5-HT radioligands for human brain imaging with PET and SPECT

Seasonal Changes in Brain Serotonin Transporter Binding in Short Serotonin Transporter Linked Polymorphic Region-Allele Carriers but Not in Long-Allele Homozygotes

(2010) Jan Kalbitzer et al.   BIOLOGICAL PSYCHIATRY

Serotonin 1B Receptor Imaging in Alcohol Dependence

(2010) Jian Hu et al.   BIOLOGICAL PSYCHIATRY

Looking for a 5-HT7 radiotracer for positron emission tomography

(2010) Julien Andriès et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel99mTc(CO)3Complexes with WAY-100635 Moiety for the Development of 5-HT1AReceptor lmaging Agent

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Acute treatment of migraine with the selective 5-HT1F receptor agonist lasmiditan – A randomised proof-of-concept trial

(2010) Michel D Ferrari et al.   CEPHALALGIA

Brainstem changes in 5-HT1A receptor availability during migraine attack

(2010) G Demarquay et al.   CEPHALALGIA

Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings

(2010) D.J. Veltman et al.   CURRENT PHARMACEUTICAL DESIGN

Recent Advances in the Discovery of Selective and Non-Selective 5-HT1D Receptor Ligands

(2010) Simon E. Ward et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Medicinal Chemistry of 5-HT5A Receptor Ligands: A Receptor Subtype with Unique Therapeutical Potential

(2010) Balazs Volk et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers

(2010) Anders Ettrup et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Measuring Endogenous 5-HT Release by Emission Tomography: Promises and Pitfalls

(2010) Louise M Paterson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In vivo Serotonin-Sensitive Binding of [11C]CUMI-101: A Serotonin 1A Receptor Agonist Positron Emission Tomography Radiotracer

(2010) Matthew S Milak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Quantitative Analysis of [11C]AZ10419369 Binding to 5-HT1B Receptors in Human Brain

(2010) Katarina Varnäs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

In Vivo Quantification of Human Serotonin 1A Receptor Using 11C-CUMI-101, an Agonist PET Radiotracer

(2010) M. S. Milak et al.   JOURNAL OF NUCLEAR MEDICINE

Radiosynthesis and Evaluation of 11C-CIMBI-5 as a 5-HT2A Receptor Agonist Radioligand for PET

(2010) A. Ettrup et al.   JOURNAL OF NUCLEAR MEDICINE

A Comparative Evaluation of the Dopamine D2/3 Agonist Radiotracer [11C](-)-N-Propyl-norapomorphine and Antagonist [11C]Raclopride to Measure Amphetamine-Induced Dopamine Release in the Human Striatum

(2010) R. Narendran et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Simplified quantification of 5-HT2A receptors in the human brain with [11C]MDL 100,907 PET and non-invasive kinetic analyses

(2010) Philipp T. Meyer et al.   NEUROIMAGE

Evaluation of the in vivo ED50 for the PET Radioligand, [11C]GSK-215083, in Papio anubis

(2010) Christine A. Parker et al.   NEUROIMAGE

Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET

(2010) Lisbeth Marner et al.   NEUROIMAGE

18F-Labeling and evaluation of novel MDL 100907 derivatives as potential 5-HT2A antagonists for molecular imaging

(2010) Fabian Debus et al.   NUCLEAR MEDICINE AND BIOLOGY

Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder

(2010) James W. Murrough et al.   PSYCHOPHARMACOLOGY

Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine

(2010) Hans Rasmussen et al.   PSYCHOPHARMACOLOGY

The role of dorsal raphe nucleus serotonergic and non-serotonergic neurons, and of their receptors, in regulating waking and rapid eye movement (REM) sleep

(2010) Jaime M. Monti   SLEEP MEDICINE REVIEWS

In vivo kinetics of [F-18]MEFWAY: A comparison with [C-11]WAY100635 and [F-18]MPPF in the nonhuman primate

(2010) D.W. Wooten et al.   SYNAPSE

Fenfluramine-induced serotonin release decreases [11C]AZ10419369 binding to 5-HT1B-receptors in the primate brain

(2010) S.J. Finnema et al.   SYNAPSE

Efficacy of 5-HT3 Antagonists and 5-HT4 Agonists in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis

(2009) Alexander C Ford et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

An improved synthesis of 4-[18F]-ADAM, a potent serotonin transporter imaging agent

(2009) Ya-Yao Huang et al.   APPLIED RADIATION AND ISOTOPES

Positron Emission Tomography Quantification of Serotonin-1A Receptor Binding in Medication-Free Bipolar Depression

(2009) Gregory M. Sullivan et al.   BIOLOGICAL PSYCHIATRY

Genetic Variation in Brain-Derived Neurotrophic Factor Is Associated with Serotonin Transporter but Not Serotonin-1A Receptor Availability in Men

(2009) Susanne Henningsson et al.   BIOLOGICAL PSYCHIATRY

The Serotonin-1A Receptor in Anxiety Disorders

(2009) Elena Akimova et al.   BIOLOGICAL PSYCHIATRY

Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET

(2009) Matthias M. Herth et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Signal transduction and functional selectivity of F15599, a preferential post-synaptic 5-HT1Areceptor agonist

(2009) A Newman-Tancredi et al.   BRITISH JOURNAL OF PHARMACOLOGY

The 5-HT1B Receptor: A Novel Target for the Pathophysiology of Depression (Supplementary Tables)

(2009) B. Ruf et al.   CURRENT DRUG TARGETS

Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys

(2009) Ya-Yao Huang et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

[18F]F15599, a novel 5-HT1A receptor agonist, as a radioligand for PET neuroimaging

(2009) Laëtitia Lemoine et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Differential influence of selective 5-HT5A vs 5-HT1A, 5-HT1B, or 5-HT2C receptor blockade upon light-induced phase shifts in circadian activity rhythms: Interaction studies with citalopram

(2009) Robert L. Gannon et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Molecular tools for assessing human depression by positron emission tomography

(2009) Donald F. Smith et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Kinetic Modeling of the Serotonin 5-HT1B Receptor Radioligand [11C]P943 in Humans

(2009) Jean-Dominique Gallezot et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Parametric Mapping of 5HT1A Receptor Sites in the Human Brain with the Hypotime Method: Theory and Normal Values

(2009) M. Moller et al.   JOURNAL OF NUCLEAR MEDICINE

Kinetic Modeling of 11C-SB207145 Binding to 5-HT4 Receptors in the Human Brain In Vivo

(2009) L. Marner et al.   JOURNAL OF NUCLEAR MEDICINE

[N-methyl-3H3]AZ10419369 Binding to the 5-HT1B Receptor: In Vitro Characterization and in Vivo Receptor Occupancy

(2009) D. L. Maier et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Effects of amyloid-β peptides on the serotoninergic 5-HT1A receptors in the rat hippocampus

(2009) Mathieu Verdurand et al.   NEUROBIOLOGY OF AGING

Validation of 4-[18F]-ADAM as a SERT imaging agent using micro-PET and autoradiography

(2009) Kuo-Hsing Ma et al.   NEUROIMAGE

Brain serotonin 2A receptor binding: Relations to body mass index, tobacco and alcohol use

(2009) D. Erritzoe et al.   NEUROIMAGE

High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding

(2009) Vibe G. Frokjaer et al.   NEUROIMAGE

Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding

(2009) Vibe G Frokjaer et al.   NEUROPSYCHOPHARMACOLOGY

Gender and the use of hormonal contraception in women are not associated with cerebral cortical 5-HT 2A receptor binding

(2009) V.G. Frokjaer et al.   NEUROSCIENCE

Preliminary in vivo and ex vivo evaluation of the 5-HT2A imaging probe [18F]MH.MZ

(2009) Matthias M. Herth et al.   NUCLEAR MEDICINE AND BIOLOGY

High-resolution imaging of brain 5-HT1B receptors in the rhesus monkey using [11C]P943

(2009) Nabeel Nabulsi et al.   NUCLEAR MEDICINE AND BIOLOGY

Metabolic side effects of antipsychotic drug treatment – pharmacological mechanisms

(2009) Gavin P Reynolds et al.   PHARMACOLOGY & THERAPEUTICS

5-HT1A receptor and 5-HTT binding during the menstrual cycle in healthy women examined with [11C] WAY100635 and [11C] MADAM PET

(2009) Hristina Jovanovic et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Regional distribution and behavioral correlates of 5-HT2A receptors in Alzheimer's disease with [18F]deuteroaltanserin and PET

(2009) Lekshmi Santhosh et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Reported childhood abuse is associated with low serotonin transporter binding in vivo in major depressive disorder

(2009) Jeffrey M. Miller et al.   SYNAPSE

Psychedelics and schizophrenia

(2009) Javier González-Maeso et al.   TRENDS IN NEUROSCIENCES

PET radiotracers: crossing the blood–brain barrier and surviving metabolism

(2009) Victor W. Pike   TRENDS IN PHARMACOLOGICAL SCIENCES

Synthesis and biological evaluation of 99mTc-HEDTA/HYNIC-MPP4 complex for 5-HT1A receptor imaging

(2009) WeiWei Fan et al.   Science in China. Series B, Chemistry

Molecular biology of 5-HT receptors

(2008) Jason Hannon et al.   BEHAVIOURAL BRAIN RESEARCH

Decreased [18F]MPPF Binding Potential in the Dorsal Raphe Nucleus After a Single Oral Dose of Fluoxetine: A Positron-Emission Tomography Study in Healthy Volunteers

(2008) Igor Sibon et al.   BIOLOGICAL PSYCHIATRY

Comorbidity between temporal lobe epilepsy and depression: a [18 F]MPPF PET study

(2008) A. Lothe et al.   BRAIN

Serotonin 5-HT1A receptor binding in people with panic disorder: positron emission tomography study

(2008) Jon R. Nash et al.   BRITISH JOURNAL OF PSYCHIATRY

Interictal Brain 5-HT1A Receptors Binding in Migraine Without Aura: A 18F-MPPF-PET Study

(2008) A Lothe et al.   CEPHALALGIA

The Role of 5-HT3 Receptors in Drug Abuse and as a Target for Pharmacotherapy

(2008) E. Engleman et al.   CNS & Neurological Disorders-Drug Targets

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

(2008) S. Syvanen et al.   DRUG METABOLISM AND DISPOSITION

18F-FCWAY and 18F-FDG PET in MRI-negative temporal lobe epilepsy

(2008) Clarissa J. Liew et al.   EPILEPSIA

Cyclosporine, a P-glycoprotein modulator, increases [18F]MPPF uptake in rat brain and peripheral tissues: microPET and ex vivo studies

(2008) Goran Laćan et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study

(2008) Lisbeth Marner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Evaluation of the Novel 5-HT4 Receptor PET Ligand [11C]SB207145 in the Göttingen Minipig

(2008) Birgitte R Kornum et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

N-[3-[4-(2-methoxyphenyl) piperaziny-1-yl]propyl]cyclam: synthesized as a potential 5-HT1Areceptor ligand and labelled with99mTc-nitrido core

(2008) Fenglong Wang et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Synthesis, labelling and first evaluation of [18F]R91150 as a serotonin 5-HT2Areceptor antagonist for PET

(2008) Ute Mühlhausen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Loss of thalamic serotonin transporters in early drug-naïve Parkinson’s disease patients is associated with tremor: an [123I]β-CIT SPECT study

(2008) V. Caretti et al.   JOURNAL OF NEURAL TRANSMISSION

Decreased blood–brain barrier P-glycoprotein function in the progression of Parkinson’s disease, PSP and MSA

(2008) A. L. Bartels et al.   JOURNAL OF NEURAL TRANSMISSION

Modeling Considerations for 11C-CUMI-101, an Agonist Radiotracer for Imaging Serotonin 1A Receptor In Vivo with PET

(2008) M. S. Milak et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation of the Serotonin Transporter Ligand 123I-ADAM for SPECT Studies on Humans

(2008) V. G. Frokjaer et al.   JOURNAL OF NUCLEAR MEDICINE

Anxiety is associated with reduced central serotonin transporter availability in unmedicated patients with unipolar major depression: a [11C]DASB PET study

(2008) M Reimold et al.   MOLECULAR PSYCHIATRY

Targeting the murine serotonin transporter: insights into human neurobiology

(2008) Dennis L. Murphy et al.   NATURE REVIEWS NEUROSCIENCE

In vivo PET study of 5HT2A serotonin and D2 dopamine dysfunction in drug-naive obsessive-compulsive disorder

(2008) Daniela Perani et al.   NEUROIMAGE

Evaluation of the novel 5-HT6 receptor radioligand, [11C]GSK-215083 in human

(2008) Christine A. Parker et al.   NEUROIMAGE

[11C]AZ10419369: A selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain

(2008) M. Edward Pierson et al.   NEUROIMAGE

The personality trait openness is related to cerebral 5-HTT levels

(2008) Jan Kalbitzer et al.   NEUROIMAGE

Changes in Thalamus–Hypothalamus Serotonin Transporter Availability during Clomipramine Administration in Patients with Obsessive–Compulsive Disorder

(2008) Werner Zitterl et al.   NEUROPSYCHOPHARMACOLOGY

Cortical and Subcortical 5-HT2A Receptor Binding in Neuroleptic-Naive First-Episode Schizophrenic Patients

(2008) David Erritzoe et al.   NEUROPSYCHOPHARMACOLOGY

In vivo evaluation in rodents of [123I]-3-I-CO as a potential SPECT tracer for the serotonin 5-HT2A receptor

(2008) Peter B.M. Blanckaert et al.   NUCLEAR MEDICINE AND BIOLOGY

123I-ADAM SPECT imaging of serotonin transporter binding in patients with Night Eating Syndrome: A preliminary report

(2008) Jennifer D. Lundgren et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

A role for the 5-HT1A, 5-HT4 and 5-HT6 receptors in learning and memory

(2008) M KING et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Realizing the potential of positron emission tomography with 18F-fluorodeoxyglucose to improve the treatment of Alzheimer’s disease

(2007) Norman L. Foster et al.   Alzheimers & Dementia

An automated synthesis of N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) for imaging serotonin transporters

(2007) Chi-Jiun Peng et al.   APPLIED RADIATION AND ISOTOPES

Frontolimbic Serotonin 2A Receptor Binding in Healthy Subjects Is Associated with Personality Risk Factors for Affective Disorder

(2007) Vibe G. Frokjaer et al.   BIOLOGICAL PSYCHIATRY

Total synthesis and evaluation of [18F]MHMZ

(2007) Matthias M. Herth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of new carbon-11 labeled benzoxazole derivatives for PET imaging of 5-HT3 receptor

(2007) Mingzhang Gao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Reduced 5-HT2A receptor binding in patients with mild cognitive impairment

(2007) S.G. Hasselbalch et al.   NEUROBIOLOGY OF AGING

An index of 5-HT synthesis changes during early antidepressant treatment: α-[11C]methyl-l-tryptophan PET study

(2007) Alexandre Berney et al.   NEUROCHEMISTRY INTERNATIONAL

The 5-HT2A receptor binding pattern in the human brain is strongly genetically determined

(2007) Lars H. Pinborg et al.   NEUROIMAGE

Sex differences in the serotonin 1A receptor and serotonin transporter binding in the human brain measured by PET

(2007) Hristina Jovanovic et al.   NEUROIMAGE