6thAnnual European Antibody Congress 2010

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

Analysis of Identity, Charge Variants, and Disulfide Isomers of Monoclonal Antibodies with Capillary Zone Electrophoresis in an Uncoated Capillary Column

(2010) Yan He et al.   ANALYTICAL CHEMISTRY

Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity

(2010) E. Mossner et al.   BLOOD

A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin

(2010) Geng Kou et al.   CANCER LETTERS

Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size

(2010) C. Zahnd et al.   CANCER RESEARCH

Anti-Transforming Growth Factor   Receptor II Antibody Has Therapeutic Efficacy against Primary Tumor Growth and Metastasis through Multieffects on Cancer, Stroma, and Immune Cells

(2010) Z. Zhong et al.   CLINICAL CANCER RESEARCH

Design of next-generation protein therapeutics

(2010) Justin Caravella et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Thromboembolic Events in Patients Treated with Anti-Angiogenic Drugs

(2010) Patrizia Ferroni et al.   Current Vascular Pharmacology

Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity

(2010) Jianying Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine-linked and Non-consensus Asparagine-linked Oligosaccharides Present in Human Recombinant Antibodies Define Novel Protein Glycosylation Motifs

(2010) John F. Valliere-Douglass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid and refined separation of human IgG2 disulfide isomers using superficially porous particles

(2010) Qian Wang et al.   JOURNAL OF SEPARATION SCIENCE

Golimumab

(2010) Sohini Mazumdar et al.   mAbs

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

(2010) Jennifer S. Michaelson et al.   mAbs

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-IgTM) molecules

(2010) Chengbin Wu et al.   mAbs

5th European Antibody Congress 2009

(2010) Alain Beck et al.   mAbs

Safety and immunotoxicity assessment of immunomodulatory monoclonal antibodies

(2010) Frank R. Brennan et al.   mAbs

Stability of IgG isotypes in serum

(2010) Ivan Correia   mAbs

Canakinumab

(2010) Eugen Dhimolea   mAbs

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization

(2010) Tomoyuki Igawa et al.   NATURE BIOTECHNOLOGY

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

(2010) Anas Younes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

(2010) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets

(2010) Robert H. E. Friesen et al.   PLoS One

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

(2010) Brian R. Miller et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Reduced elimination of IgG antibodies by engineering the variable region

(2010) T. Igawa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine

(2009) David Ouellette et al.   ANALYTICAL BIOCHEMISTRY

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Studies in serum support rapid formation of disulfide bond between unpaired cysteine residues in the VH domain of an immunoglobulin G1 molecule

(2009) D. Ouellette et al.   ANALYTICAL BIOCHEMISTRY

Determination of the Mechanism of Action of Anti-FasL Antibody by Epitope Mapping and Homology Modeling

(2009) Victor H. Obungu et al.   BIOCHEMISTRY

Integrated studies of biology: multiplexed imaging assays from molecules to man and back

(2009) Kevin W Eliceiri et al.   CURRENT OPINION IN BIOTECHNOLOGY

Optimization of Fc-mediated effector functions of monoclonal antibodies

(2009) William R Strohl   CURRENT OPINION IN BIOTECHNOLOGY

GlycoFi's technology to control the glycosylation of recombinant therapeutic proteins

(2009) Alain Beck et al.   Expert Opinion on Drug Discovery

Different ways to improve the clinical effectiveness of radioimmunotherapy in solid tumors

(2009) Jean-Francois Chatal et al.   Journal of Cancer Research and Therapeutics

Human IgG2 Antibodies against Epidermal Growth Factor Receptor Effectively Trigger Antibody-Dependent Cellular Cytotoxicity but, in Contrast to IgG1, Only by Cells of Myeloid Lineage

(2009) Tanja Schneider-Merck et al.   JOURNAL OF IMMUNOLOGY

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Use of antibodies and immunoconjugates for the therapy of more accessible cancers

(2008) Robert M. Sharkey et al.   ADVANCED DRUG DELIVERY REVIEWS

Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications

(2008) Matthias Miederer et al.   ADVANCED DRUG DELIVERY REVIEWS

Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms

(2008) Theresa Martinez et al.   BIOCHEMISTRY

Antibody fucosylation differentially impacts cytotoxicity mediated by NK and PMN effector cells

(2008) M. Peipp et al.   BLOOD

Engineered Antibodies of IgG1/IgG3 Mixed Isotype with Enhanced Cytotoxic Activities

(2008) A. Natsume et al.   CANCER RESEARCH

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

(2008) Jette Wypych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

(2008) Thomas M. Dillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phase III Trial of Consolidation Therapy With Yttrium-90–Ibritumomab Tiuxetan Compared With No Additional Therapy After First Remission in Advanced Follicular Lymphoma

(2008) Franck Morschhauser et al.   JOURNAL OF CLINICAL ONCOLOGY

Reirradiation and Concurrent Chemotherapy After Salvage Surgery: Pay Now or Pay Later

(2008) Stuart J. Wong et al.   JOURNAL OF CLINICAL ONCOLOGY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE