Integration of microfluidic LC with HRMS for the analysis of analytes in biofluids: past, present and future

Generic Automated Method for Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry Based Monoclonal Antibody Quantitation for Preclinical Pharmacokinetic Studies

(2014) Qian Zhang et al.   ANALYTICAL CHEMISTRY

A Nano Ultra-Performance Liquid Chromatography–High Resolution Mass Spectrometry Approach for Global Metabolomic Profiling and Case Study on Drug-Resistant Multiple Myeloma

(2014) Drew R. Jones et al.   ANALYTICAL CHEMISTRY

Ion Mobility-Derived Collision Cross Section As an Additional Measure for Lipid Fingerprinting and Identification

(2014) Giuseppe Paglia et al.   ANALYTICAL CHEMISTRY

Metabolic Phenotyping Reveals a Lipid Mediator Response to Ionizing Radiation

(2014) Evagelia C. Laiakis et al.   JOURNAL OF PROTEOME RESEARCH

A Protective Lipidomic Biosignature Associated with a Balanced Omega-6/Omega-3 Ratio in fat-1 Transgenic Mice

(2014) Giuseppe Astarita et al.   PLoS One

The application of a new microfluidic device for the simultaneous identification and quantitation of midazolam metabolites obtained from a single micro-litre of chimeric mice blood

(2014) Richard Gallagher et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Advances in liquid chromatography coupled to mass spectrometry for metabolic phenotyping

(2014) Paul D. Rainville et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Application of high-resolution MS in the quantification of a therapeutic monoclonal antibody in human plasma

(2014) Kevork Mekhssian et al.   Bioanalysis

Liquid chromatography/time-of-flight mass spectrometry analysis of postmortem blood samples for targeted toxicological screening

(2013) Markus Roman et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Isomer-specific chromatographic profiling yields highly sensitive and specific potential N-glycan biomarkers for epithelial ovarian cancer

(2013) Serenus Hua et al.   JOURNAL OF CHROMATOGRAPHY A

Multiplexed analysis of steroid hormones in human serum using novel microflow tile technology and LC–MS/MS

(2013) Carolyn J. Broccardo et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Comparison of high-resolution and tandem mass spectrometry for the analysis of nerve agent metabolites in urine

(2013) Elizabeth I. Hamelin et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Validation of hepcidin quantification in plasma using LC–HRMS and discovery of a new hepcidin isoform

(2013) Bertrand Rochat et al.   Bioanalysis

Determination of rosiglitazone and 5-hydroxy rosiglitazone in rat plasma using LC–HRMS by direct and indirect quantitative analysis: a new approach for metabolite quantification

(2013) Jian Jiang et al.   Bioanalysis

Large-molecule quantification: sensitivity and selectivity head-to-head comparison of triple quadrupole with Q-TOF

(2013) Louis-Philippe Morin et al.   Bioanalysis

Applications of high-resolution MS in bioanalysis

(2013) Mike-Qingtao Huang et al.   Bioanalysis

A reversed-phase capillary ultra-performance liquid chromatography–mass spectrometry (UPLC-MS) method for comprehensive top-down/bottom-up lipid profiling

(2012) Xiaoli Gao et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Multiple Precursor Ion Scanning of Gangliosides and Sulfatides with a Reversed-Phase Microfluidic Chip and Quadrupole Time-of-Flight Mass Spectrometry

(2012) Hyeyoung Lee et al.   ANALYTICAL CHEMISTRY

A validated microfluidics-based LC-chip-MS/MS method for the quantitation of fluoxetine and norfluoxetine in rat serum

(2012) Virginie Houbart et al.   ELECTROPHORESIS

Comparison between a high-resolution single-stage Orbitrap and a triple quadrupole mass spectrometer for quantitative analyses of drugs

(2012) Hugues Henry et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Evaluation of the interrelationship between mass resolving power and mass error tolerances for targeted bioanalysis using liquid chromatography coupled to high-resolution mass spectrometry

(2012) A. Kaufmann et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides

(2012) Lieve Dillen et al.   Bioanalysis

LC–MS systems for quantitative bioanalysis

(2012) William D van Dongen et al.   Bioanalysis

Identification of Di-isononyl Phthalate Metabolites for Exposure Marker Discovery Using In Vitro/In Vivo Metabolism and Signal Mining Strategy with LC-MS Data

(2011) Jing-Fang Hsu et al.   ANALYTICAL CHEMISTRY

Performance Characteristics of a New Hybrid Quadrupole Time-of-Flight Tandem Mass Spectrometer (TripleTOF 5600)

(2011) Genna L. Andrews et al.   ANALYTICAL CHEMISTRY

Analytical Strategies for Assessment of Human Metabolites in Preclinical Safety Testing

(2011) Shuguang Ma et al.   ANALYTICAL CHEMISTRY

It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS

(2011) Ragu Ramanathan et al.   JOURNAL OF MASS SPECTROMETRY

Development of a Chip/Chip/SRM Platform Using Digital Chip Isoelectric Focusing and LC-Chip Mass Spectrometry for Enrichment and Quantitation of Low Abundance Protein Biomarkers in Human Plasma

(2011) Agnes Rafalko et al.   JOURNAL OF PROTEOME RESEARCH

Targeted quantitative bioanalysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: an evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profile mo

(2011) Yuan-Qing Xia et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Multivariate methods in metabolomics – from pre-processing to dimension reduction and statistical analysis

(2011) Kristian Hovde Liland   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Addressing the challenge of limited sample volumes inin vitrostudies with capillary-scale microfluidic LC–MS/MS

(2011) Paul D Rainville et al.   Bioanalysis

Application of nano-LC-based glycomics towards biomarker discovery

(2011) Serenus Hua et al.   Bioanalysis

Characterization and evaluation of two-dimensional microfluidic chip-HPLC coupled to tandem mass spectrometry for quantitative analysis of 7-aminoflunitrazepam in human urine

(2010) Hsin-Yu Bai et al.   ANALYST

Quantitative Measurement of Plasma 3-Hydroxyisovaleryl Carnitine by LC-MS/MS as a Novel Biomarker of Biotin Status in Humans

(2010) Thomas D. Horvath et al.   ANALYTICAL CHEMISTRY

Simultaneous determination of polyamines in human nail as 4-(N,N-dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole derivatives by nano-flow chip LC coupled with quadrupole time-of-flight tandem mass spectrometry

(2010) Jun Zhe Min et al.   CLINICA CHIMICA ACTA

Quantitative determination of 8-isoprostaglandin F2α in human urine using microfluidic chip-based nano-liquid chromatography with on-chip sample enrichment and tandem mass spectrometry

(2010) Hsin-Yu Bai et al.   JOURNAL OF CHROMATOGRAPHY A

Proteomics on an Orbitrap Benchtop Mass Spectrometer Using All-ion Fragmentation

(2010) Tamar Geiger et al.   MOLECULAR & CELLULAR PROTEOMICS

Capillary separations in metabolomics

(2010) Wei Yuan et al.   Bioanalysis

Quantitative Phosphorus Metabolomics Using Nanoflow Liquid Chromatography-Tandem Mass Spectrometry and Culture-Derived Comprehensive Global Internal Standards

(2009) Taisuke Uehara et al.   ANALYTICAL CHEMISTRY

Quantitative Profiling of Polar Cationic Metabolites in Human Cerebrospinal Fluid by Reversed-Phase Nanoliquid Chromatography/Mass Spectrometry

(2009) Khin Than Myint et al.   ANALYTICAL CHEMISTRY

Polar Anionic Metabolome Analysis by Nano-LC/MS with a Metal Chelating Agent

(2009) Khin Than Myint et al.   ANALYTICAL CHEMISTRY

Application of Ultra Performance Liquid Chromatography−Mass Spectrometry to Profiling Rat and Dog Bile

(2009) Robert S. Plumb et al.   JOURNAL OF PROTEOME RESEARCH

Microfluidic HPLC-Chip devices with integral channels containing methylstyrenic-based monolithic media

(2009) Karla M. Robotti et al.   JOURNAL OF SEPARATION SCIENCE

Profile of native N-linked glycan structures from human serum using high performance liquid chromatography on a microfluidic chip and time-of-flight mass spectrometry

(2009) Caroline S. Chu et al.   PROTEOMICS

Nano-LC and HPLC-chip–ESI–MS: an emerging technique for glycobioanalysis

(2009) Stephan Kirsch et al.   Bioanalysis

Improving Protein Identification Sensitivity by Combining MS and MS/MS Information for Shotgun Proteomics Using LTQ-Orbitrap High Mass Accuracy Data

(2008) Bingwen Lu et al.   ANALYTICAL CHEMISTRY

Quantification of NTproBNP in Rat Serum Using Immunoprecipitation and LC/MS/MS:  a Biomarker of Drug-Induced Cardiac Hypertrophy

(2008) Michael Berna et al.   ANALYTICAL CHEMISTRY

Spectroscopic and Statistical Techniques for Information Recovery in Metabonomics and Metabolomics

(2008) John C. Lindon et al.   Annual Review of Analytical Chemistry

Addressing the analytical throughput challenges in ADME screening using rapid ultra-performance liquid chromatography/tandem mass spectrometry methodologies

(2008) Robert S. Plumb et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

LC-MS-based methodology for global metabolite profiling in metabonomics/metabolomics

(2008) Georgios Theodoridis et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Fully Automated Four-Column Capillary LC−MS System for Maximizing Throughput in Proteomic Analyses

(2007) Eric A. Livesay et al.   ANALYTICAL CHEMISTRY