Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells

Incomplete Re-Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β-Cell Dedifferentiation

(2017) A. Neelankal John et al.   JOURNAL OF NEUROENDOCRINOLOGY

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells

(2016) Mahboubeh Daneshpajooh et al.   DIABETOLOGIA

Compensatory hyperinsulinemia in high-fat diet-induced obese mice is associated with enhanced insulin translation in islets

(2015) Ayumi Kanno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition

(2015) Z Meng et al.   ONCOGENE

Paternal allelic mutation at theKcnq1locus reduces pancreatic β-cell mass by epigenetic modification ofCdkn1c

(2015) Shun-ichiro Asahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet β cell mass in diabetes and how it relates to function, birth, and death

(2013) Gordon C. Weir et al.   Annals of the New York Academy of Sciences

Epigenetic Mechanisms Linking Diabetes and Synaptic Impairments

(2013) J. Wang et al.   DIABETES

 -Cell Failure in Type 2 Diabetes: A Case of Asking Too Much of Too Few?

(2013) S. Costes et al.   DIABETES

Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin

(2013) S. Asahara et al.   DIABETOLOGIA

Microarray Analysis of Novel Candidate Genes Responsible for Glucose-Stimulated Insulin Secretion in Mouse Pancreatic β Cell Line MIN6

(2013) Eiji Yamato et al.   PLoS One

Evidence for Early Defects in Insulin Sensitivity and Secretion Before the Onset of Glucose Dysregulation in Obese Youths: A Longitudinal Study

(2012) C. Giannini et al.   DIABETES

Control of beta cell function and proliferation in mice stimulated by small-molecule glucokinase activator under various conditions

(2012) A. Nakamura et al.   DIABETOLOGIA

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

(2012) M. Lundh et al.   DIABETOLOGIA

Evaluation of safety, pharmacokinetics, and efficacy of vorinostat, a histone deacetylase inhibitor, in the treatment of gastrointestinal (GI) cancer in a phase I clinical trial

(2012) Toshihiko Doi et al.   International Journal of Clinical Oncology

High Passage MIN6 Cells Have Impaired Insulin Secretion with Impaired Glucose and Lipid Oxidation

(2012) Kim Cheng et al.   PLoS One

Specific Control of Pancreatic Endocrine β- and δ-Cell Mass by Class IIa Histone Deacetylases HDAC4, HDAC5, and HDAC9

(2011) Olivia Lenoir et al.   DIABETES

Insulin and Glucagon Regulate Pancreatic α-Cell Proliferation

(2011) Zhuo Liu et al.   PLoS One

Fasting and High-Fat Diet Alter Histone Deacetylase Expression in the Medial Hypothalamus

(2011) Hiromasa Funato et al.   PLoS One

Effect of intrauterine undernutrition during late gestation on pancreatic β cell mass

(2010) Tae Inoue et al.   BIOMEDICAL RESEARCH-TOKYO

Increased ribosomal biogenesis induces pancreatic β cell failure in mice model of type 2 diabetes

(2009) Shun-ichiro Asahara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SirT1 Inhibition Reduces IGF-I/IRS-2/Ras/ERK1/2 Signaling and Protects Neurons

(2008) Ying Li et al.   Cell Metabolism

 -Cell Dysfunction in Subjects With Impaired Glucose Tolerance and Early Type 2 Diabetes: Comparison of Surrogate Markers With First-Phase Insulin Secretion From an Intravenous Glucose Tolerance Test

(2008) A. Festa et al.   DIABETES

Biphasic Response of Pancreatic  -Cell Mass to Ablation of Tuberous Sclerosis Complex 2 in Mice

(2008) Y. Shigeyama et al.   MOLECULAR AND CELLULAR BIOLOGY