PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer

14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2

(2015) Jia Xu et al.   CANCER CELL

PEAK1, a Novel Kinase Target in the Fight Against Cancer

(2015)   Oncotarget

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Upregulated WAVE3 expression is essential for TGF-β-mediated EMT and metastasis of triple-negative breast cancer cells

(2013) Molly A. Taylor et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor Dissemination: An EMT Affair

(2013) Jean Paul Thiery et al.   CANCER CELL

Involvement of Lyn and the Atypical Kinase SgK269/PEAK1 in a Basal Breast Cancer Signaling Pathway

(2013) D. R. Croucher et al.   CANCER RESEARCH

Src Family Kinases as Novel Therapeutic Targets to Treat Breast Cancer Brain Metastases

(2013) S. Zhang et al.   CANCER RESEARCH

Temporal regulation of EGF signalling networks by the scaffold protein Shc1

(2013) Yong Zheng et al.   NATURE

KRas Induces a Src/PEAK1/ErbB2 Kinase Amplification Loop That Drives Metastatic Growth and Therapy Resistance in Pancreatic Cancer

(2012) J. A. Kelber et al.   CANCER RESEARCH

GSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer

(2012) Tomohiro Miyake et al.   CANCER SCIENCE

TGF-β signaling in development and disease

(2012) Joan Massagué   FEBS LETTERS

Dynamic Phosphorylation of Tyrosine 665 in Pseudopodium-enriched Atypical Kinase 1 (PEAK1) Is Essential for the Regulation of Cell Migration and Focal Adhesion Turnover

(2012) Jeanne M. Bristow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting the TGFβ signalling pathway in disease

(2012) Rosemary J. Akhurst et al.   NATURE REVIEWS DRUG DISCOVERY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptomic landscape of breast cancers through mRNA sequencing

(2012) Jeyanthy Eswaran et al.   Scientific Reports

Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization

(2011) Kuo-Jang Kao et al.   BMC CANCER

Deconstructing the mechanisms and consequences of TGF-β-induced EMT during cancer progression

(2011) Michael K. Wendt et al.   CELL AND TISSUE RESEARCH

SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity

(2011) Lee B. Rivera et al.   JOURNAL OF CELL BIOLOGY

Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-β-mediated cancer cell invasiveness

(2010) Isao Matsuura et al.   BIOCHEMICAL JOURNAL

The repositioning of the anti-fungal agent ciclopirox olamine as a novel therapeutic agent for the treatment of haematologic malignancy

(2010) S. J. Weir et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Towards a knowledge-based Human Protein Atlas

(2010) Mathias Uhlen et al.   NATURE BIOTECHNOLOGY

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression

(2010) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β-induced epithelial to mesenchymal transition

(2009) Jian Xu et al.   CELL RESEARCH

p130Cas Is Required for Mammary Tumor Growth and Transforming Growth Factor-β-mediated Metastasis through Regulation of Smad2/3 Activity

(2009) Michael K. Wendt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

(2008) Sherene Loi et al.   BMC GENOMICS

Grb2 binding to Tyr284 in TβR-II is essential for mammary tumor growth and metastasis stimulated by TGF-β

(2008) Amy J. Galliher-Beckley et al.   CARCINOGENESIS

TGFβ Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4

(2008) David Padua et al.   CELL

TGFβ in Cancer

(2008) Joan Massagué   CELL

Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis

(2008) Jing Yang et al.   DEVELOPMENTAL CELL

Molecular analysis of hormone receptor positive (luminal) breast cancers – What have we learnt?

(2008) Sherene Loi   EUROPEAN JOURNAL OF CANCER

Stromal gene expression predicts clinical outcome in breast cancer

(2008) Greg Finak et al.   NATURE MEDICINE