Development of subnanomolar radiofluorinated (2-pyrrolidin-1-yl)imidazo[1,2-b]pyridazine pan-Trk inhibitors as candidate PET imaging probes

(R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors

(2015) Ha-Soon Choi et al.   ACS Medicinal Chemistry Letters

Syntheses and Evaluation of Carbon-11- and Fluorine-18-Radiolabeled pan-Tropomyosin Receptor Kinase (Trk) Inhibitors: Exploration of the 4-Aza-2-oxindole Scaffold as Trk PET Imaging Agents

(2014) Vadim Bernard-Gauthier et al.   ACS Chemical Neuroscience

5-(4-((4-[18F]fluorobenzyl)oxy)-3-methoxybenzyl)pyrimidine-2,4-diamine: A selective dual inhibitor for potential PET imaging of Trk/CSF-1R

(2014) Vadim Bernard-Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

TrkB inhibition by GNF-4256 slows growth and enhances chemotherapeutic efficacy in neuroblastoma xenografts

(2014) Jamie L. Croucher et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Tropomyosin receptor kinase inhibitors: a patent update 2009 – 2013

(2014) Clive McCarthy et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

(2014) Shawn J. Stachel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Spirocyclic hypervalent iodine(III)-mediated radiofluorination of non-activated and hindered aromatics

(2014) Benjamin H. Rotstein et al.   Nature Communications

Iodonium ylides for one-step, no-carrier-added radiofluorination of electron rich arenes, exemplified with 4-(([18F]fluorophenoxy)-phenylmethyl)piperidine NET and SERT ligands

(2014) Jens Cardinale et al.   RSC Advances

Towards tropomyosin-related kinase B (TrkB) receptor ligands for brain imaging with PET: Radiosynthesis and evaluation of 2-(4-[18F]fluorophenyl)-7,8-dihydroxy-4H-chromen-4-one and 2-(4-([N-methyl-11C]-dimethylamino)phenyl)-7,8-dihydroxy-4H-chromen-4-one

(2013) Vadim Bernard-Gauthier et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand

(2013) Lei Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Investigations into the synthesis, radiofluorination and conjugation of a new [18F]fluorocyclobutyl prosthetic group and its in vitro stability using a tyrosine model system

(2012) Dominic Franck et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Truncated TrkB: Beyond a dominant negative receptor

(2012) Barbara M. Fenner   CYTOKINE & GROWTH FACTOR REVIEWS

Roles of brain-derived neurotrophic factor/tropomyosin-related kinase B (BDNF/TrkB) signalling in Alzheimer’s disease

(2012) Fang Zhang et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Copper-mediated reduction of 2-[18F]fluoroethyl azide to 2-[18F]fluoroethylamine

(2012) Matthias Glaser et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition

(2012) T. Bertrand et al.   JOURNAL OF MOLECULAR BIOLOGY

Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models

(2012) Pam Albaugh et al.   ACS Medicinal Chemistry Letters

Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

(2011) Patrick W. Mantyh et al.   ANESTHESIOLOGY

5-HT radioligands for human brain imaging with PET and SPECT

(2011) Louise M. Paterson et al.   MEDICINAL RESEARCH REVIEWS

Administration of a Tropomyosin Receptor Kinase Inhibitor Attenuates Sarcoma-Induced Nerve Sprouting, Neuroma Formation and Bone Cancer Pain

(2010) Joseph R Ghilardi et al.   Molecular Pain

Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation

(2009) Grace Sophia Griesbach et al.   BRAIN RESEARCH

On Trk--The TrkB Signal Transduction Pathway Is an Increasingly Important Target in Cancer Biology

(2009) C. J. Thiele et al.   CLINICAL CANCER RESEARCH

Trk Receptor Expression and Inhibition in Neuroblastomas

(2009) G. M. Brodeur et al.   CLINICAL CANCER RESEARCH

Trk kinase inhibitors as new treatments for cancer and pain

(2009) Tao Wang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Brain-Derived Neurotropic Factor/TrkB Signaling in the Pathogenesis and Novel Pharmacotherapy of Schizophrenia

(2008) Anilkumar Pillai   NEUROSIGNALS