Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis

A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements

(2014) Hongseok Ha et al.   BMC GENOMICS

Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice

(2014) J. Castaneda et al.   EMBO JOURNAL

Phosphatidic Acid (PA)-preferring Phospholipase A1Regulates Mitochondrial Dynamics

(2014) Takashi Baba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

piRNAs Warrant Investigation in Rett Syndrome: An Omics Perspective

(2013) Alka Saxena et al.   DISEASE MARKERS

Dysfunctional cardiac mitochondrial bioenergetic, lipidomic, and signaling in a murine model of Barth syndrome

(2013) Michael A. Kiebish et al.   JOURNAL OF LIPID RESEARCH

Barth syndrome

(2013) Sarah LN Clarke et al.   Orphanet Journal of Rare Diseases

GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells

(2013) Y. Shiromoto et al.   RNA

Environmental origins of congenital heart disease: The heart–placenta connection

(2013) James Huhta et al.   Seminars in Fetal & Neonatal Medicine

Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome

(2013) Jan Dudek et al.   Stem Cell Research

Diminished Exercise Capacity and Mitochondrial bc1 Complex Deficiency in Tafazzin-Knockdown Mice

(2013) Corey Powers et al.   Frontiers in Physiology

Cardiolipin remodeling and the function of tafazzin

(2012) Michael Schlame   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Roles for the lipid-signaling enzyme MitoPLD in mitochondrial dynamics, piRNA biogenesis, and spermatogenesis

(2012) Qun Gao et al.   BMB Reports

A Role for Neuronal piRNAs in the Epigenetic Control of Memory-Related Synaptic Plasticity

(2012) Priyamvada Rajasethupathy et al.   CELL

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo

(2012) Hannah Schachtner et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Seven functional classes of Barth syndrome mutation

(2012) Kevin Whited et al.   HUMAN MOLECULAR GENETICS

Structure and function of Zucchini endoribonuclease in piRNA biogenesis

(2012) Hiroshi Nishimasu et al.   NATURE

The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis

(2012) Jonathan J. Ipsaro et al.   NATURE

The physical state of lipid substrates provides transacylation specificity for tafazzin

(2012) Michael Schlame et al.   Nature Chemical Biology

Long interspersed nuclear elements (LINEs) show tissue-specific, mosaic genome and methylation-unrestricted, widespread expression of noncoding RNAs in somatic tissues of the rat

(2012) Deepak K. Singh et al.   RNA Biology

Tafazzin Knockdown in Mice Leads to a Developmental Cardiomyopathy With Early Diastolic Dysfunction Preceding Myocardial Noncompaction

(2012) Colin K. L. Phoon et al.   Journal of the American Heart Association

MITOPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline

(2011) Toshiaki Watanabe et al.   DEVELOPMENTAL CELL

piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling

(2011) Huiyan Huang et al.   DEVELOPMENTAL CELL

Subcellular Fate and Off-Target Effects of siRNA, shRNA, and miRNA

(2011) Saurabh Singh et al.   PHARMACEUTICAL RESEARCH

Germline Stem Cell Gene PIWIL2 Mediates DNA Repair through Relaxation of Chromatin

(2011) De-Tao Yin et al.   PLoS One

Identification of piRNAs in the central nervous system

(2011) E. J. Lee et al.   RNA

Characterization of a Transgenic Short Hairpin RNA-Induced Murine Model of Tafazzin Deficiency

(2010) Meghan S. Soustek et al.   HUMAN GENE THERAPY

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

(2010) Devrim Acehan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A LINE-1 component to human aging: Do LINE elements exact a longevity cost for evolutionary advantage?

(2010) Georges St. Laurent et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Cardiolipin and monolysocardiolipin analysis in fibroblasts, lymphocytes, and tissues using high-performance liquid chromatography–mass spectrometry as a diagnostic test for Barth syndrome

(2009) Riekelt H. Houtkooper et al.   ANALYTICAL BIOCHEMISTRY

Cardiolipin acts as a mitochondrial signalling platform to launch apoptosis

(2009) Zachary T. Schug et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The enigmatic role of tafazzin in cardiolipin metabolism

(2009) Riekelt H. Houtkooper et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Comparative assessment of siRNA and shRNA off target effects: what is slowing clinical development

(2009) D D Rao et al.   CANCER GENE THERAPY

The TDRD9-MIWI2 Complex Is Essential for piRNA-Mediated Retrotransposon Silencing in the Mouse Male Germline

(2009) Masanobu Shoji et al.   DEVELOPMENTAL CELL

Identification of a Cardiolipin-specific Phospholipase Encoded by the GeneCLD1(YGR110W) in Yeast

(2009) Andreas Beranek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation

(2009) Kehkooi Kee et al.   NATURE

Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome

(2009) A. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice

(2009) Alexei A. Aravin et al.   PLoS Genetics

Chronic doxycycline exposure accelerates left ventricular hypertrophy and progression to heart failure in mice after thoracic aorta constriction

(2008) Laurent Vinet et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mice Deficient for a Small Cluster of Piwi-Interacting RNAs Implicate Piwi-Interacting RNAs in Transposon Control1

(2008) Mingang Xu et al.   BIOLOGY OF REPRODUCTION

Mouse Maelstrom, a Component of Nuage, Is Essential for Spermatogenesis and Transposon Repression in Meiosis

(2008) Sarah F.C. Soper et al.   DEVELOPMENTAL CELL