Prion Pathogenesis in the Absence of NLRP3/ASC Inflammasomes

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

(2014) Bernardo S Franklin et al.   NATURE IMMUNOLOGY

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells

(2013) Mario Nuvolone et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Abnormal Activation of Microglia Accompanied with Disrupted CX3CR1/CX3CL1 Pathway in the Brains of the Hamsters Infected with Scrapie Agent 263K

(2013) Wu-Ling Xie et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia

(2013) Fushan Shi et al.   JOURNAL OF NEUROIMMUNOLOGY

Brain microglia were activated in sporadic CJD but almost unchanged in fatal familial insomnia and G114V genetic CJD

(2013) Qi Shi et al.   Virology Journal

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

(2012) Iva Hafner-Bratkovič et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Antibody-Mediated Inhibition of Integrin α5β1 Blocks Neurotoxic Prion Peptide PrP106–126-Induced Activation of BV2 Microglia

(2012) Jiaxin Chang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Early Cytokine Elevation, PrPres Deposition, and Gliosis in Mouse Scrapie: No Effect on Disease by Deletion of Cytokine Genes IL-12p40 and IL-12p35

(2012) D. Tribouillard-Tanvier et al.   JOURNAL OF VIROLOGY

Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection

(2012) D. Ishibashi et al.   JOURNAL OF VIROLOGY

Nod1, but not the ASC inflammasome, contributes to induction of IL-1β secretion in human trophoblasts after sensing of Chlamydia trachomatis

(2012) P B Kavathas et al.   Mucosal Immunology

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome

(2012) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

Prion Disease and the Innate Immune System

(2012) Barry Bradford et al.   Viruses-Basel

Believe it or not: how much can we rely on published data on potential drug targets?

(2011) Florian Prinz et al.   NATURE REVIEWS DRUG DISCOVERY

The Strain-Encoded Relationship between PrPSc Replication, Stability and Processing in Neurons is Predictive of the Incubation Period of Disease

(2011) Jacob I. Ayers et al.   PLoS Pathogens

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

(2010) Jan Kranich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Caspase-1 Independent IL-1  Production Is Critical for Host Resistance to Mycobacterium tuberculosis and Does Not Require TLR Signaling In Vivo

(2010) K. D. Mayer-Barber et al.   JOURNAL OF IMMUNOLOGY

Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1

(2010) Erin McElvania TeKippe et al.   PLoS One

The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent

(2010) Philippe Tixador et al.   PLoS Pathogens

Inflammatory arthritis in caspase 1 gene–deficient mice: Contribution of proteinase 3 to caspase 1–independent production of bioactive interleukin-1β

(2009) Leo A. B. Joosten et al.   ARTHRITIS AND RHEUMATISM

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases

(2009) Nils Gehlenborg et al.   Database-The Journal of Biological Databases and Curation

Genes contributing to prion pathogenesis

(2008) G. Tamguney et al.   JOURNAL OF GENERAL VIROLOGY

Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice

(2008) D. S. Spinner et al.   JOURNAL OF VIROLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The POM Monoclonals: A Comprehensive Set of Antibodies to Non-Overlapping Prion Protein Epitopes

(2008) Magdalini Polymenidou et al.   PLoS One