Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 18, Issue 5, Pages 245-250Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2013.05.003
Keywords
Cardiac embryonic development; Congenital heart disease; Fetal echocardiography; Folate; Birth defects
Categories
Funding
- NHLBI
- American Heart Association
- Suncoast Cardiovascular Education and Research Foundation
- Mason Endowment of USF Foundation
Ask authors/readers for more resources
Although the mammalian embryo is well protected in the uterus, environmental chemicals, drugs, and maternal nutritional imbalances can interfere with regulatory pathways directing placental and embryonic development early in gestation. Embryonic cells are most susceptible to environmental influences during cellular specification and differentiation stages. Because biochemical differentiation precedes morphological outcome often by days, the period of susceptibility to environmental chemicals expectedly precedes visible morphogenic effects. The cellular mechanisms by which drugs and other environmental factors disrupt embryonic development and induce cardiac abnormalities have remained undefined. (C) 2013 Published by Elsevier Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available