Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance

Direct Measurements of Oxygen Gradients in Spheroid Culture System Using Electron Parametric Resonance Oximetry

(2016) Laura M. Langan et al.   PLoS One

A primary fish gill cell culture model to assess pharmaceutical uptake and efflux: Evidence for passive and facilitated transport

(2015) Lucy C. Stott et al.   AQUATIC TOXICOLOGY

Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures

(2015) Chibuzor Uchea et al.   Toxicology Research

Measured and Modeled Toxicokinetics in Cultured Fish Cells and Application to In Vitro - In Vivo Toxicity Extrapolation

(2014) Julita Stadnicka-Michalak et al.   PLoS One

The rainbow trout genome provides novel insights into evolution after whole-genome duplication in vertebrates

(2014) Camille Berthelot et al.   Nature Communications

The Read-Across Hypothesis and Environmental Risk Assessment of Pharmaceuticals

(2013) Mariann Rand-Weaver et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions

(2013) Kristin A. Connors et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment

(2013) Stefan Scholz et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations

(2013) T. Brodin et al.   SCIENCE

Towards a more representative in vitro method for fish ecotoxicology: morphological and biochemical characterisation of three-dimensional spheroidal hepatocytes

(2012) Matthew G. Baron et al.   ECOTOXICOLOGY

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

(2012) Julita Stadnicka et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Use of the bioaccumulation factor to screen chemicals for bioaccumulation potential

(2012) Jed Costanza et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

In vitromodels of xenobiotic metabolism in trout for use in environmental bioaccumulation studies

(2012) Chibuzor Uchea et al.   XENOBIOTICA

BDDCS Applied to Over 900 Drugs

(2011) Leslie Z. Benet et al.   AAPS Journal

In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol

(2011) Abigail E. Bartram et al.   ENVIRONMENTAL TOXICOLOGY

Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout

(2011) Marja Lahti et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Comparing laboratory and field measured bioaccumulation endpoints

(2011) Lawrence P Burkhard et al.   Integrated Environmental Assessment and Management

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

The influence of gill and liver metabolism on the predicted bioconcentration of three pharmaceuticals in fish

(2010) C.F. Gomez et al.   CHEMOSPHERE

Cross-species comparison of fluoxetine metabolism with fish liver microsomes

(2010) Emily M. Smith et al.   CHEMOSPHERE

Pharmaceuticals in the aquatic environment: A critical review of the evidence for health effects in fish

(2010) Jenna Corcoran et al.   CRITICAL REVIEWS IN TOXICOLOGY

Uptake and Biological Effects of Environmentally Relevant Concentrations of the Nonsteroidal Anti-inflammatory Pharmaceutical Diclofenac in Rainbow Trout (Oncorhynchus mykiss)

(2010) Alvine C. Mehinto et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Metabolites of the Aquatic Pollutant Diclofenac in Fish Bile

(2010) Jenny-Maria Kallio et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry

(2009) Stewart F. Owen et al.   AQUATIC TOXICOLOGY

OCCURRENCE OF PHARMACEUTICALS AND PERSONAL CARE PRODUCTS IN FISH: RESULTS OF A NATIONAL PILOT STUDY IN THE UNITED STATES

(2009) Alejandro J. Ramirez et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments

(2008) Lina Gunnarsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

ESTIMATING METABOLIC BIOTRANSFORMATION RATES IN FISH FROM LABORATORY DATA

(2008) Jon A. Arnot et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

THE STATE OF IN VITRO SCIENCE FOR USE IN BIOACCUMULATION ASSESSMENTS FOR FISH

(2008) Anne V. Weisbrod et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates

(2007) Christina E. Cowan-Ellsberry et al.   CHEMOSPHERE