Prion Disease and the Innate Immune System

Scrapie Pathogenesis: The Role of Complement C1q in Scrapie Agent Uptake by Conventional Dendritic Cells

(2014) A. Flores-Langarica et al.   JOURNAL OF IMMUNOLOGY

DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells

(2012) K. K. Hosszu et al.   BLOOD

B Cell-Specific S1PR1 Deficiency Blocks Prion Dissemination between Secondary Lymphoid Organs

(2012) S. W. F. Mok et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Brucella abortus Exploits a Cellular Prion Protein on Intestinal M Cells as an Invasive Receptor

(2012) G. Nakato et al.   JOURNAL OF IMMUNOLOGY

Determining the role of mononuclear phagocytes in prion neuroinvasion from the skin

(2012) Gwennaelle J. Wathne et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Targeting of prion-infected lymphoid cells to the central nervous system accelerates prion infection

(2012) Yael Friedman-Levi et al.   Journal of Neuroinflammation

Isolation of Novel Synthetic Prion Strains by Amplification in Transgenic Mice Coexpressing Wild-Type and Anchorless Prion Proteins

(2012) G. J. Raymond et al.   JOURNAL OF VIROLOGY

Early Cytokine Elevation, PrPres Deposition, and Gliosis in Mouse Scrapie: No Effect on Disease by Deletion of Cytokine Genes IL-12p40 and IL-12p35

(2012) D. Tribouillard-Tanvier et al.   JOURNAL OF VIROLOGY

M cell-depletion blocks oral prion disease pathogenesis

(2012) D S Donaldson et al.   Mucosal Immunology

IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia

(2012) Yaming Wang et al.   NATURE IMMUNOLOGY

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

(2012) Reuben Saba et al.   PLoS One

The diverse roles of mononuclear phagocytes in prion disease pathogenesis

(2012) Gwennaelle J. Wathne et al.   Prion

Phenotypic characterization of cells participating in transport of prion protein aggregates across the intestinal mucosa of sheep

(2012) Caroline Piercey Åkesson et al.   Prion

Reaction of complement factors varies with prion strains in vitro and in vivo

(2012) Rie Hasebe et al.   VIROLOGY

Incunabular Immunological Events in Prion Trafficking

(2012) Brady Michel et al.   Scientific Reports

Plasmacytoid Dendritic Cells Sequester High Prion Titres at Early Stages of Prion Infection

(2012) Rocio Castro-Seoane et al.   PLoS Pathogens

Mutation and Selection of Prions

(2012) Charles Weissmann   PLoS Pathogens

Regulatory effects of TLR2 on megakaryocytic cell function

(2011) L. M. Beaulieu et al.   BLOOD

Defining the anatomical localisation of subsets of the murine mononuclear phagocyte system using integrin alpha X (Itgax, CD11c) and colony stimulating factor 1 receptor (Csf1r, CD115) expression fails to discriminate dendritic cells from macrophages

(2011) Barry M. Bradford et al.   IMMUNOBIOLOGY

Expression of mesenchyme-specific gene signatures by follicular dendritic cells: insights from the meta-analysis of microarray data from multiple mouse cell populations

(2011) Neil A. Mabbott et al.   IMMUNOLOGY

Systemic Inflammation Modulates Fc Receptor Expression on Microglia during Chronic Neurodegeneration

(2011) K. Lunnon et al.   JOURNAL OF IMMUNOLOGY

DC-SIGN ligation greatly affects dendritic cell differentiation from monocytes compromising their normal function

(2011) Urban Švajger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of Chemoattractive Factors Involved in the Migration of Bone Marrow-Derived Mesenchymal Stem Cells to Brain Lesions Caused by Prions

(2011) C.-H. Song et al.   JOURNAL OF VIROLOGY

Accelerated Shedding of Prions following Damage to the Olfactory Epithelium

(2011) R. A. Bessen et al.   JOURNAL OF VIROLOGY

C1q regulation of dendritic cell development from monocytes with distinct cytokine production and T cell stimulation

(2011) Boon King Teh et al.   MOLECULAR IMMUNOLOGY

Complement in the brain

(2011) Robert Veerhuis et al.   MOLECULAR IMMUNOLOGY

Blocking of FcR Suppresses the Intestinal Invasion of Scrapie Agents

(2011) Ryuta Uraki et al.   PLoS One

All Clinically-Relevant Blood Components Transmit Prion Disease following a Single Blood Transfusion: A Sheep Model of vCJD

(2011) Sandra McCutcheon et al.   PLoS One

Absence of Colony Stimulation Factor-1 Receptor Results in Loss of Microglia, Disrupted Brain Development and Olfactory Deficits

(2011) Bryna Erblich et al.   PLoS One

Transcriptional profiling of peripheral lymphoid tissue reveals genes and networks linked to SSBP/1 scrapie pathology in sheep

(2011) Anton Gossner et al.   VETERINARY MICROBIOLOGY

Follicular Dendritic Cell-Specific Prion Protein (PrPc) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen

(2011) Laura McCulloch et al.   PLoS Pathogens

Prion Uptake in the Gut: Identification of the First Uptake and Replication Sites

(2011) Pekka Kujala et al.   PLoS Pathogens

Aerosols Transmit Prions to Immunocompetent and Immunodeficient Mice

(2011) Johannes Haybaeck et al.   PLoS Pathogens

Cellular prion protein released on exosomes from macrophages binds to Hsp70

(2010) G. Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

CD137 Is Required for M Cell Functional Maturation but Not Lineage Commitment

(2010) En Hui Hsieh et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA expression in maturing murine megakaryocytes

(2010) J. B. Opalinska et al.   BLOOD

Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations

(2010) Neil A. Mabbott et al.   IMMUNOBIOLOGY

Pro-prion Binds Filamin A, Facilitating Its Interaction with Integrin β1, and Contributes to Melanomagenesis

(2010) Chaoyang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Murine Cecal Patch M Cells Transport Infectious Prions In Vivo

(2010) Neil Foster et al.   JOURNAL OF INFECTIOUS DISEASES

B Cells and Platelets Harbor Prion Infectivity in the Blood of Deer Infected with Chronic Wasting Disease

(2010) C. K. Mathiason et al.   JOURNAL OF VIROLOGY

Prion Replication in the Hematopoietic Compartment Is Not Required for Neuroinvasion in Scrapie Mouse Model

(2010) Corinne Loeuillet et al.   PLoS One

Complement in neuroprotection and neurodegeneration

(2010) Vijay Yanamadala et al.   TRENDS IN MOLECULAR MEDICINE

Immune cell types involved in early uptake and transport of recombinant mouse prion protein in Peyer’s patches of calves

(2009) Sein Lwin et al.   CELL AND TISSUE RESEARCH

Evidence that a C1q/C1qR system regulates monocyte-derived dendritic cell differentiation at the interface of innate and acquired immunity

(2009) Kinga K. Hosszu et al.   Innate Immunity

Prion Protein Expression and Release by Mast Cells After Activation

(2009) D. James Haddon et al.   JOURNAL OF INFECTIOUS DISEASES

Increased Proportions of C1 Truncated Prion Protein Protect Against Cellular M1000 Prion Infection

(2009) Victoria Lewis et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Selective reduction in microglia density and function in the white matter of colony-stimulating factor-1-deficient mice

(2009) Yoichi Kondo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Infection of Cell Lines with Experimental and Natural Ovine Scrapie Agents

(2009) M. H. Neale et al.   JOURNAL OF VIROLOGY

Analysis of Protein Levels of 24 Cytokines in Scrapie Agent-Infected Brain and Glial Cell Cultures from Mice Differing in Prion Protein Expression Levels

(2009) D. Tribouillard-Tanvier et al.   JOURNAL OF VIROLOGY

A systems approach to prion disease

(2009) Daehee Hwang et al.   Molecular Systems Biology

Role of Cellular Prion Proteins in the Function of Macrophages and Dendritic Cells

(2009) Kayako Nitta et al.   PROTEIN AND PEPTIDE LETTERS

Bovine macrophage degradation of scrapie and BSE PrPSc

(2009) Yukiko Sassa et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

The Prion Disease Database: a comprehensive transcriptome resource for systems biology research in prion diseases

(2009) Nils Gehlenborg et al.   Database-The Journal of Biological Databases and Curation

Identification of an Intracellular Site of Prion Conversion

(2009) Zrinka Marijanovic et al.   PLoS Pathogens

Resistance of Chemokine Receptor 6-Deficient Mice to Yersinia Enterocolitica Infection

(2008) Sabine Westphal et al.   AMERICAN JOURNAL OF PATHOLOGY

Prion diseases are efficiently transmitted by blood transfusion in sheep

(2008) F. Houston et al.   BLOOD

Comprehensive transcriptional profiling of prion infection in mouse models reveals networks of responsive genes

(2008) Garrett Sorensen et al.   BMC GENOMICS

Immune evasion of natural killer cells by viruses

(2008) Stipan Jonjić et al.   CURRENT OPINION IN IMMUNOLOGY

Expression profiles of prion and doppel proteins and of their receptors in mouse splenocytes

(2008) Sevda Cordier-Dirikoc et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate immunity to virus infection

(2008) Osamu Takeuchi et al.   IMMUNOLOGICAL REVIEWS

The cellular prion protein is preferentially expressed by CD4+ CD25+ Foxp3+regulatory T cells

(2008) Jeremy D. Isaacs et al.   IMMUNOLOGY

Genes contributing to prion pathogenesis

(2008) G. Tamguney et al.   JOURNAL OF GENERAL VIROLOGY

Bacterial Colitis Increases Susceptibility to Oral Prion Disease

(2008) Christina J. Sigurdson et al.   JOURNAL OF INFECTIOUS DISEASES

Temporary Depletion of CD11c+ Dendritic Cells Delays Lymphoinvasion after Intraperitonal Scrapie Infection

(2008) S. Cordier-Dirikoc et al.   JOURNAL OF VIROLOGY

Accelerated Prion Replication in, but Prolonged Survival Times of, Prion-Infected CXCR3-/- Mice

(2008) C. Riemer et al.   JOURNAL OF VIROLOGY

Neuroinvasion in sheep transmissible spongiform encephalopathies: the role of the haematogenous route

(2008) S. Sisó et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Altered lymphocyte homeostasis after oral prion infection in mouse

(2008) F. Díaz-San Segundo et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY