Article
Pediatrics
Kendrick Lee, Steven R. Laviolette, Daniel B. Hardy
Summary: The study found that exposure to Δ9-THC during pregnancy leads to fetal growth restriction, resulting in smaller hearts relative to body weight at birth, with postnatal catch-up growth but concurrent cardiac remodelling and impaired cardiac function.
PEDIATRIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Ana G. Cristancho, Natalia Tulina, Amy G. Brown, Lauren Anton, Guillermo Barila, Michal A. Elovitz
Summary: Sex-specific differences in behavior have been observed in children exposed to prenatal inflammation, with males showing increased anxiety and females experiencing decreased movement. The age of the individual also plays a role, with these behaviors manifesting differently in neonatal, juvenile, and adult animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Miguel Angel Brieno-Enriquez, Mariela Faykoo-Martinez, Meagan Goben, Jennifer K. Grenier, Ashley McGrath, Alexandra M. Prado, Jacob Sinopoli, Kate Wagner, Patrick T. Walsh, Samia H. Lopa, Diana J. Laird, Paula E. Cohen, Michael D. Wilson, Melissa M. Holmes, Ned J. Place
Summary: Female naked mole rats have a long reproductive lifespan with no significant decline in fertility. The study found that these rats have a large ovarian reserve and undergo postnatal oogenesis. The presence of germ cells and pluripotency markers suggest a unique strategy of maintaining a small population of germ cells that can expand upon reproductive activation.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Emilia Carbone, Valeria Buzzelli, Antonia Manduca, Stefano Leone, Alessandro Rava, Viviana Trezza
Summary: Several studies have shown that maternal immune activation (MIA) during certain gestational periods may increase the risk of offspring developing autism and other neurodevelopmental disorders. In this study, rats were exposed to Lipopolysaccharide to mimic MIA, and the offspring were tested for behavioral deficits and inflammatory markers. The results demonstrate that MIA has a negative impact on neurobehavioral development, leading to deficits in communication, social interaction, cognition, and altered inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Junxiong Ma, Jun Liu, Yu Chen, Hailong Yu, Liangbi Xiang
Summary: The study showed the therapeutic potential of myricetin in the management of diabetic peripheral neuropathy (DPN), suggesting it can improve impaired neural functions and reduce the generation of harmful molecules such as advanced glycation end-products (AGEs) and reactive oxygen species (ROS).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Developmental Biology
Toshiyuki Ohtsuka, Ryoichiro Kageyama
Summary: Hes1 overexpression expands the pool of embryonic NSCs, prolongs the generation of later-born neurons, and leads to the expansion of NSC reservoir in the postnatal and adult brain.
Article
Toxicology
Kazumi Takashima, Kota Nakajima, Saori Shimizu, Ryota Ojiro, Qian Tang, Hiromu Okano, Yasunori Takahashi, Shunsuke Ozawa, Meilan Jin, Tomoya Yoshinari, Toshinori Yoshida, Yoshiko Sugita-Konishi, Makoto Shibutani
Summary: Maternal oral exposure to sterigmatocystin affects hippocampal neurogenesis in offspring by inducing DNA double-strand breaks and oxidative DNA damage, leading to neurogenesis suppression. Various signaling pathways and mechanisms are involved in either promoting or inhibiting neurogenesis.
TOXICOLOGY LETTERS
(2021)
Article
Neurosciences
Charlotte Gustorff, Till Scheuer, Thomas Schmitz, Christoph Buehrer, Stefanie Endesfelder
Summary: GABA and its receptors play important roles in brain development during fetal and postnatal stages. Inhibitors of GABA receptors affect neurogenesis in newborn rats, with GABA(B) receptor blockade decreasing the expression of transcription factors and neurotrophins. Overall, GABAergic signaling, particularly through the GABA(B) receptor, is crucial for hippocampal neurogenesis during rapid brain growth and postnatal brain development.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Environmental Sciences
Ruike Wang, Zuntao Wu, Lin Bai, Rundong Liu, Yue Ba, Huizhen Zhang, Xuemin Cheng, Guoyu Zhou, Hui Huang
Summary: The study confirmed the protective effects of resveratrol against hippocampal neurogenesis impairments induced by lead exposure in male rats, and demonstrated that resveratrol can alleviate cognitive damage and promote neurogenesis through regulation of the SIRT1 pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Neurosciences
Dimitrinka Atanasova, Nikolai Lazarov, Dimo S. Stoyanov, Radoslav H. Spassov, Anton B. Tonchev, Jana Tchekalarova
Summary: Agomelatine has anti-inflammatory and antidepressant effects, which can restore abnormal neuroglia activity in the model and partially restore suppressed neurogenesis.
Article
Medicine, Research & Experimental
Hyeongi Kim, Javeria Zaheer, Eui-Ju Choi, Jin Su Kim
Summary: This study found that PS exposure has malignant effects on the stomach, inducing drug resistance and promoting tumor development and growth. It was discovered that ASGR2 expression plays a role in enhancing cancer hallmarks upon PS exposure. These findings provide new insights into the association between MP exposure and gastric cancer.
Article
Nutrition & Dietetics
Jessica A. Baker, Kristen R. Breit, Tamara S. Bodnar, Joanne Weinberg, Jennifer D. Thomas
Summary: Prenatal alcohol exposure can disrupt the development of the immune system, but choline supplementation can mitigate these effects. The study found that early choline supplementation can reduce the impact of alcohol exposure on hippocampal inflammation and improve hippocampal function.
Article
Cell Biology
Ji Yan, Yan Liu, Fangda Zheng, Dan Lv, Di Jin
Summary: This study investigated whether environmental enrichment was beneficial to ischemic stroke in aged rats. The results showed that environmental enrichment promoted neurogenesis, suppressed apoptosis, and improved motor function recovery in aged rats after stroke.
Article
Pharmacology & Pharmacy
Nafsika Poulia, Foteini Delis, Charalampos Brakatselos, Alexia Polissidis, Yassemi Koutmani, Nikolaos Kokras, Christina Dalla, Panagiotis K. Politis, Katerina Antoniou
Summary: Adolescent low-dose THC exposure negatively impacts psychomotor profile, dopaminergic neurotransmission, compensatory cannabinoid receptor response, cognition-related neurobiological, and behavioral functions.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Wen Wen, Xingrui Gong, Hoiyin Cheung, Yanyan Yang, Meihua Cai, Jijian Zheng, Xiaoping Tong, Mazhong Zhang
Summary: Early life exposure to noxious stimulus and painful experiences can lead to cognitive deficits and abnormal pain sensitivity. Dexmedetomidine (DEX) has demonstrated neuroprotective effects by inhibiting microglial activation and pro-inflammatory cytokine expression, attenuating spinal inflammation and hyperalgesia induced by LPS. The findings suggest that DEX may serve as a protective agent in infection-induced hyperalgesia in neonates and preterm infants.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Lir-Wan Fan, Abhay Bhatt, Lu-Tai Tien, Baoying Zheng, Kimberly L. Simpson, Rick C. S. Lin, Zhengwei Cai, Praveen Kumar, Yi Pang
JOURNAL OF NEUROCHEMISTRY
(2015)
Article
Developmental Biology
Zhengwei Cai, Lir-Wan Fan, Asuka Kaizaki, Lu-Tai Tien, Tangeng Ma, Yi Pang, Shuying Lin, Rick C. S. Lin, Kimberly L. Simpson
DEVELOPMENTAL NEUROSCIENCE
(2013)
Article
Immunology
Asuka Kaizaki, Lu-Tai Tien, Yi Pang, Zhengwei Cai, Sachiko Tanaka, Satoshi Numazawa, Abhay J. Bhatt, Lir-Wan Fan
JOURNAL OF NEUROINFLAMMATION
(2013)
Review
Cell Biology
Abhay Bhatt, Lir-Wan Fan, Yi Pang
NEURAL REGENERATION RESEARCH
(2014)
Article
Neurosciences
Z. Cai, L. -W. Fan, S. Lin, Y. Pang, P. G. Rhodes
Article
Neurosciences
L-W. Fan, A. Kaizaki, L. -T. Tien, Y. Pang, S. Tanaka, S. Numazawa, A. J. Bhatt, Z. Cai
Article
Neurosciences
K. -C. Wang, L. -W. Fan, A. Kaizaki, Y. Pang, Z. Cai, L. -T. Tien
Article
Pediatrics
Leigh R. Campbell, Yi Pang, Norma B. Ojeda, Baoying Zheng, Philip G. Rhodes, Barbara T. Alexander
PEDIATRIC RESEARCH
(2012)
Article
Pediatrics
Yi Pang, Lir-Wan Fan, Baoying Zheng, Leigh R. Campbell, Zhengwei Cai, Philip G. Rhodes
PEDIATRIC RESEARCH
(2012)
Article
Multidisciplinary Sciences
Kimberly L. Simpson, Kristin J. Weaver, Etienne de Villers-Sidani, Jordan Y. -F. Lu, Zhengwei Cai, Yi Pang, Federico Rodriguez-Porcel, Ian A. Paul, Michael Merzenich, Rick C. S. Lin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Pharmacology & Pharmacy
Lu-Tai Tien, Asuka Kaizaki, Yi Pang, Zhengwei Cai, Abhay L. Bhatt, Lir-Wan Fan
Article
Behavioral Sciences
Yi Pang, Baoying Zheng, Simpson L. Kimberly, Zhengwei Cai, Philip G. Rhodes, Rick C. S. Lin
BRAIN AND BEHAVIOR
(2012)
Article
Behavioral Sciences
Yi Pang, Lir-Wan Fan, Lu-Tai Tien, XueMei Dai, Baoying Zheng, Zhengwei Cai, Rick C. S. Lin, Abhay Bhatt
BRAIN AND BEHAVIOR
(2013)
Article
Pediatrics
Marco Loayza, Shuying Lin, Kathleen Carter, Norma Ojeda, Lir-Wan Fan, Sumana Ramarao, Abhay Bhatt, Yi Pang
Summary: This study investigated how maternal immune activation (MIA) affects microglial phenotypes and abnormal neurogenesis in offspring. The results revealed that MIA alters microglial phenotypes and neural development, shedding light on the neurobiological mechanisms of autism spectrum disorder (ASD).
PEDIATRIC RESEARCH
(2023)