Semi-synthesis of a HGF/SF kringle one (K1) domain scaffold generates a potent in vivo MET receptor agonist

An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides

(2014) Kyle E Landgraf et al.   Nature Chemical Biology

A novel PEG-based solid support enables the synthesis of >50 amino-acid peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate

(2014) Emmanuelle Boll et al.   Chemical Science

Total synthesis of biotinylated N domain of human hepatocyte growth factor

(2013) Laurent Raibaut et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Wound healing potential of a dimeric InlB variant analyzed by in vitro experiments on re-epithelialization of human skin models

(2013) F. Kolditz et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments

(2013) Laurent Raibaut et al.   Chemical Science

Multivalency as a Chemical Organization and Action Principle

(2012) Carlo Fasting et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential native peptide ligation strategies for total chemical protein synthesis

(2012) Laurent Raibaut et al.   CHEMICAL SOCIETY REVIEWS

Targeting the HGF/Met signaling pathway in cancer therapy

(2012) Fabiola Cecchi et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hepatocyte growth factor stimulated angiogenesis without inflammation: Differential actions between hepatocyte growth factor, vascular endothelial growth factor and basic fibroblast growth factor

(2012) Toshihiro Kaga et al.   VASCULAR PHARMACOLOGY

A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

(2011) Nathalie Ollivier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Engineered Variants of Hepatocyte Growth Factor/Scatter Factor Promote Proliferation of Primary Human Hepatocytes and in Rodent Liver

(2011) Jacob Ross et al.   GASTROENTEROLOGY

Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists

(2011) Douglas S. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

The Met receptor tyrosine kinase and basal breast cancer

(2010) Marisa G. Ponzo et al.   CELL CYCLE

MET signalling: principles and functions in development, organ regeneration and cancer

(2010) Livio Trusolino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Bis(2-sulfanylethyl)amino Native Peptide Ligation

(2010) Nathalie Ollivier et al.   ORGANIC LETTERS

Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis

(2010) R. Sinha Roy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for agonism and antagonism of hepatocyte growth factor

(2010) W. D. Tolbert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Nanoengineering Approach for Investigation and Regulation of Protein Immobilization

(2008) Yih Horng Tan et al.   ACS Nano

Studying protein structure and function using semisynthesis

(2008) Tom W. Muir   BIOPOLYMERS

c-Met gene amplification is associated with advanced stage colorectal cancer and liver metastases

(2008) Zhao-Shi Zeng et al.   CANCER LETTERS

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Molecular mechanism of apoptosis and gene expressions in human lymphoma U937 cells treated with anisomycin

(2008) Takeshi Hori et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Magic-Factor 1, a Partial Agonist of Met, Induces Muscle Hypertrophy by Protecting Myogenic Progenitors from Apoptosis

(2008) Marco Cassano et al.   PLoS One