Methyl-Hydroxylamine as an Efficacious Antibacterial Agent That Targets the Ribonucleotide Reductase Enzyme

The class Ib ribonucleotide reductase from Mycobacterium tuberculosis has two active R2F subunits

(2014) Marta Hammerstad et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Drug development: Time for teamwork

(2014) Mike May   NATURE

Tumor necrosis factor alpha in mycobacterial infection

(2014) Anca Dorhoi et al.   SEMINARS IN IMMUNOLOGY

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

Ribonucleotide reductases: essential enzymes for bacterial life

(2014) Eduard Torrents   Frontiers in Cellular and Infection Microbiology

Radical Scavengers as Ribonucleotide Reductase Inhibitors

(2013) Arijit Basu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Development of Ribonucleotide Reductase Inhibitors: A Review on Structure Activity Relationships

(2013) Narayana Moorthy et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

Connaught and Russian Strains Showed the Highest Direct Antitumor Effects of Different Bacillus Calmette-Guérin Substrains

(2012) Silvia Secanella-Fandos et al.   JOURNAL OF UROLOGY

Class I Ribonucleotide Reductases: Metallocofactor Assembly and Repair In Vitro and In Vivo

(2011) Joseph A. Cotruvo et al.   Annual Review of Biochemistry

Ribonucleotide reductase inhibition by p-alkoxyphenols studied by molecular docking and molecular dynamics simulations

(2011) Jinghui Luo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

DNA building blocks: keeping control of manufacture

(2011) Anders Hofer et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase fromBacillus anthracis

(2011) Mikael Crona et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ribonucleotide reduction - horizontal transfer of a required function spans all three domains

(2010) Daniel Lundin et al.   BMC EVOLUTIONARY BIOLOGY

Pseudomonas aeruginosabiofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies

(2010) Daniel J Hassett et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Evaluation of the Mycobacterium smegmatis and BCG models for the discovery of Mycobacterium tuberculosis inhibitors

(2010) Mudassar Altaf et al.   TUBERCULOSIS

The Antituberculosis Drug Pyrazinamide Affects the Course of Cutaneous Leishmaniasis In Vivo and Increases Activation of Macrophages and Dendritic Cells

(2009) S. Mendez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

RNRdb, a curated database of the universal enzyme family ribonucleotide reductase, reveals a high level of misannotation in sequences deposited to Genbank

(2009) Daniel Lundin et al.   BMC GENOMICS

Hydroxyurea and hydroxamic acid derivatives as antitumor drugs

(2009) Nina Saban et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Hydroxyurea Induces Hydroxyl Radical-Mediated Cell Death in Escherichia coli

(2009) Bryan W. Davies et al.   MOLECULAR CELL

Human Host Defense Peptide LL-37 Prevents Bacterial Biofilm Formation

(2008) J. Overhage et al.   INFECTION AND IMMUNITY

Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy

(2008) C. Lanaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY

MICROBIOLOGY: Desperately Seeking New Antibiotics

(2008) D. J. Payne   SCIENCE

The Epidemic of Antibiotic-Resistant Infections: A Call to Action for the Medical Community from the Infectious Diseases Society of America

(2007) B. Spellberg et al.   CLINICAL INFECTIOUS DISEASES