Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

The promise of induced pluripotent stem cells in research and therapy

(2012) Daisy A. Robinton et al.   NATURE

Present state and future perspectives of using pluripotent stem cells in toxicology research

(2011) Anna M. Wobus et al.   ARCHIVES OF TOXICOLOGY

Epigenetic Memory and Preferential Lineage-Specific Differentiation in Induced Pluripotent Stem Cells Derived from Human Pancreatic Islet Beta Cells

(2011) Ori Bar-Nur et al.   Cell Stem Cell

Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency

(2011) Frederick Anokye-Danso et al.   Cell Stem Cell

Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs

(2011) Norikatsu Miyoshi et al.   Cell Stem Cell

Inducing iPSCs to Escape the Dish

(2011) Bonnie Barrilleaux et al.   Cell Stem Cell

miRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2

(2011) Nils Pfaff et al.   EMBO REPORTS

Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol

(2011) Yu-Fan Chen et al.   HEPATOLOGY

Rescue of ATP7B function in hepatocyte-like cells from Wilson's disease induced pluripotent stem cells using gene therapy or the chaperone drug curcumin

(2011) Shiqiang Zhang et al.   HUMAN MOLECULAR GENETICS

MicroRNA Cluster 302–367 Enhances Somatic Cell Reprogramming by Accelerating a Mesenchymal-to-Epithelial Transition

(2011) Baojian Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3

(2011) H. K. Bone et al.   JOURNAL OF CELL SCIENCE

Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells

(2011) Kosuke Yusa et al.   NATURE

Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells

(2011) Deepa Subramanyam et al.   NATURE BIOTECHNOLOGY

The business of exploiting induced pluripotent stem cells

(2011) C. Prescott   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Human Embryonic Stem Cell Derived Hepatocyte-Like Cells as a Tool for In Vitro Hazard Assessment of Chemical Carcinogenicity

(2011) Reha Yildirimman et al.   TOXICOLOGICAL SCIENCES

Role of CYP2E1-mediated metabolism in the acute and vestibular toxicities of nineteen nitriles in the mouse

(2011) Sandra Saldaña-Ruíz et al.   TOXICOLOGY LETTERS

From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics

(2011) Bob Wilffert et al.   International Journal of Clinical Pharmacy

Emergency re-admissions to hospital due to adverse drug reactions within 1 year of the index admission

(2010) Emma C. Davies et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Reprogramming of Human Primary Somatic Cells by OCT4 and Chemical Compounds

(2010) Saiyong Zhu et al.   Cell Stem Cell

Lab-Specific Gene Expression Signatures in Pluripotent Stem Cells

(2010) Aaron M. Newman et al.   Cell Stem Cell

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Species extrapolation for the 21st century

(2010) Malin C. Celander et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes

(2010) Hua Liu et al.   HEPATOLOGY

Modeling inherited metabolic disorders of the liver using human induced pluripotent stem cells

(2010) S. Tamir Rashid et al.   JOURNAL OF CLINICAL INVESTIGATION

A nonviral minicircle vector for deriving human iPS cells

(2010) Fangjun Jia et al.   NATURE METHODS

Regulation of somatic cell reprogramming through inducible mir-302 expression

(2010) Shi-Lung Lin et al.   NUCLEIC ACIDS RESEARCH

Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening

(2010) Melissa A. Baxter et al.   Stem Cell Research

Generation of Liver Disease-Specific Induced Pluripotent Stem Cells Along with Efficient Differentiation to Functional Hepatocyte-Like Cells

(2010) Arefeh Ghodsizadeh et al.   Stem Cell Reviews and Reports

Differentiation and Characterization of Metabolically Functioning Hepatocytes from Human Embryonic Stem Cells

(2010) Yuyou Duan et al.   STEM CELLS

Comparative Analysis of Human Embryonic Stem Cell and Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells Reveals Current Drawbacks and Possible Strategies for Improved Differentiation

(2010) Justyna Jozefczuk et al.   STEM CELLS AND DEVELOPMENT

Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells

(2009) Zhihua Song et al.   CELL RESEARCH

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

(2009) Dohoon Kim et al.   Cell Stem Cell

Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins

(2009) Hongyan Zhou et al.   Cell Stem Cell

Public Perceptions of the Pharmaceutical Industry and Drug Safety

(2009) Axel K. Olsen et al.   DRUG SAFETY

Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells

(2009) Karim Si-Tayeb et al.   HEPATOLOGY

Generation of functional human hepatic endoderm from human induced pluripotent stem cells

(2009) Gareth J. Sullivan et al.   HEPATOLOGY

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development

(2009) Thomas Touboul et al.   HEPATOLOGY

Patenting human pluripotent cells: balancing commercial, academic and ethical interests

(2009) G. Bahadur et al.   HUMAN REPRODUCTION

Hepatocyte-like cells derived from human embryonic stem cells specifically via definitive endoderm and a progenitor stage

(2009) Gabriella Brolén et al.   JOURNAL OF BIOTECHNOLOGY

Virus-free induction of pluripotency and subsequent excision of reprogramming factors

(2009) Keisuke Kaji et al.   NATURE

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

(2009) Knut Woltjen et al.   NATURE

Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon

(2009) Kosuke Yusa et al.   NATURE METHODS

Adverse Drug Reactions in Hospital In-Patients: A Prospective Analysis of 3695 Patient-Episodes

(2009) Emma C. Davies et al.   PLoS One

Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

(2009) J. Yu et al.   SCIENCE

Transcriptional Profiling of Human Embryonic Stem Cells Differentiating to Definitive and Primitive Endoderm and Further Toward the Hepatic Lineage

(2009) Jane Synnergren et al.   STEM CELLS AND DEVELOPMENT

Understanding the role of reactive metabolites in drug-induced hepatotoxicity: state of the science

(2008) Daniel J Antoine et al.   Expert Opinion on Drug Metabolism & Toxicology

Differentiation and Transplantation of Human Embryonic Stem Cell–Derived Hepatocytes

(2008) Hesham Basma et al.   GASTROENTEROLOGY

Differentiation of mouse and human embryonic stem cells into hepatic lineages

(2008) Nobuaki Shiraki et al.   GENES TO CELLS

Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?

(2008) P Sancho-Bru et al.   GUT

Dissecting direct reprogramming through integrative genomic analysis

(2008) Tarjei S. Mikkelsen et al.   NATURE

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2

(2008) Danwei Huangfu et al.   NATURE BIOTECHNOLOGY

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling

(2008) D. C. Hay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene Regulation by Transcription Factors and MicroRNAs

(2008) O. Hobert   SCIENCE

Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells

(2008) Sadhana Agarwal et al.   STEM CELLS