miR-34 and p53: New Insights into a Complex Functional Relationship

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

(2014) N. Okada et al.   GENES & DEVELOPMENT

miR-34/449 miRNAs are required for motile ciliogenesis by repressing cp110

(2014) Rui Song et al.   NATURE

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2

(2014) Jing Y. Krzeszinski et al.   NATURE

Quantitative Proteomic Analysis of Gene Regulation by miR-34a and miR-34c

(2014) Olivia A. Ebner et al.   PLoS One

Oligoasthenoteratozoospermia and Infertility in Mice Deficient for miR-34b/c and miR-449 Loci

(2014) Stefano Comazzetto et al.   PLoS Genetics

p53 regulates nuclear GSK-3 levels through miR-34-mediated Axin2 suppression in colorectal cancer cells

(2013) Nam Hee Kim et al.   CELL CYCLE

Downregulation of miR-34a in breast tumors is not associated with either p53 mutations or promoter hypermethylation while it correlates with metastasis

(2013) Arash Javeri et al.   MEDICAL ONCOLOGY

The impact of post-transcriptional regulation in the p53 network

(2012) J. A. Freeman et al.   Briefings in Functional Genomics

miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions

(2012) Helge Siemens et al.   CELL CYCLE

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer

(2012) Claudia Piovan et al.   Molecular Oncology

A transcription activator-like effector toolbox for genome engineering

(2012) Neville E Sanjana et al.   Nature Protocols

Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop

(2012) J Zhang et al.   ONCOGENE

MicroRNA-34a Modulates MDM4 Expression via a Target Site in the Open Reading Frame

(2012) Pooja Mandke et al.   PLoS One

Intact p53-Dependent Responses in miR-34–Deficient Mice

(2012) Carla P. Concepcion et al.   PLoS Genetics

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

MicroRNA-449 in cell fate determination

(2011) Muriel Lizé et al.   CELL CYCLE

miR-605joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

(2011) Jiening Xiao et al.   EMBO JOURNAL

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

(2011) Nam Hee Kim et al.   JOURNAL OF CELL BIOLOGY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genome-wide Characterization ofmiR-34aInduced Changes in Protein and mRNA Expression by a Combined Pulsed SILAC and Microarray Analysis

(2011) Markus Kaller et al.   MOLECULAR & CELLULAR PROTEOMICS

Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription

(2011) Feng Zhang et al.   NATURE BIOTECHNOLOGY

miR-34 miRNAs provide a barrier for somatic cell reprogramming

(2011) Yong Jin Choi et al.   NATURE CELL BIOLOGY

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

(2011) Can Liu et al.   NATURE MEDICINE

Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting

(2011) Tomas Cermak et al.   NUCLEIC ACIDS RESEARCH

Capture of MicroRNA–Bound mRNAs Identifies the Tumor Suppressor miR-34a as a Regulator of Growth Factor Signaling

(2011) Ashish Lal et al.   PLoS Genetics

Downregulation of p53-inducible microRNAs 192, 194, and 215 Impairs the p53/MDM2 Autoregulatory Loop in Multiple Myeloma Development

(2010) Flavia Pichiorri et al.   CANCER CELL

Systematic Proteome Analysis Identifies Transcription Factor YY1 as a Direct Target of miR-34a

(2010) Qing-Rong Chen et al.   JOURNAL OF PROTEOME RESEARCH

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Role of miR-34c microRNA in the late steps of spermatogenesis

(2010) F. Bouhallier et al.   RNA

miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53

(2009) F. Navarro et al.   BLOOD

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC

(2009) N R Christoffersen et al.   CELL DEATH AND DIFFERENTIATION

The miR-34 family in cancer and apoptosis

(2009) H Hermeking   CELL DEATH AND DIFFERENTIATION

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Tumor Suppressive Functions of p53

(2009) J. T. Zilfou et al.   Cold Spring Harbor Perspectives in Biology

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest

(2008) Fang Sun et al.   FEBS LETTERS

A Functional Screen Identifies miR-34a as a Candidate Neuroblastoma Tumor Suppressor Gene

(2008) K. A. Cole et al.   MOLECULAR CANCER RESEARCH

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA