Restoration of Sarcoplasmic Reticulum Ca2+ ATPase (SERCA) Activity Prevents Age-Related Muscle Atrophy and Weakness in Mice

Sarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in Drosophila

(2020) Alba Delrio-Lorenzo et al.   JOURNAL OF CELL SCIENCE

Improved Calcium Homeostasis and Force by Selenium Treatment and Training in Aged Mouse Skeletal Muscle

(2020) János Fodor et al.   Scientific Reports

Muscle unloading: A comparison between spaceflight and ground‐based models

(2019) Rizwan Qaisar et al.   Acta Physiologica

A new target for Alzheimer’s disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice

(2018) Katherine Krajnak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Skeletal muscle mass is controlled by the MRF4–MEF2 axis

(2018) Stefano Schiaffino et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

(2018) Derek T Hall et al.   EMBO Molecular Medicine

Etoposide-induced protein 2.4 functions as a regulator of the calcium ATPase and protects pancreatic β-cell survival

(2018) Lin Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skeletal muscle in aged mice reveals extensive transformation of muscle gene expression

(2018) I-Hsuan Lin et al.   BMC GENETICS

A role for calcium in resistin transcriptional activation in diabetic hearts

(2018) Rajvir Singh et al.   Scientific Reports

Oxidative stress-induced dysregulation of excitation-contraction coupling contributes to muscle weakness

(2018) Rizwan Qaisar et al.   Journal of Cachexia Sarcopenia and Muscle

Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness

(2018) Rizwan Qaisar et al.   Redox Biology

Mitochondria Initiate and Regulate Sarcopenia

(2017) Stephen E. Alway et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Reducing sarcolipin expression mitigates Duchenne muscular dystrophy and associated cardiomyopathy in mice

(2017) Antanina Voit et al.   Nature Communications

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

(2016) Sébastien S. Dufresne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mitochondrial Ca2+ uptake in skeletal muscle health and disease

(2016) Jingsong Zhou et al.   Science China-Life Sciences

SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models

(2015) Davi A. G. Mázala et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Small Molecular Allosteric Activator of the Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) Attenuates Diabetes and Metabolic Disorders

(2015) Soojeong Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of calcium homeostasis in muscular dystrophies

(2014) Ainara Vallejo-Illarramendi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Lysosomal storage diseases and the heat shock response: convergences and therapeutic opportunities

(2014) Linda Ingemann et al.   JOURNAL OF LIPID RESEARCH

p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice

(2014) Jennifer D Bernet et al.   NATURE MEDICINE

Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production

(2013) Cyril Nii-Klu Adjeitey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Molecularly Distinct Routes of Mitochondrial Ca2+Uptake Are Activated Depending on the Activity of the Sarco/Endoplasmic Reticulum Ca2+ATPase (SERCA)

(2013) Markus Waldeck-Weiermair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca2+ and reactive oxygen species signaling

(2013) V. Eisner et al.   JOURNAL OF CELL SCIENCE

Heat Shock Transcription Factor 1-Deficiency Attenuates Overloading-Associated Hypertrophy of Mouse Soleus Muscle

(2013) Tomoyuki Koya et al.   PLoS One

Ryanodine Receptor Oxidation Causes Intracellular Calcium Leak and Muscle Weakness in Aging

(2011) Daniel C. Andersson et al.   Cell Metabolism

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

(2011) Sanjeewa A. Goonasekera et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors

(2011) Fujun Chen et al.   NATURE NEUROSCIENCE

Effects of aging and gender on the spatial organization of nuclei in single human skeletal muscle cells

(2010) Alexander Cristea et al.   AGING CELL

Initiating treadmill training in late middle age offers modest adaptations in Ca2+ handling but enhances oxidative damage in senescent rat skeletal muscle

(2010) Melissa M. Thomas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Sarcopenia: characteristics, mechanisms and functional significance

(2010) M. V. Narici et al.   BRITISH MEDICAL BULLETIN

Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration

(2009) Youngmok C. Jang et al.   FASEB JOURNAL

Sarcopenia: etiology, clinical consequences, intervention, and assessment

(2009) T. Lang et al.   OSTEOPOROSIS INTERNATIONAL

Reduction of mitochondrial H2O2by overexpressing peroxiredoxin 3 improves glucose tolerance in mice

(2008) Liuji Chen et al.   AGING CELL

Denervation Induces Cytosolic Phospholipase A2-mediated Fatty Acid Hydroperoxide Generation by Muscle Mitochondria

(2008) Arunabh Bhattacharya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY