An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor

(2015) Chung-Hang Leung et al.   CHEMICAL COMMUNICATIONS

Albumin binding and ligand-exchange processes of the Ru(iii) anticancer agent NAMI-A and its bis-DMSO analogue determined by ENDOR spectroscopy

(2015) Michael I. Webb et al.   DALTON TRANSACTIONS

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

(2014) Stuart W. J. Ember et al.   ACS Chemical Biology

Antagonizing STAT3 Dimerization with a Rhodium(III) Complex

(2014) Dik-Lung Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting Nucleus DNA with a Cyclometalated Dipyridophenazineruthenium(II) Complex

(2014) Huaiyi Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application

(2014) Robert Trondl et al.   Chemical Science

Enhanced Cytotoxicity through Conjugation of a “Clickable” Luminescent Re(I) Complex to a Cell-Penetrating Lipopeptide

(2014) Anna Leonidova et al.   ACS Medicinal Chemistry Letters

Bioactive Luminescent Transition-Metal Complexes for Biomedical Applications

(2013) Dik-Lung Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy

(2013) M. F. Segura et al.   CANCER RESEARCH

Application of mass spectrometric techniques to delineate the modes-of-action of anticancer metallodrugs

(2013) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

Emerging protein targets for metal-based pharmaceutical agents: An update

(2013) Andreia de Almeida et al.   COORDINATION CHEMISTRY REVIEWS

Regulation of nucleosome dynamics by histone modifications

(2013) Gabriel E Zentner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Enzyme inhibition by metal complexes: concepts, strategies and applications

(2013) Kelly J. Kilpin et al.   Chemical Science

A Metal-Based Inhibitor of Tumor Necrosis Factor-α

(2012) Chung-Hang Leung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On the Biological Properties of Alkynyl Phosphine Gold(I) Complexes

(2012) Andreas Meyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Designing organometallic compounds for catalysis and therapy

(2012) Anna Louisa Noffke et al.   CHEMICAL COMMUNICATIONS

Bioactive cyclometalated phthalimides: design, synthesis and kinase inhibition

(2012) Sebastian Blanck et al.   DALTON TRANSACTIONS

Pyridocarbazole-Rhodium(III) Complexes as Protein Kinase Inhibitors

(2012) Sandra Dieckmann et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Cyclometalated phenylquinoline rhodium complexes as protein kinase inhibitors

(2012) Stefan Mollin et al.   INORGANICA CHIMICA ACTA

Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies

(2012) Orsolya Dömötör et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

P-donor ligand containing ruthenium half-sandwich complexes as protein kinase inhibitors

(2011) Craig Streu et al.   INORGANICA CHIMICA ACTA

Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery

(2011) Chun-wa Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors

(2011) Li Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Nonemissive Iridium(III) Complex That Specifically Lights-Up the Nuclei of Living Cells

(2011) Chunyan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The resurgence of covalent drugs

(2011) Juswinder Singh et al.   NATURE REVIEWS DRUG DISCOVERY

Organometallic Pyridylnaphthalimide Complexes as Protein Kinase Inhibitors

(2011) Sebastian Blanck et al.   ORGANOMETALLICS

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

Structure of anticancer ruthenium half-sandwich complex bound to glycogen synthase kinase 3β

(2010) G. Ekin Atilla-Gokcumen et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

A Ruthenium-Containing Organometallic Compound Reduces Tumor Growth through Induction of the Endoplasmic Reticulum Stress Gene CHOP

(2009) Xiangjun Meng et al.   CANCER RESEARCH

Targeting proteins with metal complexes

(2009) Eric Meggers   CHEMICAL COMMUNICATIONS

Platinum Drug Distribution in Cancer Cells and Tumors

(2009) Alice V. Klein et al.   CHEMICAL REVIEWS

Metal complexes in medicine with a focus on enzyme inhibition

(2009) Chi-Ming Che et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Toward the Development of a Potent and Selective Organoruthenium Mammalian Sterile 20 Kinase Inhibitor

(2009) Ruchi Anand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Brd4 Marks Select Genes on Mitotic Chromatin and Directs Postmitotic Transcription

(2009) Anup Dey et al.   MOLECULAR BIOLOGY OF THE CELL

A Highly Selective Luminescent Switch-On Probe for Histidine/Histidine-Rich Proteins and Its Application in Protein Staining

(2008) Dik-Lung Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

Bromodomain 4 activation predicts breast cancer survival

(2008) N. P. S. Crawford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA