Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells

Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment

(2016) Elisa ten Hacken et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor microenvironment (TME)-driven immune suppression in B cell malignancy

(2016) Nicole S. Nicholas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Phenotype and immune function of lymph node and peripheral blood CLL cells are linked to transendothelial migration

(2016) M. Pasikowska et al.   BLOOD

Recent advances in therapy of chronic lymphocytic leukaemia

(2016) David J. M. Routledge et al.   BRITISH JOURNAL OF HAEMATOLOGY

Caffeine toxicity in forensic practice: possible effects and under-appreciated sources

(2016) Ian F. Musgrave et al.   Forensic Science Medicine and Pathology

Mechanisms of tumor escape in the context of the T-cell-inflamed and the non-T-cell-inflamed tumor microenvironment

(2016) Stefani Spranger   INTERNATIONAL IMMUNOLOGY

Breaking Free of Control: How Conventional T Cells Overcome Regulatory T Cell Suppression

(2016) Emily R. Mercadante et al.   Frontiers in Immunology

Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia

(2016) Audrey Mohr et al.   OncoImmunology

PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia

(2015) F. McClanahan et al.   BLOOD

Perturbation of the normal immune system in patients with CLL

(2015) F. Forconi et al.   BLOOD

Prediction of plasma caffeine concentrations in young adolescents following ingestion of caffeinated energy drinks: a Monte Carlo simulation

(2015) Jung Woo Lee et al.   EUROPEAN JOURNAL OF PEDIATRICS

Profound blockade of T cell activation requires concomitant inhibition of different class I PI3K isoforms

(2015) Belén Blanco et al.   IMMUNOLOGIC RESEARCH

Efficacy of phosphatidylinositol-3 kinase inhibitors with diverse isoform selectivity profiles for inhibiting the survival of chronic lymphocytic leukemia cells

(2015) Elisa Göckeritz et al.   INTERNATIONAL JOURNAL OF CANCER

Expression of Functional Sphingosine-1 Phosphate Receptor-1 Is Reduced by B Cell Receptor Signaling and Increased by Inhibition of PI3 Kinase δ but Not SYK or BTK in Chronic Lymphocytic Leukemia Cells

(2015) Kathleen J. Till et al.   JOURNAL OF IMMUNOLOGY

Selectivity is species-dependent: Characterization of standard agonists and antagonists at human, rat, and mouse adenosine receptors

(2015) Mohamad Wessam Alnouri et al.   Purinergic Signalling

CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs

(2014) R. Jitschin et al.   BLOOD

Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110 , for relapsed/refractory chronic lymphocytic leukemia

(2014) J. R. Brown et al.   BLOOD

Immunoregulatory activity of adenosine and its role in human cancer progression

(2014) Sylvia Muller-Haegele et al.   Expert Review of Clinical Immunology

The passive–aggressive relationship between CLL-B cells and T cell immunity

(2014) Joanne E. Davis et al.   LEUKEMIA RESEARCH

Chronic lymphocytic leukaemia cells become both activated and immunosuppressive following interaction with CD3 and CD28 stimulated PBMC

(2014) B.D. Hock et al.   LEUKEMIA RESEARCH

Adenosine production by human B cells and B cell-mediated suppression of activated T cells

(2013) Z. Saze et al.   BLOOD

CMV-specific CD8+ T-cell function is not impaired in chronic lymphocytic leukemia

(2013) G. D. te Raa et al.   BLOOD

Chronic lymphocytic leukemia cells induce defective LFA-1-directed T-cell motility by altering Rho GTPase signaling that is reversible with lenalidomide

(2013) A. G. Ramsay et al.   BLOOD

MicroRNA Regulation of T-Lymphocyte Immunity: Modulation of Molecular Networks Responsible for T-Cell Activation, Differentiation, and Development

(2013) Katie Podshivalova et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia

(2013) D. Brusa et al.   HAEMATOLOGICA

Soluble CD80 Restores T Cell Activation and Overcomes Tumor Cell Programmed Death Ligand 1-Mediated Immune Suppression

(2013) S. T. Haile et al.   JOURNAL OF IMMUNOLOGY

The role ofATMmutations and 11q deletions in disease progression in chronic lymphocytic leukemia

(2013) Tatjana Stankovic et al.   LEUKEMIA & LYMPHOMA

The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies

(2013) Jan A. Burger et al.   SEMINARS IN CANCER BIOLOGY

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes

(2013) Alberto L Horenstein et al.   OncoImmunology

T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production

(2012) J. C. Riches et al.   BLOOD

Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer

(2012) A. G. Ramsay et al.   BLOOD

Lymph node-induced immune tolerance in chronic lymphocytic leukaemia: a role for caveolin-1

(2012) Christine E. Gilling et al.   BRITISH JOURNAL OF HAEMATOLOGY

Effect of activated human polymorphonuclear leucocytes on T lymphocyte proliferation and viability

(2012) Barry D. Hock et al.   IMMUNOLOGY

Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function

(2012) D J DiLillo et al.   LEUKEMIA

A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

(2011) D. Bagnara et al.   BLOOD

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

(2011) S. Serra et al.   BLOOD

The phosphoinositide 3'-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia

(2011) J. Hoellenriegel et al.   BLOOD

Human T cells induce their own regulation through activation of B cells

(2011) Sébastien Lemoine et al.   JOURNAL OF AUTOIMMUNITY

Stat3 Phosphorylation Mediates Resistance of Primary Human T Cells to Regulatory T Cell Suppression

(2011) W. A. Goodman et al.   JOURNAL OF IMMUNOLOGY

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

IL-10 produced by activated human B cells regulates CD4+ T-cell activation in vitro

(2010) Jean-David Bouaziz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Akt is activated in chronic lymphocytic leukemia cells and delivers a pro-survival signal: the therapeutic potential of Akt inhibition

(2009) J. Zhuang et al.   HAEMATOLOGICA

Cell Cycle Progression following Naive T Cell Activation Is Independent of Jak3/Common  -Chain Cytokine Signals

(2009) M. Shi et al.   JOURNAL OF IMMUNOLOGY

Induction of CD4+ T-cell anergy and apoptosis by activated human B cells

(2008) T. Tretter et al.   BLOOD

CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment

(2008) P. E. M. Patten et al.   BLOOD