PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo

Short Communication: Immune Activation Is Present in HIV-1-Exposed Seronegative Individuals and Is Independent of Microbial Translocation

(2016) Irma Saulle et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Rectal HSV-2 Infection May Increase Rectal SIV Acquisition Even in the Context of SIVΔnef Vaccination

(2016) Natalia Guerra-Pérez et al.   PLoS One

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

(2016) Jennifer Paijo et al.   PLoS Pathogens

Increased Expression of CD169 on Blood Monocytes and Its Regulation by Virus and CD8 T Cells in Macaque Models of HIV Infection and AIDS

(2015) Woong-Ki Kim et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Genital Inflammation and the Risk of HIV Acquisition in Women

(2015) Lindi Masson et al.   CLINICAL INFECTIOUS DISEASES

Human Anti-CD40 Antibody and Poly IC:LC Adjuvant Combination Induces Potent T Cell Responses in the Lung of Nonhuman Primates

(2015) Elizabeth A. Thompson et al.   JOURNAL OF IMMUNOLOGY

Differential outcome of TRIF-mediated signaling in TLR4 and TLR3 induced DC maturation

(2015) Wei Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic Receptor Melanoma Differentiation–Associated Protein 5 Mediates Preconditioning-Induced Neuroprotection Against Cerebral Ischemic Injury

(2015) Raffaella Gesuete et al.   STROKE

Vaccine adjuvant uses of poly-IC and derivatives

(2014) Karen AO Martins et al.   Expert Review of Vaccines

Live Simian Immunodeficiency Virus Vaccine Correlate of Protection: Local Antibody Production and Concentration on the Path of Virus Entry

(2014) Qingsheng Li et al.   JOURNAL OF IMMUNOLOGY

CD169-Dependent Cell-Associated HIV-1 Transmission: A Driver of Virus Dissemination

(2014) S. Gummuluru et al.   JOURNAL OF INFECTIOUS DISEASES

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

(2014) Siddappa N Byrareddy et al.   NATURE MEDICINE

Sex Hormones Selectively Impact the Endocervical Mucosal Microenvironment: Implications for HIV Transmission

(2014) Diana Goode et al.   PLoS One

Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation

(2014) Austin Pantel et al.   PLOS BIOLOGY

HIV-1 Capture and Transmission by Dendritic Cells: The Role of Viral Glycolipids and the Cellular Receptor Siglec-1

(2014) Nuria Izquierdo-Useros et al.   PLoS Pathogens

The role of dendritic cells in driving genital tract inflammation and HIV transmission risk: Are there opportunities to intervene?

(2013) Muki S Shey et al.   Innate Immunity

Polyinosinic-Polycytidylic Acid Is the Most Effective TLR Adjuvant for SIV Gag Protein-Induced T Cell Responses In Nonhuman Primates

(2013) H. Park et al.   JOURNAL OF IMMUNOLOGY

Pediatric Phase II Trials of Poly-ICLC in the Management of Newly Diagnosed and Recurrent Brain Tumors

(2013) Lisa L.R. Hartman et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

TLR-4 engagement of dendritic cells confers a BST-2/tetherin-mediated restriction of HIV-1 infection to CD4+ T cells across the virological synapse

(2013) Fabien P Blanchet et al.   Retrovirology

Interferon-Inducible Mechanism of Dendritic Cell-Mediated HIV-1 Dissemination Is Dependent on Siglec-1/CD169

(2013) Wendy Blay Puryear et al.   PLoS Pathogens

Characterization of Peripheral and Mucosal Immune Responses In Rhesus Macaques on Long-Term Tenofovir and Emtricitabine Combination Antiretroviral Therapy

(2012) Edith Jasny et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

HIV-1 Capture and Antigen Presentation by Dendritic Cells: Enhanced Viral Capture Does Not Correlate with Better T Cell Activation

(2012) M. T. Rodriguez-Plata et al.   JOURNAL OF IMMUNOLOGY

Lymph node T cell responses predict the efficacy of live attenuated SIV vaccines

(2012) Yoshinori Fukazawa et al.   NATURE MEDICINE

HIV-1 Nef Enhances Dendritic Cell-Mediated Viral Transmission to CD4+ T Cells and Promotes T-Cell Activation

(2012) Corine St. Gelais et al.   PLoS One

A dendrite in every pie

(2012) Elizabeth R. Wonderlich et al.   Virulence

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

(2012) Nuria Izquierdo-Useros et al.   PLOS BIOLOGY

ADCC Develops Over Time during Persistent Infection with Live-Attenuated SIV and Is Associated with Complete Protection against SIVmac251 Challenge

(2012) Michael D. Alpert et al.   PLoS Pathogens

Phase I Study Utilizing a Novel Antigen-Presenting Cell-Targeted Vaccine with Toll-like Receptor Stimulation to Induce Immunity to Self-antigens in Cancer Patients

(2011) M. A. Morse et al.   CLINICAL CANCER RESEARCH

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates

(2011) B. J. Flynn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid dendritic cells in HIV-1 infection

(2011) Nina Derby et al.   Current Opinion in HIV and AIDS

HSV-2 Infection of Dendritic Cells Amplifies a Highly Susceptible HIV-1 Cell Target

(2011) Elena Martinelli et al.   PLoS Pathogens

Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands

(2010) R. Conforti et al.   CANCER RESEARCH

Manipulation of dendritic cell function by viruses

(2010) Anthony L Cunningham et al.   CURRENT OPINION IN MICROBIOLOGY

TLR3 agonists as immunotherapeutic agents

(2010) Christopher F Nicodemus et al.   Immunotherapy

Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms

(2010) Beth K. Thielen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of CD8+ T-Cell Responses Against Novel Glioma–Associated Antigen Peptides and Clinical Activity by Vaccinations With α-Type 1 Polarized Dendritic Cells and Polyinosinic-Polycytidylic Acid Stabilized by Lysine and Carboxymethylcellulose in Patients With Recurrent Malignant Glioma

(2010) Hideho Okada et al.   JOURNAL OF CLINICAL ONCOLOGY

Herpes Simplex Virus Type 2 Enhances HIV-1 Susceptibility by Affecting Langerhans Cell Function

(2010) M. A. W. P. de Jong et al.   JOURNAL OF IMMUNOLOGY

Blocking of  4 7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

(2010) A. A. Ansari et al.   JOURNAL OF IMMUNOLOGY

A Tonsillar PolyICLC/AT-2 SIV Therapeutic Vaccine Maintains Low Viremia Following Antiretroviral Therapy Cessation

(2010) Panagiotis Vagenas et al.   PLoS One

Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in non human primates

(2010) Kavita Tewari et al.   VACCINE

Nef Proteins from Simian Immunodeficiency Viruses Are Tetherin Antagonists

(2009) Fengwen Zhang et al.   Cell Host & Microbe

Antiviral Role of Toll-Like Receptor-3 Agonists Against Seasonal and Avian Influenza Viruses

(2009) J. Wong et al.   CURRENT PHARMACEUTICAL DESIGN

Tonsillar Application of AT-2 SIV Affords Partial Protection Against Rectal Challenge With SIVmac239

(2009) Panagiotis Vagenas et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Dendritic cells require a systemic type I interferon response to mature and induce CD4+Th1 immunity with poly IC as adjuvant

(2009) M. Paula Longhi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibitory TCR Coreceptor PD-1 Is a Sensitive Indicator of Low-Level Replication of SIV and HIV-1

(2009) Nadine C. Salisch et al.   JOURNAL OF IMMUNOLOGY

Not All Polyriboinosinic-polyribocytidylic Acids (Poly I:C) are Equivalent for Inducing Maturation of Dendritic Cells

(2009) Tony Avril et al.   JOURNAL OF IMMUNOTHERAPY

Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques

(2009) Christiane Stahl-Hennig et al.   PLoS Pathogens

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Double-Stranded RNA Analog Poly(I:C) Inhibits Human Immunodeficiency Virus Amplification in Dendritic Cells via Type I Interferon-Mediated Activation of APOBEC3G

(2008) S. Trapp et al.   JOURNAL OF VIROLOGY

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu

(2008) Stuart J. D. Neil et al.   NATURE

Sialoadhesin Expressed on IFN-Induced Monocytes Binds HIV-1 and Enhances Infectivity

(2008) Hans Rempel et al.   PLoS One

Efficacy of Carraguard®-Based Microbicides In Vivo Despite Variable In Vitro Activity

(2008) Stuart G. Turville et al.   PLoS One

The microbial mimic poly IC induces durable and protective CD4+ T cell immunity together with a dendritic cell targeted vaccine

(2008) C. Trumpfheller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA