Running wheel exercise reduces α-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson's disease

Treadmill exercise decreases amyloid-β burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimer's disease

(2017) Jung-Hoon Koo et al.   EXPERIMENTAL NEUROLOGY

The two-century journey of Parkinson disease research

(2017) Serge Przedborski   NATURE REVIEWS NEUROSCIENCE

Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome

(2017) Yi Yang et al.   PLoS One

Selective lowering of synapsins induced by oligomeric α-synuclein exacerbates memory deficits

(2017) Megan E. Larson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors

(2016) Carlos Campos et al.   Expert Review of Neurotherapeutics

Effects of Physical-Exercise-Based Rehabilitation Programs on the Quality of Life of Patients With Parkinson’s Disease: A Systematic Review of Randomized Controlled Trials

(2016) Franciele Cascaes da Silva et al.   JOURNAL OF AGING AND PHYSICAL ACTIVITY

The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease

(2016) Matthew J. Benskey et al.   JOURNAL OF NEUROCHEMISTRY

Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

A spectrum of exercise training reduces soluble Aβ in a dose-dependent manner in a mouse model of Alzheimer's disease

(2016) Kaitlin M. Moore et al.   NEUROBIOLOGY OF DISEASE

Running rewires the neuronal network of adult-born dentate granule cells

(2016) Carmen Vivar et al.   NEUROIMAGE

Treadmill exercise facilitates synaptic plasticity on dopaminergic neurons and fibers in the mouse model with Parkinson’s disease

(2016) Mal-Soon Shin et al.   NEUROSCIENCE LETTERS

The Effects of Physical Activity in Parkinson’s Disease: A Review

(2016) Martine Lauzé et al.   Journal of Parkinsons Disease

Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors

(2016) Carlos Campos et al.   Expert Review of Neurotherapeutics

Running Exercise Reduces Myelinated Fiber Loss in the Dentate Gyrus of the Hippocampus in APP/PS1 Transgenic Mice

(2015) Fenglei Chao et al.   Current Alzheimer Research

Treadmill exercise activates Nrf2 antioxidant system to protect the nigrostriatal dopaminergic neurons from MPP+ toxicity

(2015) Yi-Hsien Tsou et al.   EXPERIMENTAL NEUROLOGY

Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease

(2015) Ravindran Kumaran et al.   HUMAN MOLECULAR GENETICS

Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6/1 model of Huntington’s disease

(2015) E.A.F. Herbst et al.   NEUROSCIENCE

The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson’s disease

(2015) J. Schapansky et al.   NEUROSCIENCE

Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6/1 Huntington's disease mouse model

(2013) David J. Harrison et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein and Mitochondrial Dysfunction in Parkinson’s Disease

(2013) Stephen Mullin et al.   MOLECULAR NEUROBIOLOGY

Treadmill exercise reverses dendritic spine loss in direct and indirect striatal medium spiny neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease

(2013) William A. Toy et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effects of swimming training in a mouse model of Parkinson’s disease induced by 6-hydroxydopamine

(2013) A.T.R. Goes et al.   NEUROSCIENCE

Exercise: Is it a neuroprotective and if so, how does it work?

(2013) Michael J. Zigmond et al.   PARKINSONISM & RELATED DISORDERS

Genetics of Parkinson's disease – state of the art, 2013

(2013) Vincenzo Bonifati   PARKINSONISM & RELATED DISORDERS

Bridging animal and human models of exercise-induced brain plasticity

(2013) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice

(2012) Michael W. Marlatt et al.   Developmental Neurobiology

DJ-1 induces thioredoxin 1 expression through the Nrf2 pathway

(2012) Joo-Young Im et al.   HUMAN MOLECULAR GENETICS

YajL, the Prokaryotic Homolog of the Parkinsonism-Associated Protein DJ-1, Protects Cells against Protein Sulfenylation

(2012) Valérie Gautier et al.   JOURNAL OF MOLECULAR BIOLOGY

Emerging Role of Neuronal Exosomes in the Central Nervous System

(2012) Mathilde Chivet et al.   Frontiers in Physiology

Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease

(2011) Wenbo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

“Brain training” improves cognitive performance and survival in a transgenic mouse model of Huntington's disease

(2011) Nigel I. Wood et al.   NEUROBIOLOGY OF DISEASE

A Plant DJ-1 Homolog Is Essential for Arabidopsis thaliana Chloroplast Development

(2011) Jiusheng Lin et al.   PLoS One

Exercise effects on motor and affective behavior and catecholamine neurochemistry in the MPTP-lesioned mouse

(2010) Lori M. Gorton et al.   BEHAVIOURAL BRAIN RESEARCH

Exercise protects against MPTP-induced neurotoxicity in mice

(2010) Kimberly M. Gerecke et al.   BRAIN RESEARCH

Keap1-Nrf2 activation in the presence and absence of DJ-1

(2010) Li Gan et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Parkinson's disease: insights from pathways

(2010) M. R. Cookson et al.   HUMAN MOLECULAR GENETICS

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Exercise exerts neuroprotective effects on Parkinson's disease model of rats

(2009) Naoki Tajiri et al.   BRAIN RESEARCH

Exercise programs improve mobility and balance in people with Parkinson's disease

(2009) Lilian T.B. Gobbi et al.   PARKINSONISM & RELATED DISORDERS

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

(2009) S. Vasseur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Effect of Exercise Training in Improving Motor Performance and Corticomotor Excitability in People With Early Parkinson's Disease

(2008) Beth E. Fisher et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

Transgenic Mice Overexpressing Tyrosine-to-Cysteine Mutant Human α-Synuclein

(2008) Wenbo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY