T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab

Dual role of ALCAM in neuroinflammation and blood–brain barrier homeostasis

(2017) Marc-André Lécuyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD6 as a potential target for treating multiple sclerosis

(2017) Yan Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Targeting of CD6 in Autoimmune Diseases: A Review of Cuban Clinical Studies with the Antibodies IOR-T1 and Itolizumab

(2016) Patricia Hernández et al.   CURRENT DRUG TARGETS

Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor

(2016) Adelaida Sarukhan et al.   CURRENT DRUG TARGETS

Editorial (Thematic Issues: Heads Or Tails: Betting On CD6 As a Resurged Target For Autoimmune Diseases and Sepsis)

(2016) Alexandre M. Carmo   CURRENT DRUG TARGETS

Tuning T Cell Activation: The Function of CD6 At the Immunological Synapse and in T Cell Responses

(2016) Rita F. Santos et al.   CURRENT DRUG TARGETS

CD6 as a Cell Surface Receptor and As a Target for Regulating Immune Responses

(2016) Marion H. Brown   CURRENT DRUG TARGETS

CD6 modulates thymocyte selection and peripheral T cell homeostasis

(2016) Marc Orta-Mascaró et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

(2016) Ying-Nan P. Chen et al.   NATURE

Anti-IL-17 Medications Used in the Treatment of Plaque Psoriasis and Psoriatic Arthritis: A Comprehensive Review

(2015) Theresa N. Canavan et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Secukinumab: A Review in Moderate to Severe Plaque Psoriasis

(2015) Karly P. Garnock-Jones   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

Itolizumab in combination with methotrexate modulates active rheumatoid arthritis: safety and efficacy from a phase 2, randomized, open-label, parallel-group, dose-ranging study

(2015) Arvind Chopra et al.   CLINICAL RHEUMATOLOGY

Clinical efficacy and safety of anti-IL-17 agents for the treatment of patients with psoriasis

(2015) Yan Chen et al.   Immunotherapy

Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction

(2015) Paul E. Chappell et al.   STRUCTURE

Understanding the CD28/CTLA-4 (CD152) Pathway and Its Implications for Costimulatory Blockade

(2014) D. Gardner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

(2014) T. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Regulation of IL-17 in Human CCR6+ Effector Memory T Cells

(2014) H. Liu et al.   JOURNAL OF IMMUNOLOGY

T Cell Activation Regulates CD6 Alternative Splicing by Transcription Dynamics and SRSF1

(2014) V. G. da Gloria et al.   JOURNAL OF IMMUNOLOGY

miR-20b Suppresses Th17 Differentiation and the Pathogenesis of Experimental Autoimmune Encephalomyelitis by Targeting ROR t and STAT3

(2014) E. Zhu et al.   JOURNAL OF IMMUNOLOGY

ALCAM and CD6 — multiple sclerosis risk factors

(2014) M. Wagner et al.   JOURNAL OF NEUROIMMUNOLOGY

High CD6 and low chemokine receptor expression on peripheral blood lymphocytes correlates with MRI gadolinium enhancement in MS

(2014) Anna Jurewicz et al.   JOURNAL OF NEUROIMMUNOLOGY

Efficacy and safety of itolizumab, a novel anti-CD6 monoclonal antibody, in patients with moderate to severe chronic plaque psoriasis: Results of a double-blind, randomized, placebo-controlled, phase-III study

(2014) D.S. Krupashankar et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Akt Phosphorylation and Regulation of Transketolase Is a Nodal Point for Amino Acid Control of Purine Synthesis

(2014) Arindam Saha et al.   MOLECULAR CELL

Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor–independent TCR signaling hub

(2014) Romain Roncagalli et al.   NATURE IMMUNOLOGY

Brodalumab, an Anti-IL17RA Monoclonal Antibody, in Psoriatic Arthritis

(2014) Philip J. Mease et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD6 as a Therapeutic Target in Autoimmune Diseases: Successes and Challenges

(2013) Mafalda Pinto et al.   BIODRUGS

Dynamic regulatory network controlling TH17 cell differentiation

(2013) Nir Yosef et al.   NATURE

Small molecule inhibitors of RORγt: Targeting Th17 cells and other applications

(2012) Jun R. Huh et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

CD6 and Syntaxin Binding Protein 6 Variants and Response to Tumor Necrosis Factor Alpha Inhibitors in Danish Patients with Rheumatoid Arthritis

(2012) Sophine B. Krintel et al.   PLoS One

CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation

(2011) J. de Wit et al.   BLOOD

CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

(2011) Marta I. Oliveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation

(2011) D. M. Kofler et al.   JOURNAL OF IMMUNOLOGY

Lyn-mediated SHP-1 recruitment to CD5 contributes to resistance to apoptosis of B-cell chronic lymphocytic leukemia cells

(2011) E Tibaldi et al.   LEUKEMIA

6thAnnual European Antibody Congress 2010

(2011) Alain Beck et al.   mAbs

CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction

(2010) P. Nair et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Aberrant expression of CD6 on B-cell subsets from patients with Sjögren’s syndrome

(2010) Ruby Alonso et al.   JOURNAL OF AUTOIMMUNITY

Validation of the CD6 and TNFRSF1A loci as risk factors for multiple sclerosis in Spain

(2010) Bhairavi Swaminathan et al.   JOURNAL OF NEUROIMMUNOLOGY

Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: Differing impact on CD8 T cell phenotype and responsiveness to restimulation

(2010) Yixin Li et al.   Journal of Translational Medicine

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-β

(2009) Luca Durelli et al.   ANNALS OF NEUROLOGY

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

(2009) Hui Shen et al.   ARTHRITIS AND RHEUMATISM

Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis

(2009) Verena Brucklacher-Waldert et al.   BRAIN

An overview of IL-17 function and signaling

(2008) Sarah L. Gaffen   CYTOKINE

Towards the Definition of a Chimpanzee and Human Conserved CD6 Domain 1 Epitope Recognized by T1 Monoclonal Antibody

(2008) Ruby Alonso et al.   HYBRIDOMA

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE