Review
Oncology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma microenvironment is a complex niche with important clinical value, which can serve as a rich field for the discovery of potential predictive or diagnostic biomarkers and the development of therapeutic strategies. Studying this environment can provide a better understanding of tumor biology mechanisms and guide clinical practice.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Huageng Huang, Yuyi Yao, Xinyi Deng, Zongyao Huang, Yungchang Chen, Zhao Wang, Huangming Hong, He Huang, Tongyu Lin
Summary: Nasopharyngeal carcinoma (NPC) is highly associated with Epstein-Barr virus (EBV) infection and conventional salvage treatments for advanced NPC have limited efficacy. Immunotherapy has emerged as a promising treatment modality for recurrent and metastatic NPC.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Li-Jen Liao, Wan-Lun Hsu, Chi-Ju Chen, Yen-Ling Chiu
Summary: Nasopharyngeal carcinoma is endemic in southern Asia and this article describes the molecular abnormalities in NPC and potential molecular mechanisms for future therapy. It provides an up-to-date review on the molecular pathways of NPC, improving our understanding of the disease and highlighting areas for further research.
Article
Oncology
Kelly J. Yu, Wan-Lun Hsu, Chun-Ju Chiang, Tseng-Cheng Chen, Zhiwei Liu, Pei-Jen Lou, Scott Diehl, Alisa M. Goldstein, Chien-Jen Chen, Cheng-Ping Wang, Allan Hildesheim
Summary: This study reassessed familial aggregation of cancer in high-risk Taiwanese multiplex families with NPC cases and found evidence of NPC coaggregation within families, but not a broader familial syndrome involving NPC and other tumors. The study also observed elevated rates of secondary cancers among NPC cases, mostly head and neck and hematopoietic cancers, suggesting radiation treatment effects on subsequent cancer risk.
Review
Oncology
Rina Jiromaru, Takashi Nakagawa, Ryuji Yasumatsu
Summary: Nasopharyngeal carcinoma (NPC) has shown improved treatment outcomes in recent years, but advanced stages still carry a poor prognosis. Chemoradiotherapy is the main treatment option, along with platinum-based chemotherapy. Immunotherapy, especially immune checkpoint inhibitors, is being explored as a potential treatment for recurrent or metastatic NPC. Future trends in NPC treatment include risk classification based on plasma EBV-DNA levels and personalized therapy selection.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Y-J. Hu, T. -Z. Lu, H. Zhang, M. Fang, B. -J. Chen, Q. -J. Guo, S. -J. Lin, P. Feng, Y. Wang, T. -C. Jiang, X. -C. Gong, J. -J. Pan, J. -G. Li, Y. -F. Xia
Summary: Palliative chemotherapy combined with anti-PD-1 mAbs followed by LRRT improved the progression-free survival (PFS) in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC), especially for patients with early Epstein-Barr virus DNA (EBV DNA) clearance.
Review
Cell Biology
Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai
Summary: This review provides updated understanding of the roles of epigenetic factors in regulating EBV latent gene expression and promoting NPC progression. The crosstalk between epigenetic mechanisms and immune evasion in NPC is explored, along with the potential roles of DNMT and HDAC inhibitors in reversing immune suppression and augmenting antitumour immunity. Furthermore, the advantages of combining epigenetic therapy and immune checkpoint inhibitor to reverse immune resistance and improve clinical outcomes are highlighted.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Cell Biology
Xiandong Lin, Steven Wang, Keyu Lin, Jingfeng Zong, Qianlan Zheng, Ying Su, Tao Huang
Summary: This study investigated the roles of microRNAs and circular RNAs in Nasopharyngeal Carcinoma (NPC) by constructing a circRNA-miRNA-mRNA co-expression network and performing differential expression analysis. The Epstein-Barr virus (EBV) infection was found to be an important risk factor for NPC, with potential pathological differences between EBV+ and EBV- subtypes. The study identified differentially expressed coding and non-coding RNAs across different comparison groups, helping to elucidate genetic and epigenetic changes central to NPC progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Microbiology
Zhi Yi Su, Pui Yan Siak, Chee-Onn Leong, Shiau-Chuen Cheah
Summary: Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy associated with Epstein-Barr virus (EBV). Despite global EBV infection, NPC incidences are higher in certain ethnic groups and endemic regions. Research has revealed the molecular mechanisms of NPC pathogenesis due to EBV infection and environmental/genetic factors. EBV-associated biomarkers can be used for mass population screening and EBV products may act as therapeutic targets. This review discusses the role of EBV in NPC and efforts to utilize EBV-associated molecules as biomarkers and therapeutic targets.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Oncology
Xiao-Hui Zheng, Chang-Mi Deng, Ting Zhou, Xi-Zhao Li, Cao-Li Tang, Cheng-Tao Jiang, Ying Liao, Tong-Min Wang, Yong-Qiao He, Wei-Hua Jia
Summary: Saliva sampling is a non-invasive method that can be done by individuals themselves. This study used saliva samples to explore the use of EBV methylation as a biomarker in the diagnosis of NPC. The results showed that EBV methylation was significantly increased in NPC patients compared to controls, and detection of specific CpG sites showed good diagnostic performance. The study suggests that non-invasive detection of NPC through saliva sampling could be a promising alternative for future large-scale screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Oncology
Yu-Jing Liang, Qiu-Yan Chen, Jing-Xiao Xu, Xiu-Feng Liu, Jian-Chuan Xia, Li-Ting Liu, Shan-Shan Guo, Bin Song, Pan Wang, Ji-Bin Li, Qing Liu, Hao-Yuan Mo, Ling Guo, Rui Sun, Dong-Hua Luo, Jia He, Yi-Na Liu, Cai-Ping Nie, Lin-Quan Tang, Jiang Li, Hai-Qiang Mai
Summary: The phase I study evaluated the safety and clinical responses of adjuvant autologous TILs after CCRT in NPC patients. No significant difference was observed in the 3-year PFS rate between the CCRT plus TIL infusion group and the CCRT alone group. TIL infusion was safe and the high-grade adverse effects were associated with myelosuppression caused by CCRT.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Yudi Xiong, Mengting Yuan, Zhigang Liu, Jing Huang, Jianping Bi, Guoliang Pi, Ying Li, Yanping Li, Hanping He, Vivek Verma, Suqing Tian, Guang Han
Summary: This multicenter study examined the clinical characteristics of EBV-negative patients in the Chinese population and compared their long-term outcomes with EBV-positive patients. The study found that most EBV-negative patients were diagnosed in advanced stages and were more associated with the keratinizing subtype. Compared to EBV-negative patients, EBV-positive patients were more likely to experience local recurrence, but there was no significant difference in mortality during the follow-up period. Additionally, EBV-positive NPC patients seemed to have better survival compared to EBV-negative NPC patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Virology
Tengteng Ding, Yuanbin Zhang, Zhixuan Ren, Ying Cong, Jingyi Long, Manli Peng, Oluwasijibomi Damola Faleti, Yinggui Yang, Xin Li, Xiaoming Lyu
Summary: This study developed a model using Epstein-Barr virus (EBV)-associated hub genes to predict the prognosis of nasopharyngeal carcinoma (NPC). Through differential expression analysis, regression analysis, and machine learning, 25 genes significantly associated with NPC prognosis were identified, along with six hub genes related to immune infiltration and cell cycle regulation. These genes could be used to predict NPC prognosis, with functions related to tumor proliferation and immune infiltration, making them potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Yaqi Chen, Anqi Cao, Qinkai Li, JunMin Quan
Summary: In this study, DNA aptamers specifically binding to EBV positive NPC cells were developed using the Cell-SELEX procedure, and the EphA2/CD98hc complex was identified as a potential target. The results revealed a potential function of the EphA2 and CD98hc complex in NPCs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Mateo Bover, Ramon Yarza, Lara Iglesias Docampo
CLINICAL LUNG CANCER
(2020)
Article
Oncology
M. Teresa Agullo-Ortuno, Oscar Gomez-Martin, Santiago Ponce, Lara Iglesias, Laura Ojeda, Irene Ferrer, Inmaculada Garcia-Ruiz, Luis Paz-Ares, Virginia Pardo-Marques
CLINICAL LUNG CANCER
(2020)
Article
Oncology
M. Teresa Agullo-Ortuno, Inmaculada Garcia-Ruiz, C. Vanesa Diaz-Garcia, Ana B. Enguita, Virginia Pardo-Marques, Elena Prieto-Garcia, Santiago Ponce, Lara Iglesias, Jon Zugazagoitia, Jose A. Lopez-Martin, Luis Paz-Ares, Juan A. Nunez
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2020)
Letter
Gastroenterology & Hepatology
Santiago de Cossio, Blas Labrador, Ramon Yarza, Laura Corbella, Mario Fernandez-Ruiz
GASTROENTEROLOGIA Y HEPATOLOGIA
(2020)
Article
Oncology
Ramon Yarza, Mateo Bover, Diana Paredes, Flora Lopez-Lopez, Diego Jara-Casas, Alicia Castelo-Loureiro, Javier Baena, Jose Maria Mazarico, Maria Dolores Folgueira, Maria Angeles Melendez-Carmo, Alhena Reyes, Carlos Lumbreras, Luis Paz-Ares, Carmen Diaz-Pedroche, Carlos Gomez-Martin
EUROPEAN JOURNAL OF CANCER
(2020)
Article
Environmental Sciences
Sagrario Gomez-Cantarino, M. Teresa Agullo-Ortuno, Mercedes de Dios-Aguado, M. Idoia Ugarte-Gurrutxaga, Carmen Bouzas-Mosquera
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Biochemistry & Molecular Biology
Elena Prieto-Garcia, C. Vanesa Diaz-Garcia, Alba Agudo-Lopez, Virginia Pardo-Marques, Ines Garcia-Consuegra, Sara Asensio-Pena, Marina Alonso-Riano, Carlos Perez, Carlos Gomez, Jorge Adeva, Luis Paz-Ares, Jose A. Lopez-Martin, M. Teresa Agullo-Ortuno
Summary: Researchers found in an in vitro coculture model that under coculture conditions, fibroblasts were activated, epithelial markers in tumor cells were decreased, and the two types of cells migrated together. Changes in IL-6 levels could potentially affect the invasive and migratory capacities of the cells. Targeting the interaction between tumor cells and the tumor microenvironment could be a novel therapeutic approach for advanced PDAC.
Article
Oncology
Ramon Yarza, Mateo Bover, Mercedes Herrera-Juarez, Macarena Rey-Cardenas, Luis Paz-Ares, Jose A. Lopez-Martin, John Haanen
Summary: TCR-based ACT has shown promising results in treating metastatic cutaneous melanoma, with a notable antitumor activity and survival benefit.
Article
Biochemistry & Molecular Biology
M. Teresa Agullo-Ortuno, Esther Mancebo, Montserrat Grau, Juan Antonio Nunez Sobrino, Luis Paz-Ares, Jose A. Lopez-Martin, Marta Flandez
Summary: Cancer cachexia is a complex syndrome that hampers treatment, decreases quality of life, and affects patient survival. The pathophysiology of cachexia is not fully understood and there are no effective treatments or biomarkers. However, alterations in tryptophan metabolism have been observed in cachectic patients. By studying mouse models of cancer-associated cachexia, researchers found that tryptophan levels were reduced in tumor-bearing mice and cachectic patients. Treatment with a tryptophan degradation inhibitor restored tryptophan levels and improved spleen enlargement and protein oxidation, indicating that targeting the tryptophan metabolism pathway could be a promising approach for modulating inflammation in cancer cachexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ramon Yarza, Mateo Bover, Mercedes Herrera-Juarez, Macarena Rey-Cardenas, Luis Paz-Ares, Jose A. Lopez-Martin, John Haanen
Summary: This study conducted a systematic review and meta-analysis to assess the primary efficacy of TCR-based adoptive cell therapy in cutaneous melanoma. The results showed promising antitumor activity and survival for TCR-T therapy, with a significantly higher benefit for cancer/testis antigen targeting cells.
Article
Oncology
Analia Rodriguez-Garzotto, Lara Iglesias-Docampo, C. Vanesa Diaz-Garcia, Isabel Ruppen, Pilar Ximenez-Embun, Carlos Gomez, J. Luis Rodriguez-Peralto, Javier Ortiz de Frutos, Jose A. Lopez-Martin, Cristina Gravalos, Hernan Cortes-Funes, M. Teresa Agullo-Ortuno
Summary: Based on the results, topical heparin is an effective and safe treatment for clinical manifestations of hand-foot syndrome (HFS) induced by capecitabine. The proteomic analysis indicates that heparin treatment may restore skin homeostasis, thereby contributing to the therapeutic effects.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Mateo Bover, Irene Otero, Ramon Yarza
Summary: Immune checkpoint inhibitors have become a standard of care in oncology, but their use can lead to immune-related adverse events. Clinicians must closely monitor and intervene early to identify and manage these potentially severe complications.
CURRENT PROBLEMS IN CANCER: CASE REPORTS
(2021)
Article
Health Care Sciences & Services
Mercedes de Dios-Aguado, Maria Teresa Agullo-Ortuno, Maria Idoia Ugarte-Gurrutxaga, Benito Yanez-Araque, Brigida Molina-Gallego, Sagrario Gomez-Cantarino
Summary: The study found significant differences between Spanish and foreign pregnant women in terms of living conditions, education levels, and economic independence. Through health education, pregnant women in this region adopted bicultural dietary patterns, maintaining a balance of protein levels in their bodies.