Comparative pharmaceutical metabolism by rainbow trout (Oncorhynchus mykiss) liver S9 fractions

Dilute Concentrations of a Psychiatric Drug Alter Behavior of Fish from Natural Populations

(2013) T. Brodin et al.   SCIENCE

Pharmaceuticals and Personal Care Products in the Environment: What Are the Big Questions?

(2012) Alistair B.A. Boxall et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Human Therapeutic Plasma Levels of the Selective Serotonin Reuptake Inhibitor (SSRI) Sertraline Decrease Serotonin Reuptake Transporter Binding and Shelter-Seeking Behavior in Adult Male Fathead Minnows

(2012) Theodore W. Valenti et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Occurrence of Pharmaceuticals and Personal Care Products in German Fish Tissue: A National Study

(2012) Bikram Subedi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Evaluation of an isotope dilution liquid chromatography tandem mass spectrometry method for pharmaceuticals in fish

(2012) B. Du et al.   JOURNAL OF CHROMATOGRAPHY A

Ibuprofen Metabolism in the Liver and Gill of Rainbow Trout, Oncorhynchus mykiss

(2011) C. F. Gomez et al.   BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Uptake from water, biotransformation, and biliary excretion of pharmaceuticals by rainbow trout

(2011) Marja Lahti et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Toward an integrated human clearance prediction strategy that minimizes animal use

(2011) Kevin Beaumont et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16α-carbonitrile, rifampicin, and β-naphthoflavone

(2010) Emily M. Smith et al.   AQUATIC TOXICOLOGY

Identification and developmental expression of the full complement of Cytochrome P450 genes in Zebrafish

(2010) Jared V Goldstone et al.   BMC GENOMICS

The influence of gill and liver metabolism on the predicted bioconcentration of three pharmaceuticals in fish

(2010) C.F. Gomez et al.   CHEMOSPHERE

Cross-species comparison of fluoxetine metabolism with fish liver microsomes

(2010) Emily M. Smith et al.   CHEMOSPHERE

Cryopreserved Hepatocytes from Rainbow Trout (Oncorhynchus mykiss): A Validation Study to Support Their Application in Bioaccumulation Assessment

(2010) Robert T. Mingoia et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Therapeutic Levels of Levonorgestrel Detected in Blood Plasma of Fish: Results from Screening Rainbow Trout Exposed to Treated Sewage Effluents

(2010) Jerker Fick et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Uptake and Biological Effects of Environmentally Relevant Concentrations of the Nonsteroidal Anti-inflammatory Pharmaceutical Diclofenac in Rainbow Trout (Oncorhynchus mykiss)

(2010) Alvine C. Mehinto et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Use of intrinsic clearance for prediction of human hepatic clearance

(2010) Piyun Chao et al.   Expert Opinion on Drug Metabolism & Toxicology

Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

(2010) A.-K. Sohlenius-Sternbeck et al.   XENOBIOTICA

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae

(2010) W. Alderton et al.   XENOBIOTICA

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

(2009) Jonathon N. Bauman et al.   CHEMICAL RESEARCH IN TOXICOLOGY

PHARMACEUTICALS AND PERSONAL CARE PRODUCTS: RESEARCH NEEDS FOR THE NEXT DECADE

(2009) Bryan W. Brooks et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

OCCURRENCE OF PHARMACEUTICALS AND PERSONAL CARE PRODUCTS IN FISH: RESULTS OF A NATIONAL PILOT STUDY IN THE UNITED STATES

(2009) Alejandro J. Ramirez et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Kinetics of hepatic phase I and II biotransformation reactions in eight finfish species

(2009) Jaime Fernando González et al.   MARINE ENVIRONMENTAL RESEARCH

Leveraging mammalian pharmaceutical toxicology and pharmacology data to predict chronic fish responses to pharmaceuticals

(2009) Jason P. Berninger et al.   TOXICOLOGY LETTERS

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

(2008) R. Scott Obach et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Evolutionary Conservation of Human Drug Targets in Organisms used for Environmental Risk Assessments

(2008) Lina Gunnarsson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

LIVER MICROSOMES AND S9 FROM RAINBOW TROUT (ONCORHYNCHUS MYKISS): COMPARISON OF BASAL-LEVEL ENZYME ACTIVITIES WITH RAT AND DETERMINATION OF XENOBIOTIC INTRINSIC CLEARANCE IN SUPPORT OF BIOACCUMULATION ASSESSMENT

(2008) Xing Han et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Approach for extrapolating in vitro metabolism data to refine bioconcentration factor estimates

(2007) Christina E. Cowan-Ellsberry et al.   CHEMOSPHERE