Synthesis and anti-cancer screening of novel heterocyclic-(2H)-1,2,3-triazoles as potential anti-cancer agents

Comparison of crystal structures of 4-(benzo[b]thiophen-2-yl)-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole and 4-(benzo[b]thiophen-2-yl)-2-methyl-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole

(2014) Narsimha Reddy Penthala et al.   ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE

An Organocatalytic Azide-Aldehyde [3+2] Cycloaddition: High-Yielding Regioselective Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

(2014) Dhevalapally B. Ramachary et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activity

(2014) Concepción Vilanova et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ce(OTf)3-Catalyzed [3 + 2] Cycloaddition of Azides with Nitroolefins: Regioselective Synthesis of 1,5-Disubstituted 1,2,3-Triazoles

(2014) Ying-Chun Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

DISRUPT: A randomised phase 2 trial of ombrabulin (AVE8062) plus a taxane–platinum regimen as first-line therapy for metastatic non-small cell lung cancer

(2014) Joachim von Pawel et al.   LUNG CANCER

l-Proline catalyzed one-step synthesis of 4,5-diaryl-2H-1,2,3-triazoles from heteroaryl cyanostilbenes via [3+2]cycloaddition of azide

(2014) Narsimha Reddy Penthala et al.   TETRAHEDRON LETTERS

Preparation of 4,5 disubstituted-2H-1,2,3-triazoles from (Z)-2,3-diaryl substituted acrylonitriles

(2014) Nikhil Reddy Madadi et al.   TETRAHEDRON LETTERS

Synthesis and evaluation of a series of quinolinyl trans-cyanostilbene analogs as anticancer agents

(2014) Narsimha Reddy Penthala et al.   MedChemComm

Synthesis and antiproliferative activity of conformationally restricted 1,2,3-triazole analogues of combretastatins in the sea urchin embryo model and against human cancer cell lines

(2013) Dmitry V. Demchuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines

(2013) Nikhil Reddy Madadi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crenolanib is active against models of drug-resistant FLT3-ITD-positive acute myeloid leukemia

(2013) E. I. Zimmerman et al.   BLOOD

Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents

(2013) Narsimha Reddy Penthala et al.   MedChemComm

Increased endothelial cell selectivity of triazole-bridged dihalogenated A-ring analogues of combretastatin A–1

(2012) Thomas M. Beale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phase I Trial of Combretastatin A4 Phosphate (CA4P) in Combination with Bevacizumab in Patients with Advanced Cancer

(2012) P. Nathan et al.   CLINICAL CANCER RESEARCH

The vascular disrupting agent ombrabulin (AVE8062) enhances the efficacy of standard therapies in head and neck squamous cell carcinoma xenograft models

(2012) Céline Clémenson et al.   INVESTIGATIONAL NEW DRUGS

Thyroidectomy followed by fosbretabulin (CA4P) combination regimen appears to suggest improvement in patient survival in anaplastic thyroid cancer

(2012) Julie A. Sosa et al.   SURGERY

Synthesis, biological evaluation and molecular modeling of 1,2,3-triazole analogs of combretastatin A-1

(2011) Øyvind W. Akselsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1,2,3-Triazole analogs of combretastatin A-4 as potential microtubule-binding agents

(2010) Kristin Odlo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Leukemia regression by vascular disruption and antiangiogenic therapy

(2010) G. J. Madlambayan et al.   BLOOD

Synthesis and Antitumor Activity of 1,5-Disubstituted 1,2,4-Triazoles as Cis-Restricted Combretastatin Analogues

(2010) Romeo Romagnoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

BNC105: A Novel Tubulin Polymerization Inhibitor That Selectively Disrupts Tumor Vasculature and Displays Single-Agent Antitumor Efficacy

(2010) G. Kremmidiotis et al.   MOLECULAR CANCER THERAPEUTICS

Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin

(2009) G. Kuznetsov et al.   MOLECULAR CANCER THERAPEUTICS

1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin

(2008) Kristin Odlo et al.   BIOORGANIC & MEDICINAL CHEMISTRY