Bile acids target proteolipid nano-assemblies of EGFR and phosphatidic acid in the plasma membrane for stimulation of MAPK signaling

Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition

(2018) Natividad R. Fuentes et al.   CANCER RESEARCH

Replication of human noroviruses in stem cell-derived human enteroids

(2016) K. Ettayebi et al.   SCIENCE

TRP channels interaction with lipids and its implications in disease

(2015) Francisco J. Taberner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Interactions of the EGFR juxtamembrane domain with PIP 2 -containing lipid bilayers: Insights from multiscale molecular dynamics simulations

(2015) Khairul Bariyyah Abd Halim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Complementary probes reveal that phosphatidylserine is required for the proper transbilayer distribution of cholesterol

(2015) M. Maekawa et al.   JOURNAL OF CELL SCIENCE

Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology

(2015) Kapil Saxena et al.   JOURNAL OF VIROLOGY

Interaction of Cytotoxic and Cytoprotective Bile Acids with Model Membranes: Influence of the Membrane Composition

(2015) M. Esteves et al.   LANGMUIR

Membrane potential modulates plasma membrane phospholipid dynamics and K-Ras signaling

(2015) Y. Zhou et al.   SCIENCE

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF- : Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

(2014) N. S. Nagathihalli et al.   CANCER RESEARCH

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

(2014) TinaMarie Lieu et al.   GASTROENTEROLOGY

Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades

(2014) Alan F. Hofmann et al.   JOURNAL OF LIPID RESEARCH

Bile acids are nutrient signaling hormones

(2014) Huiping Zhou et al.   STEROIDS

Secondary bile acids: an underrecognized cause of colon cancer

(2014) Hana Ajouz et al.   World Journal of Surgical Oncology

Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations

(2013) João Mello-Vieira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Bile Acids Modulate Signaling by Functional Perturbation of Plasma Membrane Domains

(2013) Yong Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determination of bile salt critical micellization concentration on the road to drug discovery

(2013) Benedetto Natalini et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Temporal Production of the Signaling Lipid Phosphatidic Acid by Phospholipase D2 Determines the Output of Extracellular Signal-Regulated Kinase Signaling in Cancer Cells

(2013) F. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor

(2012) Chafen Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The epidermal growth factor receptor conundrum

(2010) Jason A. Wilken et al.   CANCER

Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment To Induce Nanocluster Formation

(2010) N. Ariotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

(2010) B. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE