NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics
出版年份 2015 全文链接
标题
NMR and MD Studies Reveal That the Isolated Dengue NS3 Protease Is an Intrinsically Disordered Chymotrypsin Fold Which Absolutely Requests NS2B for Correct Folding and Functional Dynamics
作者
关键词
-
出版物
PLoS One
Volume 10, Issue 8, Pages e0134823
出版商
Public Library of Science (PLoS)
发表日期
2015-08-11
DOI
10.1371/journal.pone.0134823
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Mechanism for transforming cytosolic SOD1 into integral membrane proteins of organelles by ALS-causing mutations
- (2015) Liangzhong Lim et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- Classification of Intrinsically Disordered Regions and Proteins
- (2014) Robin van der Lee et al. CHEMICAL REVIEWS
- Binding mode of the activity-modulating C-terminal segment of NS2B to NS3 in the dengue virus NS2B-NS3 protease
- (2014) Laura de la Cruz et al. FEBS Journal
- The dengue virus NS2B-NS3 protease retains the closed conformation in the complex with BPTI
- (2014) Wan-Na Chen et al. FEBS LETTERS
- TDP-43 N terminus encodes a novel ubiquitin-like fold and its unfolded form in equilibrium that can be shifted by binding to ssDNA
- (2014) Haina Qin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus
- (2013) Muslum Yildiz et al. ACS Chemical Biology
- A small compound targeting the interaction between nonstructural proteins 2B and 3 inhibits dengue virus replication
- (2013) Sabar Pambudi et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- NMR Analysis of a Novel Enzymatically Active Unlinked Dengue NS2B-NS3 Protease Complex
- (2013) Young Mee Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The global distribution and burden of dengue
- (2013) Samir Bhatt et al. NATURE
- New Binding Site Conformations of the Dengue Virus NS3 Protease Accessed by Molecular Dynamics Simulation
- (2013) Hugo de Almeida et al. PLoS One
- Structural biology of dengue virus enzymes: Towards rational design of therapeutics
- (2012) Christian G. Noble et al. ANTIVIRAL RESEARCH
- Determination of Secondary Structure Populations in Disordered States of Proteins Using Nuclear Magnetic Resonance Chemical Shifts
- (2012) Carlo Camilloni et al. BIOCHEMISTRY
- Early Dengue Virus Protein Synthesis Induces Extensive Rearrangement of the Endoplasmic Reticulum Independent of the UPR and SREBP-2 Pathway
- (2012) José Peña et al. PLoS One
- Intrinsically Unstructured Domain 3 of Hepatitis C Virus NS5A Forms a “Fuzzy Complex” with VAPB-MSP Domain Which Carries ALS-Causing Mutations
- (2012) Garvita Gupta et al. PLoS One
- Binding of Low Molecular Weight Inhibitors Promotes Large Conformational Changes in the Dengue Virus NS2B-NS3 Protease: Fold Analysis by Pseudocontact Shifts
- (2011) Laura de la Cruz et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation
- (2011) C. G. Noble et al. JOURNAL OF VIROLOGY
- New Merck and Vertex drugs raise standard of care in hepatitis C
- (2011) Cormac Sheridan NATURE BIOTECHNOLOGY
- Organelle-Like Membrane Compartmentalization of Positive-Strand RNA Virus Replication Factories
- (2010) Johan A. den Boon et al. Annual Review of Microbiology
- Novel Dengue Virus-Specific NS2B/NS3 Protease Inhibitor, BP2109, Discovered by a High-Throughput Screening Assay
- (2010) Chi-Chen Yang et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Elimination of the Native Structure and Solubility of the hVAPB MSP Domain by the Pro56Ser Mutation That Causes Amyotrophic Lateral Sclerosis
- (2010) Jiahai Shi et al. BIOCHEMISTRY
- Dengue: a continuing global threat
- (2010) Maria G. Guzman et al. NATURE REVIEWS MICROBIOLOGY
- Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis
- (2010) N. S. Heaton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Best Practices in Dengue Surveillance: A Report from the Asia-Pacific and Americas Dengue Prevention Boards
- (2010) Mark E. Beatty et al. PLoS Neglected Tropical Diseases
- A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum
- (2009) Elisa Fasana et al. FASEB JOURNAL
- Insight into “insoluble proteins” with pure water
- (2009) Jianxing Song FEBS LETTERS
- Quantifying Correlations Between Allosteric Sites in Thermodynamic Ensembles
- (2009) Christopher L. McClendon et al. Journal of Chemical Theory and Computation
- NMR Evidence for Forming Highly Populated Helical Conformations in the Partially Folded hNck2 SH3 Domain
- (2008) Jingxian Liu et al. BIOPHYSICAL JOURNAL
- Structural proteomics of dengue virus
- (2008) Rushika Perera et al. CURRENT OPINION IN MICROBIOLOGY
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- Mechanism of NS2B-Mediated Activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and Bioassays
- (2008) Z. Zuo et al. JOURNAL OF VIROLOGY
- Modification of intracellular membrane structures for virus replication
- (2008) Sven Miller et al. NATURE REVIEWS MICROBIOLOGY
- HIV-1 protease folding and the design of drugs which do not create resistance
- (2007) RA Broglia et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started