Article
Oncology
Geng-Hang Chen, Zhiwei Liu, Ming-Fang Ji, Ruth M. Pfeiffer, Qi-Hong Huang, Yu-Qiang Lu, Shang-Hang Xie, Chu-Yang Lin, Wen-Jie Chen, Xiao-Xia Chen, Wei Ling, Yu-Ying Fan, Xia Yu, Biao-Hua Wu, Kuang-Rong Wei, Hui-Lian Rao, Xiang Guo, Ming-Huang Hong, Jun Ma, Qing Liu, Allan Hildesheim, Su-Mei Cao
Summary: In a NPC screening trial in southern China, researchers validated the discriminatory power of an EBV-based risk score, showing high sensitivity and positive predictive value at different levels of specificity. Combining the EBV score with population incidence data allowed for calculation of absolute NPC risk. Adding nonviral risk factors did not improve the prediction model.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Jacob A. Miller, Malaya K. Sahoo, Fumiko Yamamoto, ChunHong Huang, Hannah Wang, James L. Zehnder, Quynh-Thu Le, Benjamin A. Pinsky
Summary: By detecting EBV BALF2 gene polymorphisms in plasma, screening for EBV-associated nasopharyngeal carcinoma can be improved by reducing false positives and repeated testing. There is a significant association between BALF2 haplotypes and NPC, which can be leveraged to develop screening programs that improve screening accuracy.
Article
Virology
Raja Pramanik, Shalabh Arora, Preity Sharma, Ahitagni Biswas, Baibaswata Nayak, Alok Thakar, Atul Sharma, Sampa Ghose
Summary: Nasopharyngeal carcinoma is not endemic in India but shows higher incidences in its North-Eastern regions. Detecting NPC early is challenging, and assessing plasma Epstein-Barr virus DNA load can help monitor disease status, treatment response, and future relapse risk in nonendemic NPC patients.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li-Jen Liao, Wan-Lun Hsu, Chi-Ju Chen, Yen-Ling Chiu
Summary: Nasopharyngeal carcinoma is endemic in southern Asia and this article describes the molecular abnormalities in NPC and potential molecular mechanisms for future therapy. It provides an up-to-date review on the molecular pathways of NPC, improving our understanding of the disease and highlighting areas for further research.
Article
Medicine, General & Internal
Yudi Xiong, Mengting Yuan, Zhigang Liu, Jing Huang, Jianping Bi, Guoliang Pi, Ying Li, Yanping Li, Hanping He, Vivek Verma, Suqing Tian, Guang Han
Summary: This multicenter study examined the clinical characteristics of EBV-negative patients in the Chinese population and compared their long-term outcomes with EBV-positive patients. The study found that most EBV-negative patients were diagnosed in advanced stages and were more associated with the keratinizing subtype. Compared to EBV-negative patients, EBV-positive patients were more likely to experience local recurrence, but there was no significant difference in mortality during the follow-up period. Additionally, EBV-positive NPC patients seemed to have better survival compared to EBV-negative NPC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Ramon Yarza, Mateo Bover, Maria Teresa Agullo-Ortuno, Lara Carmen Iglesias-Docampo
Summary: Nasopharyngeal carcinoma (NPC) is a molecularly paradigmatic tumor with complex environmental and host dependent factors, where Epstein Barr Virus (EBV) plays a key role in malignant transformation. The dysregulation of proteasome signaling is central in NPC pathogenesis and could be a potential therapeutic target. Studies have shown the efficacy of immunotherapy in NPC, with novel strategies aiming to reverse immune resistance and favor tumor recognition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Review
Oncology
Rina Jiromaru, Takashi Nakagawa, Ryuji Yasumatsu
Summary: Nasopharyngeal carcinoma (NPC) has shown improved treatment outcomes in recent years, but advanced stages still carry a poor prognosis. Chemoradiotherapy is the main treatment option, along with platinum-based chemotherapy. Immunotherapy, especially immune checkpoint inhibitors, is being explored as a potential treatment for recurrent or metastatic NPC. Future trends in NPC treatment include risk classification based on plasma EBV-DNA levels and personalized therapy selection.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yong-Qiao He, Ting Zhou, Da-Wei Yang, Yi-Jing Jia, Lei-Lei Yuan, Wen-Li Zhang, Tong-Min Wang, Ying Liao, Wen-Qiong Xue, Jiang-Bo Zhang, Xiao-Hui Zheng, Xi-Zhao Li, Pei-Fen Zhang, Shao-Dan Zhang, Ye-Zhu Hu, Fang Wang, William C. Cho, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: Oral Epstein-Barr virus (EBV) DNA load is a non-invasive predictor that can be used for prognostic evaluation and risk stratification in patients with nasopharyngeal carcinoma (NPC).
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Oncology
James C. H. Chow, Anne W. M. Lee, Charlene H. L. Wong, Wai Tong Ng, Zhiwei Liu, Joshua K. Tay, Kwok Seng Loh, Pia Pace-Asciak, Oded Cohen, June Corry, Juan Pablo Rodrigo, Raymond K. Y. Tsang, Fernando Lopez, Nabil F. Saba, Remco de Bree, Alfio Ferlito
Summary: In endemic areas of nasopharyngeal carcinoma (NPC), individuals with a positive family history (FH+) and positive Epstein-Barr virus (EBV) status have a higher risk of developing NPC. Familial screening using EBV serology may aid in the early detection of NPC.
Article
Virology
Kena Lin, Zhiwen Zeng, Xueqi Li, Wenjie Chen, Dongfeng Lin, Shanghang Xie, Zhicong Wu, Mengmeng Li, Sumei Cao, Jinlin Du
Summary: This study investigated the association between hypertension and Epstein-Barr virus (EBV) reactivation. It found that hypertension increased the risk of EBV reactivation, while beta-blockers and angiotensin converting enzyme inhibitors (ACEIs) were associated with a reduced risk of EBV reactivation.
Review
Cell Biology
Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai
Summary: This review provides updated understanding of the roles of epigenetic factors in regulating EBV latent gene expression and promoting NPC progression. The crosstalk between epigenetic mechanisms and immune evasion in NPC is explored, along with the potential roles of DNMT and HDAC inhibitors in reversing immune suppression and augmenting antitumour immunity. Furthermore, the advantages of combining epigenetic therapy and immune checkpoint inhibitor to reverse immune resistance and improve clinical outcomes are highlighted.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Xiandong Lin, Steven Wang, Keyu Lin, Jingfeng Zong, Qianlan Zheng, Ying Su, Tao Huang
Summary: This study investigated the roles of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression network and performing differential expression analysis. The Epstein-Barr virus (EBV) infection was found to be an important risk factor for NPC, with potential pathological differences between EBV+ and EBV- subtypes. The study identified differentially expressed coding and non-coding RNAs across different comparison groups, helping to elucidate genetic and epigenetic changes central to NPC progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Microbiology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy associated with Epstein-Barr virus (EBV). Despite global EBV infection, NPC incidences are higher in certain ethnic groups and endemic regions. Research has revealed the molecular mechanisms of NPC pathogenesis due to EBV infection and environmental/genetic factors. EBV-associated biomarkers can be used for mass population screening and EBV products may act as therapeutic targets. This review discusses the role of EBV in NPC and efforts to utilize EBV-associated molecules as biomarkers and therapeutic targets.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Oncology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma microenvironment is a complex niche with important clinical value, which can serve as a rich field for the discovery of potential predictive or diagnostic biomarkers and the development of therapeutic strategies. Studying this environment can provide a better understanding of tumor biology mechanisms and guide clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guofei Feng, Liting Qin, Zhipeng Liao, Xiling Xiao, Bo Li, Wanmeng Cui, Libin Liang, Yingxi Mo, Guangwu Huang, Ping Li, Xiaoying Zhou, Zhe Zhang, Xue Xiao
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Microbiology
Justine W. Debelius, Tingting Huang, Yonglin Cai, Alexander Ploner, Donal Barrett, Xiaoying Zhou, Xue Xiao, Yancheng Li, Jian Liao, Yuming Zheng, Guangwu Huang, Hans-Olov Adami, Yi Zeng, Zhe Zhang, Weimin Ye
Article
Oncology
Tingting Huang, Justine W. Debelius, Alexander Ploner, Xiling Xiao, Tingting Zhang, Kai Hu, Zhe Zhang, Rensheng Wang, Weimin Ye
Summary: This study investigated the changes in the nasopharyngeal microbiome among patients with nasopharyngeal carcinoma during radiation therapy and found stable temporal changes. It provided preliminary evidence of an association between the microbiome changes and short-term clinical outcomes.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Oncology
Ruimei Feng, Ellen T. Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Yu Zhang, Jing-Ping Yun, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Tingting Huang, Longde Lin, Ingemar Ernberg, Guangwu Huang, Yi-Xin Zeng, Hans-Olov Adami, Weimin Ye
Summary: The study found no significant association between alcohol intake and nasopharyngeal carcinoma risk, while tea drinking may moderately reduce the risk. There is a significant nonlinear dose-response relationship between tea intake and NPC risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Oncology
Li Jiang, Bo Li, Yong Zhang, Shanshan Ma, Chang Liu, Feifei Liang, Zhuxin Wei, Tingting Huang, Rensheng Wang
Summary: This study investigated the impact of treatment on the vaginal microbiome in patients receiving pelvic IMRT with concurrent cisplatin-based chemotherapy. Significant differences were found in the vaginal microbial composition between patients and healthy controls, and certain microbial abundances increased over time, suggesting a potential role of the vaginal microbiome in cervical cancer treatment outcomes. Further research into these effects could lead to new therapeutic strategies to enhance radiochemotherapy efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Tingting Huang, Alexander Ploner, Ellen T. Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qihong Huang, Shanghang Xie, Sumei Cao, Weihua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Ingemar Ernberg, Guangwu Huang, Yi Zeng, Yixin Zeng, Hans-Olov Adami, Weimin Ye
Summary: Plant-based and animal-based dietary factors are significantly associated with the risk of nasopharyngeal carcinoma (NPC), while high intakes of preserved foods are linked to an increased risk of NPC. The study suggests that dietary factors in adulthood may be more stable and robust predictors of NPC risk compared to those in adolescence.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Oncology
Yufeng Chen, Ellen T. Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Wei-Hua Jia, Yuming Zheng, Yancheng Li, Longde Lin, Ingemar Ernberg, Dongming Wang, Weihong Chen, Ruimei Feng, Guangwu Huang, Yi-Xin Zeng, Hans-Olov Adami, Weimin Ye
Summary: Occupational exposures to dusts, chemical vapors, exhausts/smokes, or acids/alkalis are associated with an excess risk of nasopharyngeal carcinoma (NPC) in high-incidence areas like southern China. The risk of NPC appears to increase linearly with duration of exposure, suggesting a causal relationship between occupational exposures and NPC development.
Article
Rheumatology
Sibo Zhu, Kelin Xu, Yanfeng Jiang, Chengkai Zhu, Chen Suo, Mei Cui, Yingzhe Wang, Ziyu Yuan, Jiangli Xue, Jiucun Wang, Tiejun Zhang, Genming Zhao, Weimin Ye, Tingting Huang, Ming Lu, Weizhong Tian, Li Jin, Xingdong Chen
Summary: This study investigates the role of gut microbiota in vascular physiology in a subclinical elderly population. The results show that gut microbes significantly contribute to the pathogenesis of carotid atherosclerosis, and certain lifestyle factors can impact the composition of gut microbiota, leading to changes in vascular health.
Article
Environmental Sciences
Yufeng Chen, Ellen T. Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Wei-Hua Jia, Yuming Zheng, Yancheng Li, Longde Lin, Ingemar Ernberg, Hongwei Zhao, Ruimei Feng, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Hans-Olov Adami, Weimin Ye
Summary: This study found that living in cottages or boats, using wood, coal, or kerosene as cooking fuel, drinking well water, river water, or spring/pond/stream water, and living in houses with smaller-sized windows were associated with an increased risk of NPC.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Jiangwei Sun, Tingting Huang, Justine W. Debelius, Fang Fang
Summary: ALS is a rare and incurable neurodegenerative disease characterized by a loss of motor neurons in the brain and spinal cord. Contributions from outside the central nervous system to the etiology of ALS, including the gut microbiome, are increasingly recognized. Results from animal studies on altered gut microbiome composition in ALS are relatively consistent, while findings from human studies are largely inconclusive.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Tian Liang, Fang Liu, Lifeng Ma, Zhiying Zhang, Lijun Liu, Tingting Huang, Jing Li, Wenxue Dong, Han Zhang, Yansong Li, Yaqiong Jiang, Weimin Ye, Su Bai, Longli Kang
Summary: This study investigated the impact of migration on the intestinal microbiota of Tibetan women who migrated from Tibet to Xianyang. The results showed that the diversity of microbiota remained stable after migration, with specific microbial markers identified at different time points. Functional prediction analysis also revealed no significant changes in gene pathways post-migration. The findings suggest that the intestinal microbiota of Tibetan women is relatively stable despite changes in environment and diet due to migration.
Article
Cardiac & Cardiovascular Systems
Zhijian Yang, Erin Macdonald-Dunlop, Jiantao Chen, Ranran Zhai, Ting Li, Anne Richmond, Lucija Klaric, Nicola Pirastu, Zheng Ning, Chenqing Zheng, Yipeng Wang, Tingting Huang, Yazhou He, Huiming Guo, Kejun Ying, Stefan Gustafsson, Bram Prins, Anna Ramisch, Emmanouil T. Dermitzakis, Grace Png, Niclas Eriksson, Jeffrey Haessler, Xiaowei Hu, Daniela Zanetti, Thibaud Boutin, Shih-Jen Hwang, Eleanor Wheeler, Maik Pietzner, Laura M. Raffield, Anette Kalnapenkis, James E. Peters, Ana Vinuela, Arthur Gilly, Solve Elmstahl, George Dedoussis, John R. Petrie, Ozren Polasek, Lasse Folkersen, Yan Chen, Chen Yao, Urmo Vosa, Erola Pairo-Castineira, Sara Clohisey, Andrew D. Bretherick, Konrad Rawlik, Tonu Esko, Stefan Enroth, Asa Johansson, Ulf Gyllensten, Claudia Langenberg, Daniel Levy, Caroline Hayward, Themistocles L. Assimes, Charles Kooperberg, Ani W. Manichaikul, Agneta Siegbahn, Lars Wallentin, Lars Lind, Eleftheria Zeggini, Jochen M. Schwenk, Adam S. Butterworth, Karl Michaelsson, Yudi Pawitan, Peter K. Joshi, J. Kenneth Baillie, Anders Malarstig, Alexander P. Reiner, James F. Wilson, Xia Shen
Summary: In this study, genetic correlations between plasma ACE2 levels and cardiovascular disease, COVID-19, and other related diseases were identified. Mendelian randomization analysis showed a causal effect of elevated ACE2 levels on COVID-19 severity, hospitalization, and infection. The study also revealed that ACE2 regulatory variants were enriched for DNA methylation sites in blood immune cells.
Article
Immunology
Yun Du, Ruimei Feng, Ellen T. Chang, Justine W. Debelius, Li Yin, Miao Xu, Tingting Huang, Xiaoying Zhou, Xue Xiao, Yancheng Li, Jian Liao, Yuming Zheng, Guangwu Huang, Hans-Olov Adami, Zhe Zhang, Yonglin Cai, Weimin Ye
Summary: The oral microbiome may have an impact on the prognosis of nasopharyngeal carcinoma (NPC). Lower within-community diversity is associated with higher mortality, while certain measures of between-community diversity are related to mortality.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Oncology
Yaxuan Huang, Yunyun Lan, Zhe Zhang, Xue Xiao, Tingting Huang
Summary: Oropharyngeal squamous cell carcinoma (OPSCC) is a rare malignancy that has seen an increasing incidence in developed countries. Human papillomavirus (HPV) infection has become a major factor in the development of OPSCC. While radiotherapy and surgery are recommended as first-line treatments, chemotherapy is used for advanced cases. Immunotherapy is gaining attention in the treatment of advanced head and neck squamous cell carcinoma (HNSCC). Research on checkpoint inhibitors has shown benefit for metastatic HNSCC patients. The impact of HPV infection on immunotherapeutic efficacy in HNSCC patients is still debated.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yufeng Chen, Wanxin Li, Ellen T. Chang, Justine W. Debelius, Lokeshwaran Manoharan, Yuming Zheng, Yancheng Li, Guangwu Huang, Hans-Olov Adami, Rob Knight, Yonglin Cai, Zhe Zhang, Weimin Ye
Summary: Dysbiosis of the oral mycobiome, characterized by a loss of fungal community diversity and overgrowth of several fungal organisms, is associated with a significantly increased risk of nasopharyngeal carcinoma (NPC).
