Review
Biochemistry & Molecular Biology
Deeksha Marothia, Navdeep Kaur, Chetna Jhamat, Ipsa Sharma, Pratap Kumar Pati
Summary: Biotic and abiotic stresses have negative effects on plant's development and productivity. Researchers are studying the stress induced responses in plants and strategies to produce stress tolerant crops. Recent interest has focused on exploring the role of lectins in regulating biological responses in plants. Lectins are proteins that form reversible linkages with glycoconjugates. The involvement of plant lectins in stress tolerance is not fully understood and further research in this area could lead to improvements in crop production.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Infectious Diseases
Marilia A. Sena, Priscila Mayrelle da Silva Castanha, Ana Beatriz Giles Guimaraes, Paula Alexandra dos Santos Oliveira, Maria Almerice Lopes da Silva, Marli Tenorio Cordeiro, Patricia Moura, Cynthia Braga, Luydson Richardson Silva Vasconcelos
Summary: The study found that variations in the MBL2 gene are associated with susceptibility to dengue infection in children. Lower levels of serum MBL are associated with dengue infection, while intermediate to high levels of serum MBL are associated with protection against dengue infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Keicyanne Fernanda Lessa dos Anjos, Cynarha Daysy Cardoso da Silva, Mary Angela Aranda de Souza, Alessandra Batista de Mattos, Luana Cassandra Breitenbach Barroso Coelho, Giovanna Machado, Janaina Viana de Melo, Regina Celia Bressan Queiroz de Figueiredo
Summary: Titanium and its alloys are commonly used biomaterials for medical and dental applications due to their mechanical and physical properties. In this study, titanium dioxide nanotubes (TiO2NTs) were functionalized with a lectin from the plasma of the fish Oreochromis niloticus to enhance adhesion, proliferation, and osteogenic activity of osteoblast-like cells, ultimately improving the biocompatibility of titanium-based biomaterials. The successful incorporation of the lectin on the nanotubes was confirmed through various characterization techniques.
Article
Biotechnology & Applied Microbiology
Metin Uysalol, Suheyla Gumus, Raif Yildiz, Ezgi Pasli Uysalol, Sacide Pehlivan, Mustafa Pehlivan, Istemi Serin
Summary: This study revealed a difference in the distribution of different MBL2 genotypes in patients diagnosed with acute bronchiolitis and pneumonia, with genotypes associated with low MBL expression being more common in pneumonia and severe infection cases. The findings underscore the importance of MBL polymorphisms and their expression in infections.
Article
Chemistry, Analytical
Gizem Erol, Patricia Perez Schmidt, Alessia Pancaro, Javier M. Melo Diaz, Africa G. Barrientos, John Porter, Laura Polito, Michal Szymonik, Inge Nelissen, Daniel I. R. Spencer, Arianna Piotti, Marten Beeg, Maria-Grazia De Simoni, Stefano Fumagalli, Marco Gobbi
Summary: Circulating mannose-binding lectin (MBL) plays a crucial role in tissue damage caused by ischemic events. A new surface plasmon resonance (SPR) assay was developed to screen compounds inhibiting the binding of MBL to damaged endothelium. The assay successfully detected MBL binding and identified inhibitory effects of mannose, mannose residues carrying glycan, and mannose-coated gold nanoparticles.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Immunology
Domenico Mercurio, Arianna Piotti, Alessia Valente, Marco Oggioni, Yolanda Ponstein, Edwin Van Amersfoort, Marco Gobbi, Stefano Fumagalli, Maria-Grazia De Simoni
Summary: The study demonstrates that rhC1INH shows stronger neuroprotective effects after experimental ischemia/reperfusion injury in the brain, reducing behavioral deficits and neuronal loss, decreasing MBL deposition in the brain, and reducing the formation of complement C4b active fragments. In contrast, pdC1INH, despite having a longer plasma residence time, does not exhibit these neuroprotective effects. Therefore, rhC1INH may be a promising drug for stroke as it effectively inhibits MBL.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Medicine, General & Internal
Jana Mrazkova, Petr Sistek, Jan Lochman, Lydie Izakovicova Holla, Zdenek Danek, Petra Borilova Linhartova
Summary: The study aims to design and validate a sensitive and economical method for determining MBL2 haplogenotypes. A high-throughput and cost-effective SNaPshot assay for MBL2 genotyping is developed, along with a freely available online application for the calculation of haplogenotypes from SNPs.
Article
Multidisciplinary Sciences
Zihao Li, Mian Wang, Hua Zhong, Xin Huang, Xinyin Wu, Xian Zhang, Jing Wang, Jing Deng, Mengshi Chen, Lizhang Chen, Hongzhuan Tan
Summary: The study found that specific SNPs of the MASP2 gene (rs12711521 and rs7548659) are associated with susceptibility to TB, and negative interactions were observed between tea drinking and these MASP2 gene SNPs.
SCIENTIFIC REPORTS
(2021)
Article
Veterinary Sciences
Eva Wattrang, Tina Sorensen Dalgaard, Rikke Brodsgaard Kjaerup, Mohammad Naghizadeh, Susanne Kabell, Helena Eriksson, Robert Soderlund
Summary: This study investigated immune responses to Erysipelothrix rhusiopathiae (ER) infection in chickens bred for high and low serum mannose-binding lectin (MBL) levels. The results showed that the immune response to ER infection varied, and there were no clear differences between chickens with high and low MBL levels. However, antigen-specific T-cell blast transformation was observed in all infected chickens, and the proportions of blast transformed cells were significantly higher in chickens with low MBL levels. This is the first observation of ER-specific T-cells in chickens, indicating a Th1-type immune response.
VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xuelian Zhou, Xuefeng Chen, Li Zhang, Jinna Yuan, Hu Lin, Mingqiang Zhu, Xiaoqin Xu, Guanping Dong, Junfen Fu, Wei Wu
Summary: This study found that MBL protects ECs from ox-LDL-induced injury by inhibiting the binding of LOX1-ox-LDL, and it regulates DC maturation and EC autophagy. Moreover, MBL over-expression can alleviate atherosclerotic plaque formation, influence DC maturation, and down-regulate levels of IL-6, IL-12, and TNF-a.
Article
Chemistry, Medicinal
Jei Ha Lee, Set Byul Lee, Heabin Kim, Jae Min Shin, Moongeun Yoon, Hye Suck An, Jong Won Han
Summary: Bryopsis plumosa lectin BPL2 exhibits high anticancer activity against lung cancer cells, while showing weak toxicity to non-cancerous cells. BPL2 also inhibits cancer cell invasion and migration, and induces downregulation of epithelial-to-mesenchymal transition-related genes. Combination therapy with gefitinib shows a synergistic effect.
Article
Genetics & Heredity
Mona F. Sokkar, Rehab M. Mosaad, Mahmoud Khalil, Lamyaa Kamal
Summary: This study investigated the promoter and exon 1 variants of MBL2 gene in Egyptian meningitis patients and found that the promoter variant c.-290C > G and UTR variant c.-66C > T may be potential risk factors for disease susceptibility. Other exon variants, including c.132C > T, c.161G > A, and c.154C > T, did not show any association with susceptibility or severity of meningitis.
Article
Biochemistry & Molecular Biology
Yanhong Ma, Fanghao Cai, Xiaohan Huang, Huijing Wang, Binfeng Yu, Junni Wang, Wanyun Nie, Kedan Cai, Yi Yang, Jianghua Chen, Liang Xiao, Fei Han
Summary: Increased serum mannose-binding lectin (MBL) level has been proven to correlate with the development of diabetic nephropathy (DN). This study found that MBL promotes the progression of DN by activating the nuclear factor-kappa B pathway in macrophages. This finding provides a new direction for the treatment of DN patients.
Article
Fisheries
Ying Huang, Ying Jiang, Miao-Miao Wang, Min-Yi Chen, Huan-Gen Chen, Heng-Yuan Chen, Wen-Jie Liu, Xiao-Rui Li, Xiao-Lei Han
Summary: This study cloned and characterized a mannose-binding lectin (MBL) called PcMBL from the crayfish Procambarus clarkii. PcMBL plays important roles in nonself recognition and clearance of invading microorganisms. It was found that PcMBL can influence the transcription of antimicrobial peptide genes and has the ability to bind to various microorganisms and carbohydrates. Furthermore, recombinant PcMBL can facilitate bacterial clearance, inhibit biofilm formation and growth, and reduce mortality in infected crayfish.
AQUACULTURE REPORTS
(2023)
Article
Endocrinology & Metabolism
Anne Gedebjerg, Reimar Wernich Thomsen, Alisa Devedzic Kjaergaard, Rudi Steffensen, Jens Steen Nielsen, Jorgen Rungby, Soren Gunnar Friborg, Ivan Brandslund, Steffen Thiel, Henning Beck-Nielsen, Henrik Toft Sorensen, Troels Krarup Hansen, Mette Bjerre
Summary: Using Mendelian randomization principle, this study found that low mannose-binding lectin (MBL) is a weak causal risk factor for developing infections in patients with type 2 diabetes, particularly for bacterial infections. Low MBL expression genotype was associated with increased risk for antimicrobial prescriptions, indicating a potential role in antibiotic treatment.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Letter
Dermatology
Mattias Henning, Kristina Ibler, Isabella Loft, Poul Jennum, Maria Didriksen, Henrik Ullum, Christian Erikstrup, Kaspar Nielsen, Mie Topholm Bruun, Henrik Hjalgrim, Erik Sorensen, Khoa Dinh, Lise Wegner Thorner, Gregor B. Jemec, Ole Pedersen
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Rheumatology
Christian Ammitzboll, Marianne Kragh Thomsen, Jakob Bogh Andersen, Lars Erik Bartels, Marie-Louise From Hermansen, Anders Dahl Johannsen, Clara Elbaek Mistegaard, Susan Mikkelsen, Signe Risbol Vils, Christian Erikstrup, Ellen-Margrethe Hauge, Anne Troldborg
Summary: This study investigated the effect of a two-dose mRNA vaccine on patients with systemic lupus erythematosus or rheumatoid arthritis. The results showed that the vaccine effectively increased patients' antibody levels against SARS-CoV-2 and reduced their fear of COVID-19. However, the use of rituximab, prednisone, and methotrexate had a negative impact on the vaccine response.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Cecilie Henkel, Unnur Styrkarsdottir, Gudmar Thorleifsson, Lilja Stefansdottir, Gyda Bjornsdottir, Karina Banasik, Soren Brunak, Christian Erikstrup, Khoa Manh Dinh, Thomas Folkmann Hansen, Kaspar Rene Nielsen, Mie Topholm Bruun, Joseph Dowsett, Thorsten Brodersen, Dbds Genomic Consortium, Thorgeir E. Thorgeirsson, Kirill Gromov, Mikael Ploug Boesen, Henrik Ullum, Sisse Rye Ostrowski, Ole Birger Pedersen, Kari Stefansson, Anders Troelsen
Summary: This study aimed to investigate the differences in genetic associations between knee and hip osteoarthritis based on joint replacement status. The results showed that genetic correlations varied between patients with knee and hip osteoarthritis, and joint replacement status influenced the genetic associations.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Infectious Diseases
Bertram Kjerulff, Kathrine A. Kaspersen, Khoa M. Dinh, Jens Boldsen, Susan Mikkelsen, Lise T. Erikstrup, Erik Sorensen, Kaspar R. Nielsen, Mie T. Bruun, Henrik Hjalgrim, Ole B. Pedersen, Lise W. Thorner, Henrik Ullum, Sisse R. Ostrowski, Klaus Rostgaard, Carsten B. Pedersen, Torben Sigsgaard, Christian Erikstrup
Summary: Through a study of more than 120,000 Danish blood donors, it was found that smoking is closely related to an increased risk of infection, especially respiratory tract infection, abscesses, and skin infection. These findings indicate that we should pay more attention to the infection risk among smokers.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Immunology
Maarten van Wijhe, Kamille Fogh, Steen Ethelberg, Kasper Karmark Iversen, Henrik Nielsen, Lars Ostergaard, Berit Andersen, Henning Bundgaard, Charlotte S. Jorgensen, Bibi F. Ss Scharff, Svend Ellermann-Eriksen, Isik S. Johansen, Anders Fomsgaard, Tyra Grove Krause, Lothar Wiese, Thea K. Fischer, Kare Molbak, Thomas Benfield, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Anders Koch, Christian Erikstrup, Anne-Marie Vangsted, Anna Irene Vedel Sorensen, Henrik Ullum, Robert Leo Skov, Lone Simonsen, Susanne Dam Nielsen
Summary: This study assessed the burden of long COVID among nonhospitalized adults with PCR-confirmed SARS-CoV-2 infection. The results showed that 25 out of 100 cases reported at least one long-COVID symptom. Infected individuals had worse general health, higher odds of various symptoms, particularly loss of taste and smell, and significantly reduced physical and mental health. Female sex and severity of infection were identified as major risk factors for long COVID.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Article
Genetics & Heredity
Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey M. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Maegi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson
Summary: The study conducted a meta-analysis and identified genetic variants associated with gestational duration and preterm delivery. It revealed the importance of maternal alleles in influencing gestational duration and the complex relationship between gestational duration and birth weight. The study also identified antagonistic pleiotropy, where maternal alleles that increase gestational duration have negative effects on birth weight.
Article
Immunology
Bo L. Honge, Morten N. Andersen, Mikkel S. Petersen, Sanne Jespersen, Candida Medina, David D. S. Te, Bertram Kjerulff, Alex L. Laursen, Holger J. Moller, Christian Wejse, Henrik Krarup, Bjarne K. Moller, Christian Erikstrup
Summary: AIDS-defining illness develops at higher CD4+ T-cell counts in individuals infected with HIV-2 compared with HIV-1-infected, which suggests that the two types of HIV may have different effects on other compartments of the immune system. This study investigated monocyte phenotype, activation, and macrophage-derived extracellular vesicles in individuals with different HIV types. The results showed that HIV-2-positive participants had a less deviated monocyte phenotype from healthy controls and a lower concentration of extracellular CD206 vesicles compared with HIV-1-positive participants.
Article
Genetics & Heredity
Maria Nethander, Sofia Moverare-Skrtic, Anders Kampe, Eivind Coward, Ene Reimann, Louise Grahnemo, Eva Borbely, Zsuzsanna Helyes, Thomas Funck-Brentano, Martine Cohen-Solal, Juha Tuukkanen, Antti Koskela, Jianyao Wu, Lei Li, Tianyuan Lu, Maiken E. Gabrielsen, Reedik Estonian Biobank Res Team, Reedik Magi, Mari Hoff, Ulf H. Lerner, Petra Henning, Henrik Ullum, Christian Erikstrup, Soren Brunak, Tiinamaija DBDS Genomic Consortium, Arnulf Langhammer, Tiinamaija Tuomi, Asmundur Oddsson, Kari Stefansson, Ulrika Pettersson-Kymmer, Sisse Rye Ostrowski, Ole Birger Vesterager Pedersen, Unnur Styrkarsdottir, Outi Makitie, Kristian Hveem, J. Brent Richards, Claes Ohlsson
Summary: This study identified 43 loci associated with forearm fracture through genome-wide association analysis, including some influencing bone quality parameters. Functional studies of one of these loci revealed that Tac4 knockout mice exhibit reduced mechanical bone strength without affecting bone mineral density.
Article
Genetics & Heredity
Gyda Bjornsdottir, Mona A. Chalmer, Lilja Stefansdottir, Astros Th. Skuladottir, Gudmundur Einarsson, Margret Andresdottir, Doruk Beyter, Egil Ferkingstad, Solveig Gretarsdottir, Bjarni V. Halldorsson, Gisli H. Halldorsson, Anna Helgadottir, Hannes Helgason, Grimur Hjorleifsson Eldjarn, Adalbjorg Jonasdottir, Aslaug Jonasdottir, Ingileif Jonsdottir, Kirk U. Knowlton, Lincoln D. Nadauld, Sigrun H. Lund, Olafur Th. Magnusson, Pall Melsted, Kristjan H. S. Moore, Asmundur Oddsson, Pall I. Olason, Asgeir Sigurdsson, Olafur A. Stefansson, Jona Saemundsdottir, Gardar Sveinbjornsson, Vinicius Tragante, Unnur Unnsteinsdottir, G. Bragi Walters, Florian Zink, Linn Rodevand, Ole A. Andreassen, Jannicke Igland, Rolv T. Lie, Jan Haavik, Karina Banasik, Soren Brunak, Maria Didriksen, Mie T. Bruun, Christian Erikstrup, Lisette J. A. Kogelman, Kaspar R. Nielsen, Erik Sorensen, Ole B. Pedersen, Henrik Ullum, Gisli Masson, Unnur Thorsteinsdottir, Jes Olesen, Petur Ludvigsson, Olafur Thorarensen, Anna Bjornsdottir, Gudrun R. Sigurdardottir, Olafur A. Sveinsson, Sisse R. Ostrowski, Hilma Holm, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Patrick Sulem, Hreinn Stefansson, Thorgeir E. Thorgeirsson, Thomas F. Hansen, Kari Stefansson
Summary: This study combines large GWAS datasets from six European populations to investigate the main subtypes of migraine and identifies new susceptibility loci associated with migraine and its subtypes. Rare variants with large effects on PRRT2, SCN11A, and KCNK5 genes are found to be related to migraine. These findings provide new insights into the complex biology of migraine and its subtypes, offering potential for therapeutic interventions.
Article
Primary Health Care
Isabella Gringer Rousing, Peter Vedsted, Peter Hjertholm, Per Kallestrup, Marie-Louise Ladegaard Baun, Line Flytkjaer Virgilsen
Summary: This study aimed to identify a window of opportunity for earlier diagnosis of ovarian cancer by analyzing the health care use in primary care and hospitals. The results showed that women with ovarian cancer had significantly higher contact rates to general practice from five months prior to diagnosis compared to non-cancerous women. An increased use of transvaginal ultrasound and gynaecologist was also seen for ovarian cancer cases six to eight months before diagnosis.
Article
Environmental Sciences
Sophie Amalie Hamann, Lene Thorup, Cecilie Blenstrup Patsche, Lena Hohwu, Vibeke Elisabeth Hjortdal, Bishal Gyawali, Dinesh Neupane, Per Kallestrup
Summary: There is an association between socio-economic status and nutritional status among Nepalese school children, with students from lower and upper income households having a higher tendency to be overweight. Furthermore, there is a simultaneous occurrence of stunting and overweight in some students.
JOURNAL OF HEALTH POPULATION AND NUTRITION
(2023)
Article
Dermatology
Pernille Lindso Andersen, Gregor Borut Ernst Jemec, Christian Erikstrup, Maria Didriksen, Khoa Manh Dinh, Susan Mikkelsen, Mie Topholm Bruun, Henrik Hjalgrim, Thomas Folkmann Hansen, Susanne Gjorup Saekmose, Sisse Rye Ostrowski, Ole Birger Pedersen, Ditte Marie Saunte
Summary: This study found two protective HLA alleles, DQB1*06:04 and DRB1*13:02, that can reduce the risk of onychomycosis.
SKIN APPENDAGE DISORDERS
(2023)
Article
Public, Environmental & Occupational Health
A. J. Christensen, J. Mwayi, J. Mbabazi, M. Juncker, P. Kallestrup, C. Kraef
Summary: This study aimed to identify risk factors for precancerous cervical lesions and factors associated with treatment delay among women in rural Busoga Region, Uganda. The results suggest a need for broad-scale cervical cancer screening targeting all women of reproductive age, as abnormal vaginal bleeding was the only substantial risk factor identified. The study emphasizes the importance of increased awareness, resources, and funding to achieve global cervical cancer elimination.
Article
Dermatology
P. Lindso Andersen, G. B. Jemec, C. Erikstrup, M. Didriksen, K. M. Dinh, S. Mikkelsen, E. Sorensen, K. R. Nielsen, M. T. Bruun, H. Hjalgrim, T. F. Hansen, S. G. Saekmose, S. R. Ostrowski, D. M. L. Saunte, O. B. Pedersen
Summary: This study investigated the association between HLA alleles and MRSD, identifying five novel associations and confirming one previous association.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)