Purification of family B G protein-coupled receptors using nanodiscs: Application to human glucagon-like peptide-1 receptor

Design of Next-Generation G Protein–Coupled Receptor Drugs: Linking Novel Pharmacology and In Vivo Animal Models

(2016) Sophie J. Bradley et al.   Annual Review of Pharmacology and Toxicology

Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors

(2016) Li-Hua Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive Allosteric Modulation of the Glucagon-like Peptide-1 Receptor by Diverse Electrophiles

(2016) Ana B. Bueno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanodiscs for structural and functional studies of membrane proteins

(2016) Ilia G Denisov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nanodiscs for structural and functional studies of membrane proteins

(2016) Ilia G Denisov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Triblock peptide–linker–lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors

(2015) Yuting Liu et al.   CHEMICAL COMMUNICATIONS

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics

(2015) Minyoung Park et al.   CHEMISTRY & BIOLOGY

Emerging Approaches to GPCR Ligand Screening for Drug Discovery

(2015) Punita Kumari et al.   TRENDS IN MOLECULAR MEDICINE

Multiple Factors Related to the Secretion of Glucagon-Like Peptide-1

(2015) XingChun Wang et al.   International Journal of Endocrinology

Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors

(2015) Kelly J. Culhane et al.   Frontiers in Pharmacology

Bioorthogonal Fluorescent Labeling of Functional G-Protein-Coupled Receptors

(2014) He Tian et al.   CHEMBIOCHEM

Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid

(2014) Louise Valentin-Hansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetics of Thermal Activation of an Ultraviolet Cone Pigment

(2014) Victoria Mooney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Multisite Unnatural Amino Acid Incorporation in Mammalian Cells via Optimized Pyrrolysyl tRNA Synthetase/tRNA Expression and Engineered eRF1

(2014) Wolfgang H. Schmied et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The GIP Receptor Displays Higher Basal Activity than the GLP-1 Receptor but Does Not Recruit GRK2 or Arrestin3 Effectively

(2014) Suleiman Al-Sabah et al.   PLoS One

Site-Specific Epitope Tagging of G Protein-Coupled Receptors by Bioorthogonal Modification of a Genetically Encoded Unnatural Amino Acid

(2013) Saranga Naganathan et al.   BIOCHEMISTRY

Structure of class B GPCR corticotropin-releasing factor receptor 1

(2013) Kaspar Hollenstein et al.   NATURE

Structure of the human glucagon class B G-protein-coupled receptor

(2013) Fai Yiu Siu et al.   NATURE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Identification of GPCR-Interacting Cytosolic Proteins Using HDL Particles and Mass Spectrometry-Based Proteomic Approach

(2013) Ka Young Chung et al.   PLoS One

Insights into the structure of class B GPCRs

(2013) Kaspar Hollenstein et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Therapeutic Effect of Exendin-4, a Long-Acting Analogue of Glucagon-Like Peptide-1 Receptor Agonist, on Nerve Regeneration after the Crush Nerve Injury

(2013) Koji Yamamoto et al.   Biomed Research International

Calcium-Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs

(2012) Nivedita Mitra et al.   ACS Chemical Biology

Structure and mechanism for recognition of peptide hormones by Class B G-protein-coupled receptors

(2012) Kuntal Pal et al.   ACTA PHARMACOLOGICA SINICA

Correction factors for membrane protein molecular weight readouts on sodium dodecyl sulfate–polyacrylamide gel electrophoresis

(2012) Arianna Rath et al.   ANALYTICAL BIOCHEMISTRY

Secretin family (Class B) G protein-coupled receptors - from molecular to clinical perspectives

(2012) David R Poyner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Physiology and Emerging Biochemistry of the Glucagon-Like Peptide-1 Receptor

(2012) Francis S. Willard et al.   Experimental Diabetes Research

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

(2012) K. G. Harikumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Molecule Force Spectroscopy from Nanodiscs: An Assay to Quantify Folding, Stability, and Interactions of Native Membrane Proteins

(2011) Michael Zocher et al.   ACS Nano

Rhodopsin in Nanodiscs Has Native Membrane-like Photointermediates

(2011) Hisao Tsukamoto et al.   BIOCHEMISTRY

The role of the lipid matrix for structure and function of the GPCR rhodopsin

(2011) Olivier Soubias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Artificial membrane-like environments for in vitro studies of purified G-protein coupled receptors

(2011) Eugene Serebryany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The structure and function of the glucagon-like peptide-1 receptor and its ligands

(2011) Dan Donnelly   BRITISH JOURNAL OF PHARMACOLOGY

Defining CYP3A4 Structural Responses to Substrate Binding. Raman Spectroscopic Studies of a Nanodisc-Incorporated Mammalian Cytochrome P450

(2011) Piotr J. Mak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

The Significance of G Protein-Coupled Receptor Crystallography for Drug Discovery

(2011) J. A. Salon et al.   PHARMACOLOGICAL REVIEWS

Structure and function analyses of the purified GPCR human vomeronasal type 1 receptor 1

(2011) Karolina Corin et al.   Scientific Reports

Recombinant Expression, in Vitro Refolding, and Biophysical Characterization of the Human Glucagon-like Peptide-1 Receptor

(2010) Kathrin Schröder-Tittmann et al.   BIOCHEMISTRY

The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4

(2010) RJ Mann et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glucagonlike Peptide-1 Receptor: An Example of Translational Research in Insulinomas: A Review

(2010) Emanuel Christ et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding

(2010) Timothy H. Bayburt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G protein-coupled receptors: novel targets for drug discovery in cancer

(2010) Rosamaria Lappano et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Specific Transmembrane Residues and Ligand-Induced Interface Changes Involved In Homo-Dimer Formation of a Yeast G Protein-Coupled Receptor

(2009) Heejung Kim et al.   BIOCHEMISTRY

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G-protein-coupled receptors, cholesterol and palmitoylation: facts about fats

(2009) Bice Chini et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Integral Membrane Proteins in Nanodiscs Can Be Studied by Solution NMR Spectroscopy

(2009) Julian M. Glück et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-Level Production, Solubilization and Purification of Synthetic Human GPCR Chemokine Receptors CCR5, CCR3, CXCR4 and CX3CR1

(2009) Hui Ren et al.   PLoS One

GLP-1 receptor signaling: effects on pancreatic β-cell proliferation and survival

(2008) J. Buteau   DIABETES & METABOLISM

GLP-1: physiological effects and potential therapeutic applications

(2008) Kasper Aaboe et al.   DIABETES OBESITY & METABOLISM

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Incorporation of Functional Rhodopsin into Nanoscale Apolipoprotein Bound Bilayer (NABB) Particles

(2008) Sourabh Banerjee et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY