A novel PEG-based solid support enables the synthesis of >50 amino-acid peptide thioesters and the total synthesis of a functional SUMO-1 peptide conjugate

Modifying the Vicinity of the Isopeptide Bond To Reveal Differential Behavior of Ubiquitin Chains with Interacting Proteins: Organic Chemistry Applied to Synthetic Proteins

(2013) Najat Haj-Yahya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Convergent Chemical Synthesis of Histone H2B Protein for the Site-Specific Ubiquitination at Lys34

(2013) Peter Siman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical assembly of N-glycoproteins: a refined toolbox to address a ubiquitous posttranslational modification

(2013) Carlo Unverzagt et al.   CHEMICAL SOCIETY REVIEWS

SUMOylated RanGAP1 prepared by click chemistry

(2013) Nadine D. van Treel et al.   JOURNAL OF PEPTIDE SCIENCE

Tidbits for the synthesis ofbis(2-sulfanylethyl)amido (SEA) polystyrene resin, SEA peptides and peptide thioesters

(2013) Nathalie Ollivier et al.   JOURNAL OF PEPTIDE SCIENCE

Bis(2-sulfanylethyl)amido Peptides Enable Native Chemical Ligation at Proline and Minimize Deletion Side-Product Formation

(2013) Laurent Raibaut et al.   ORGANIC LETTERS

Protein chemical synthesis by serine and threonine ligation

(2013) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly efficient solid phase synthesis of large polypeptides by iterative ligations of bis(2-sulfanylethyl)amido (SEA) peptide segments

(2013) Laurent Raibaut et al.   Chemical Science

Nonenzymatic Polymerization of Ubiquitin: Single-Step Synthesis and Isolation of Discrete Ubiquitin Oligomers

(2012) Vivian H. Trang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemistry and Biology of the Ubiquitin Signal

(2012) Liat Spasser et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential α-Ketoacid-Hydroxylamine (KAHA) Ligations: Synthesis of C-Terminal Variants of the Modifier Protein UFM1

(2012) Ayodele O. Ogunkoya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sequential native peptide ligation strategies for total chemical protein synthesis

(2012) Laurent Raibaut et al.   CHEMICAL SOCIETY REVIEWS

Forging Isopeptide Bonds Using Thiol–Ene Chemistry: Site-Specific Coupling of Ubiquitin Molecules for Studying the Activity of Isopeptidases

(2012) Ellen M. Valkevich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125

(2012) Mirva Hejjaoui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Chemical Synthesis of a 304 Amino Acid K48-Linked Tetraubiquitin Protein

(2011) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A One-Pot Three-Segment Ligation Strategy for Protein Chemical Synthesis

(2011) Nathalie Ollivier et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expanded Click Conjugation of Recombinant Proteins with Ubiquitin-Like Modifiers Reveals Altered Substrate Preference of SUMO2-Modified Ubc9

(2011) Stefanie Sommer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click synthesis of ubiquitin dimer analogs to interrogate linkage-specific UBA domain binding

(2011) Nadine D. Weikart et al.   CHEMICAL COMMUNICATIONS

Synthesis of Peptide Alkylthioesters Using the IntramolecularN,S-Acyl Shift Properties of Bis(2-sulfanylethyl)amido Peptides

(2011) Julien Dheur et al.   JOURNAL OF ORGANIC CHEMISTRY

Histone H2B ubiquitylation disrupts local and higher-order chromatin compaction

(2011) Beat Fierz et al.   Nature Chemical Biology

Synthesis of Thiazolidine Thioester Peptides and Acceleration of Native Chemical Ligation

(2011) Julien Dheur et al.   ORGANIC LETTERS

Total Chemical Synthesis of Di-ubiquitin Chains

(2010) K. S. Ajish Kumar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin

(2010) Farid El Oualid et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

9-Fluorenylmethoxycarbonyl-Based Solid-Phase Synthesis of Peptide α-Thioesters

(2010) Franziska Mende et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine

(2010) Renliang Yang et al.   CHEMICAL COMMUNICATIONS

Chemical Approaches for Studying Histone Modifications

(2010) Champak Chatterjee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonhydrolyzable Ubiquitin−Isopeptide Isosteres as Deubiquitinating Enzyme Probes.

(2010) Anitha Shanmugham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Defined Ubiquitin Dimers

(2010) Silvia Eger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation

(2010) Champak Chatterjee et al.   Nature Chemical Biology

N-Methylcysteine-mediated total chemical synthesis of ubiquitin thioester

(2010) Lesly A. Erlich et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bis(2-sulfanylethyl)amino Native Peptide Ligation

(2010) Nathalie Ollivier et al.   ORGANIC LETTERS

PeptidylN,N-Bis(2-mercaptoethyl)-amides as Thioester Precursors for Native Chemical Ligation†

(2010) Wen Hou et al.   ORGANIC LETTERS

Structure–Activity Analysis of Semisynthetic Nucleosomes: Mechanistic Insights into the Stimulation of Dot1L by Ubiquitylated Histone H2B

(2009) Robert K. McGinty et al.   ACS Chemical Biology

Dual Native Chemical Ligation at Lysine

(2009) Renliang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

Expressed Protein Ligation (EPL) in the Study of Signal Transduction, Ion Conduction, And Chromatin Biology

(2008) Robert R. Flavell et al.   ACCOUNTS OF CHEMICAL RESEARCH

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation

(2008) Robert K. McGinty et al.   NATURE