Maternal immune activation alters fetal and neonatal microglia phenotype and disrupts neurogenesis in mice

Mid-pregnancy maternal immune activation increases Pax6-positive and Tbr2-positive neural progenitor cells and causes integrated stress response in the fetal brain in a mouse model of maternal viral infection

(2021) Tsuyoshi Tsukada et al.   IBRO Neuroscience Reports

CD36-mediated uptake of myelin debris by macrophages and microglia reduces neuroinflammation

(2020) Elien Grajchen et al.   Journal of Neuroinflammation

Maternal Immune Activation Alters Fetal Brain Development and Enhances Proliferation of Neural Precursor Cells in Rats

(2020) Kelly J. Baines et al.   Frontiers in Immunology

Sex-dependent behavioral deficits and neuropathology in a maternal immune activation model of autism

(2019) Obelia Haida et al.   Translational Psychiatry

The fetal origins of mental illness

(2019) Benjamin J.S. al-Haddad et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Maternal and early postnatal immune activation produce sex-specific effects on autism-like behaviors and neuroimmune function in mice

(2019) William A. Carlezon et al.   Scientific Reports

Biglycan regulates neuroinflammation by promoting M1 microglial activation in early brain injury after experimental subarachnoid hemorrhage

(2019) Yuke Xie et al.   JOURNAL OF NEUROCHEMISTRY

Controversies and prospects about microglia in maternal immune activation models for neurodevelopmental disorders

(2018) Silke Smolders et al.   BRAIN BEHAVIOR AND IMMUNITY

A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer’s models

(2018) Altan Rentsendorj et al.   BRAIN BEHAVIOR AND IMMUNITY

Intrauterine inflammation reduces postnatal neurogenesis in the hippocampal subgranular zone and leads to accumulation of hilar ectopic granule cells

(2018) Michael S. Hester et al.   BRAIN RESEARCH

Maternal IL-17A in autism

(2018) Helen Wong et al.   EXPERIMENTAL NEUROLOGY

Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation

(2018) Despina Kokona et al.   Journal of Neuroinflammation

Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

(2018) Lara Bergdolt et al.   PROGRESS IN NEUROBIOLOGY

Microglia are continuously activated in the circumventricular organs of mouse brain

(2017) Shohei Takagi et al.   JOURNAL OF NEUROIMMUNOLOGY

Acute in utero exposure to lipopolysaccharide induces inflammation in the pre- and postnatal brain and alters the glial cytoarchitecture in the developing amygdala

(2017) Elaine O’Loughlin et al.   Journal of Neuroinflammation

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

Fundamental Elements in Autism: From Neurogenesis and Neurite Growth to Synaptic Plasticity

(2017) James Gilbert et al.   Frontiers in Cellular Neuroscience

Expression of cerebral serotonin related to anxiety-like behaviors in C57BL/6 offspring induced by repeated subcutaneous prenatal exposure to low-dose lipopolysaccharide

(2017) Pei-Tan Hsueh et al.   PLoS One

Microglia in the TBI brain: The good, the bad, and the dysregulated

(2016) David J. Loane et al.   EXPERIMENTAL NEUROLOGY

Maternal immune activation leads to selective functional deficits in offspring parvalbumin interneurons

(2016) S Canetta et al.   MOLECULAR PSYCHIATRY

Altered proliferation and networks in neural cells derived from idiopathic autistic individuals

(2016) M C Marchetto et al.   MOLECULAR PSYCHIATRY

Intranasal insulin protects against substantia nigra dopaminergic neuronal loss and alleviates motor deficits induced by 6-OHDA in rats

(2016) Y. Pang et al.   NEUROSCIENCE

Neocortical neurogenesis and the etiology of autism spectrum disorder

(2016) Alan Packer   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Maternal immune activation: Implications for neuropsychiatric disorders

(2016) M. L. Estes et al.   SCIENCE

The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring

(2016) G. B. Choi et al.   SCIENCE

Early Postnatal Lipopolysaccharide Exposure Leads to Enhanced Neurogenesis and Impaired Communicative Functions in Rats

(2016) Yi Pang et al.   PLoS One

A Distinct Population of Microglia Supports Adult Neurogenesis in the Subventricular Zone

(2015) A. L. Ribeiro Xavier et al.   JOURNAL OF NEUROSCIENCE

Immune mediators in the brain and peripheral tissues in autism spectrum disorder

(2015) Myka L. Estes et al.   NATURE REVIEWS NEUROSCIENCE

Prenatal administration of lipopolysaccharide induces sex-dependent changes in glutamic acid decarboxylase and parvalbumin in the adult rat brain

(2015) A. Basta-Kaim et al.   NEUROSCIENCE

Early prenatal exposure to LPS results in anxiety- and depression-related behaviors in adulthood

(2015) A.M. Depino   NEUROSCIENCE

Prenatal LPS-exposure – a neurodevelopmental rat model of schizophrenia – differentially affects cognitive functions, myelination and parvalbumin expression in male and female offspring

(2015) Lena Wischhof et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Single and combined effects of prenatal immune activation and peripubertal stress on parvalbumin and reelin expression in the hippocampal formation

(2014) Sandra Giovanoli et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Topographic Mapping between Basal Forebrain Cholinergic Neurons and the Medial Prefrontal Cortex in Mice

(2014) Bernard Bloem et al.   JOURNAL OF NEUROSCIENCE

Maternal immune activation and abnormal brain development across CNS disorders

(2014) Irene Knuesel et al.   Nature Reviews Neurology

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Patches of Disorganization in the Neocortex of Children with Autism

(2014) Rich Stoner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism

(2014) Simone Gupta et al.   Nature Communications

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

(2014) Janel E. Le Belle et al.   Stem Cell Reports

Prenatal lipopolysaccharide exposure increases depression-like behaviors and reduces hippocampal neurogenesis in adult rats

(2013) Yu-Lung Lin et al.   BEHAVIOURAL BRAIN RESEARCH

Selective Upregulation of Scavenger Receptors in and Around Demyelinating Areas in Multiple Sclerosis

(2013) Debbie A.E. Hendrickx et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

(2013) C. L. Cunningham et al.   JOURNAL OF NEUROSCIENCE

Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development

(2012) Paula A. Garay et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Prenatal exposure to lipopolysaccharide results in neurodevelopmental damage that is ameliorated by zinc in mice

(2011) Joanne S.C. Chua et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuron Number and Size in Prefrontal Cortex of Children With Autism

(2011) Eric Courchesne et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy

(2011) Louise Harvey et al.   NEUROPHARMACOLOGY

Effects of prenatal immune activation on hippocampal neurogenesis in the rat

(2009) Ke Cui et al.   SCHIZOPHRENIA RESEARCH

Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke

(2008) Pär Thored et al.   GLIA