hahn et al.   BLOOD

Fetal hemoglobin in sickle cell anemia: Genetic studies of the Arab-Indian haplotype

(2013) Duyen Ngo et al.   BLOOD CELLS MOLECULES AND DISEASES

The effect of hydroxcarbamide therapy on survival of children with sickle cell disease

(2013) Clarisse Lopes de Castro Lobo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sickle Cell Disease Subphenotypes in Patients From Southwestern Province of Saudi Arabia

(2013) Abdulrahman Alsultan et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Exploring barriers and facilitators to clinical trial enrollment in the context of sickle cell anemia and hydroxyurea

(2013) Jeffrey D. Lebensburger et al.   PEDIATRIC BLOOD & CANCER

An Erythroid Enhancer of BCL11A Subject to Genetic Variation Determines Fetal Hemoglobin Level

(2013) D. E. Bauer et al.   SCIENCE

Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice

(2012) C. B. Almeida et al.   BLOOD

Hydroxycarbamide: Clinical aspects

(2012) Russell E. Ware   COMPTES RENDUS BIOLOGIES

Clinical management of adult sickle-cell disease

(2012) Pablo Bartolucci et al.   CURRENT OPINION IN HEMATOLOGY

Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates

(2012) Frédéric B Piel et al.   LANCET

Parental and other factors associated with hydroxyurea use for pediatric sickle cell disease

(2012) Suzette O. Oyeku et al.   PEDIATRIC BLOOD & CANCER

Hydroxyurea for the treatment of sickle cell disease: Efficacy, barriers, toxicity, and management in children

(2012) John J. Strouse et al.   PEDIATRIC BLOOD & CANCER

Beyond the Definitions of the Phenotypic Complications of Sickle Cell Disease: An Update on Management

(2012) Samir K. Ballas et al.   TheScientificWorldJOURNAL

MODULATING EFFECT OF THE −158 GΓ (C→T) XMN-1 POLYMORPHISM IN INDIAN SICKLE CELL PATIENTS

(2012) Sanjay Pandey et al.   Mediterranean Journal of Hematology and Infectious Diseases

Protective role of hemoglobin and fetal hemoglobin in early kidney disease for children with sickle cell anemia

(2011) Jeffrey Lebensburger et al.   AMERICAN JOURNAL OF HEMATOLOGY

Nitric oxide reduces sickle hemoglobin polymerization: Potential role of nitric oxide-induced charge alteration in depolymerization

(2011) Tohru Ikuta et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia

(2011) R. E. Ware et al.   BLOOD

Epigenetic and molecular profiles of erythroid cells after hydroxyurea treatment in sickle cell anemia

(2011) A. L. Walker et al.   BLOOD

Regulation of γ-globin gene expression involves signaling through the p38 MAPK/CREB1 pathway

(2011) Valya Ramakrishnan et al.   BLOOD CELLS MOLECULES AND DISEASES

Limitations of Hb F as a Phenotypic Modifier in Sickle Cell Disease: Study of Kuwaiti Arab Patients

(2011) Adekunle D. Adekile   HEMOGLOBIN

MicroRNAs: Allies or Foes in erythropoiesis?

(2011) John C.H. Byon et al.   JOURNAL OF CELLULAR PHYSIOLOGY

MicroRNA-148b is frequently down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting cell proliferation

(2011) Yong-Xi Song et al.   Molecular Cancer

A Functional Element Necessary for Fetal Hemoglobin Silencing

(2011) Vijay G. Sankaran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Xmn1-Gγ polymorphism and clinical predictors of severity of disease in β-thalassemia intermedia

(2011) Sapna Oberoi et al.   PEDIATRIC BLOOD & CANCER

Stroke with transfusions changing to hydroxyurea (SWiTCH): A phase III randomized clinical trial for treatment of children with sickle cell anemia, stroke, and iron overload

(2011) Russell E. Ware et al.   PEDIATRIC BLOOD & CANCER

Genetic Etiologies for Phenotypic Diversity in Sickle Cell Anemia

(2011) Martin H. Steinberg   TheScientificWorldJOURNAL

Hydroxyurea in children with sickle cell disease: Practice patterns and barriers to utilization

(2010) Amanda M. Brandow et al.   AMERICAN JOURNAL OF HEMATOLOGY

Genetics of fetal hemoglobin in Tanzanian and British patients with sickle cell anemia

(2010) J. Makani et al.   BLOOD

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease

(2010) C. Sangokoya et al.   BLOOD

Cucurbitacin D induces fetal hemoglobin synthesis in K562 cells and human hematopoietic progenitors through activation of p38 pathway and stabilization of the γ-globin mRNA

(2010) Kan Liu et al.   BLOOD CELLS MOLECULES AND DISEASES

Update on fetal hemoglobin gene regulation in hemoglobinopathies

(2010) Daniel E Bauer et al.   CURRENT OPINION IN PEDIATRICS

Hydroxyurea stimulates the release of ATP from rabbit erythrocytes through an increase in calcium and nitric oxide production

(2010) Madushi Raththagala et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Transcriptional silencing of  -globin by BCL11A involves long-range interactions and cooperation with SOX6

(2010) J. Xu et al.   GENES & DEVELOPMENT

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model

(2010) J. D. Lebensburger et al.   HAEMATOLOGICA

Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia

(2010) Jonathan M. Flanagan et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

(2010) Joseph Borg et al.   NATURE GENETICS

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS)

(2009) E. Voskaridou et al.   BLOOD

cJun modulates Gγ-globin gene expression via an upstream cAMP response element

(2009) Sirisha Kodeboyina et al.   BLOOD CELLS MOLECULES AND DISEASES

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

(2009) S. L. Thein et al.   HUMAN MOLECULAR GENETICS

Adherence to Hydroxyurea Therapy in Children with Sickle Cell Anemia

(2009) Courtney D. Thornburg et al.   JOURNAL OF PEDIATRICS

The Xmn1 polymorphic site 5′ to the Gγ gene and its correlation to the Gγ:Aγ ratio, age at first blood transfusion and clinical features in β-Thalassemia patients from Western Iran

(2009) Hooshang Nemati et al.   MOLECULAR BIOLOGY REPORTS

Genetic Variation on Chromosome 6 Influences F Cell Levels in Healthy Individuals of African Descent and HbF Levels in Sickle Cell Patients

(2009) Lisa E. Creary et al.   PLoS One

Hydroxyurea in sickle cell disease—A study of clinico-pharmacological efficacy in the Indian haplotype

(2008) K ITALIA et al.   BLOOD CELLS MOLECULES AND DISEASES

Fetal haemoglobin response to hydroxycarbamide treatment and sar1a promoter polymorphisms in sickle cell anaemia

(2008) Chutima Kumkhaek et al.   BRITISH JOURNAL OF HAEMATOLOGY

Global epidemiology of haemoglobin disorders and derived service indicators

(2008) Bernadette Modell   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Influence of sickle cell disease and treatment with hydroxyurea on sperm parameters and fertility of human males

(2008) I. Berthaut et al.   HAEMATOLOGICA

Strides Made in Red Blood Cell Disorders, but Substantial Barriers to Care Remain

(2008) Tracy Hampton   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A pilot study of hydroxyurea to prevent chronic organ damage in young children with sickle cell anemia

(2008) Courtney D. Thornburg et al.   PEDIATRIC BLOOD & CANCER

Hydroxyurea for Sickle Cell Disease: A Systematic Review for Efficacy and Toxicity in Children

(2008) J. J. Strouse et al.   PEDIATRICS

The Genomic Analysis of Erythrocyte microRNA Expression in Sickle Cell Diseases

(2008) Shao-Yin Chen et al.   PLoS One

Genetic complexity in sickle cell disease

(2008) D. R. Higgs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymorphisms at the BCL11A, HBS1L-MYB, and  -globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease

(2008) G. Lettre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific RepressorBCL11A

(2008) Vijay G. Sankaran et al.   SCIENCE

DNA damage in blood leukocytes of individuals with sickle cell disease treated with hydroxyurea

(2007) João Ricardo Friedrisch et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS