Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments

Computational Studies Support the Role of the C7-Sibirosamine Sugar of the Pyrrolobenzodiazepine (PBD) Sibiromycin in Transcription Factor Inhibition

(2014) Paul J. M. Jackson et al.   ACS Chemical Biology

A Potent Anti-CD70 Antibody–Drug Conjugate Combining a Dimeric Pyrrolobenzodiazepine Drug with Site-Specific Conjugation Technology

(2013) Scott C. Jeffrey et al.   BIOCONJUGATE CHEMISTRY

SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML

(2013) M. S. Kung Sutherland et al.   BLOOD

GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models

(2013) Khondaker M. Rahman et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Extended Pyrrolobenzodiazepine–Polyamide Conjugate with Selectivity for a DNA Sequence Containing the ICB2 Transcription Factor Binding Site

(2013) Federico Brucoli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolo[2,1-c][1,4]benzodiazepine as a Scaffold for the Design and Synthesis of Anti- Tumour Drugs

(2012) Laura Cipolla et al.   Anti-Cancer Agents in Medicinal Chemistry

Observation of a Single-Stranded DNA/Pyrrolobenzodiazepine Adduct

(2011) Khondaker M. Rahman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers

(2011) Khondaker M. Rahman et al.   NUCLEIC ACIDS RESEARCH

Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy

(2011) Khondaker M. Rahman et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A DC-81-indole conjugate agent suppresses melanoma A375 cell migration partially via interrupting VEGF production and stromal cell-derived factor-1α-mediated signaling

(2011) Ming-Chu Hsieh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Synthesis of DNA-Interactive Pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

(2010) Dyeison Antonow et al.   CHEMICAL REVIEWS

DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents

(2010) Khondaker M. Rahman et al.   ACS Medicinal Chemistry Letters

Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential

(2009) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A phase I trial of SJG-136 (NSC#694501) in advanced solid tumors

(2009) Yelena Y. Janjigian et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Phase I Study of Sequence-Selective Minor Groove DNA Binding Agent SJG-136 in Patients with Advanced Solid Tumors

(2009) D. Hochhauser et al.   CLINICAL CANCER RESEARCH

Fanconi Anemia Proteins, DNA Interstrand Crosslink Repair Pathways, and Cancer Therapy

(2009) Paul Andreassen et al.   CURRENT CANCER DRUG TARGETS

The Pyrrolobenzodiazepine Dimer SJG-136 Forms Sequence-Dependent Intrastrand DNA Cross-Links and Monoalkylated Adducts in Addition to Interstrand Cross-Links

(2009) Khondaker M. Rahman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78

(2008) M. Kotecha et al.   MOLECULAR CANCER THERAPEUTICS

An assay combining high-performance liquid chromatography and mass spectrometry to measure DNA interstrand cross-linking efficiency in oligonucleotides of varying sequences

(2007) Mathangi Narayanaswamy et al.   ANALYTICAL BIOCHEMISTRY