A Novel Sterol Regulatory Element-Binding Protein Gene (sreA) Identified in Penicillium digitatum Is Required for Prochloraz Resistance, Full Virulence and erg11 (cyp51) Regulation

Novel mutations in CYP51B from Penicillium digitatum involved in prochloraz resistance

(2014) Jinlong Wang et al.   JOURNAL OF MICROBIOLOGY

Zinc Finger Transcription Factors Displaced SREBP Proteins as the Major Sterol Regulators during Saccharomycotina Evolution

(2014) Sarah L. Maguire et al.   PLoS Genetics

Novel Antifungal Drug Discovery Based on Targeting Pathways Regulating the Fungus-Conserved Upc2 Transcription Factor

(2013) Christina Gallo-Ebert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Distinct Roles of Candida albicans Drug Resistance Transcription Factors TAC1 , MRR1 , and UPC2 in Virulence

(2013) Andrea Lohberger et al.   EUKARYOTIC CELL

Genomewide investigation into DNA elements and ABC transporters involved in imazalil resistance inPenicillium digitatum

(2013) Xuepeng Sun et al.   FEMS MICROBIOLOGY LETTERS

Synthesis, Fungicidal Activity, and Sterol 14α-Demethylase Binding Interaction of 2-Azolyl-3,4-dihydroquinazolines on Penicillium digitatum

(2013) Wen-Jin Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Characterization of the sterol 14α-demethylases ofFusarium graminearumidentifies a novel genus-specific CYP51 function

(2013) Jieru Fan et al.   NEW PHYTOLOGIST

Genome sequence of the necrotrophic fungus Penicillium digitatum, the main postharvest pathogen of citrus

(2012) Marina Marcet-Houben et al.   BMC GENOMICS

Gain-of-Function Mutations in UPC2 Are a Frequent Cause of ERG11 Upregulation in Azole-Resistant Clinical Isolates of Candida albicans

(2012) Stephanie A. Flowers et al.   EUKARYOTIC CELL

Regulation of Efflux Pump Expression and Drug Resistance by the Transcription Factors Mrr1, Upc2, and Cap1 in Candida albicans

(2011) Sabrina Schubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Differential Requirement of the Transcription Factor Mcm1 for Activation of the Candida albicans Multidrug Efflux PumpMDR1by Its Regulators Mrr1 and Cap1

(2011) Selene Mogavero et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

SREBP-Dependent Triazole Susceptibility in Aspergillus fumigatus Is Mediated through Direct Transcriptional Regulation oferg11A(cyp51A)

(2011) Sara J. Blosser et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

PdCYP51B, a new putative sterol 14α-demethylase gene of Penicillium digitatum involved in resistance to imazalil and other fungicides inhibiting ergosterol synthesis

(2011) Xuepeng Sun et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

SREBP Coordinates Iron and Ergosterol Homeostasis to Mediate Triazole Drug and Hypoxia Responses in the Human Fungal Pathogen Aspergillus fumigatus

(2011) Michael Blatzer et al.   PLoS Genetics

An A643V Amino Acid Substitution in Upc2p Contributes to Azole Resistance in Well-Characterized Clinical Isolates ofCandida albicans

(2010) Samantha J. Hoot et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis

(2010) Clara M. Bien et al.   EUKARYOTIC CELL

Homology Modeling and Screening of New 14α-Demethylase Inhibitor (DMI) Fungicides Based on Optimized Expression of CYP51 from Ustilago maydis in Escherichia coli

(2010) Rui Han et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Optimised expression and spectral analysis of the target enzyme CYP51 from Penicillium digitatum with possible new DMI fungicides

(2010) Jianhua Zhang et al.   PEST MANAGEMENT SCIENCE

Molecular insights into fungicide resistance in sensitive and resistant Penicillium digitatum strains infecting citrus

(2010) Paloma Sánchez-Torres et al.   POSTHARVEST BIOLOGY AND TECHNOLOGY

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

(2010) N. V. Dharia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation

(2009) Dominique Sanglard et al.   FEMS YEAST RESEARCH

A Gain-of-Function Mutation in the Transcription Factor Upc2p Causes Upregulation of Ergosterol Biosynthesis Genes and Increased Fluconazole Resistance in a ClinicalCandida albicansIsolate

(2008) Nico Dunkel et al.   EUKARYOTIC CELL

Cytoplasmic localization of sterol transcription factors Upc2p and Ecm22p in S. cerevisiae

(2008) Chelsea Marie et al.   FUNGAL GENETICS AND BIOLOGY

Agrobacterium tumefaciens-mediated genetic transformation of the phytopathogenic fungus Penicillium digitatum

(2008) Ji-ye Wang et al.   Journal of Zhejiang University-SCIENCE B

Mutations in the multi-drug resistance regulatorMRR1, followed by loss of heterozygosity, are the main cause ofMDR1overexpression in fluconazole-resistantCandida albicansstrains

(2008) Nico Dunkel et al.   MOLECULAR MICROBIOLOGY

A Sterol-Regulatory Element Binding Protein Is Required for Cell Polarity, Hypoxia Adaptation, Azole Drug Resistance, and Virulence in Aspergillus fumigatus

(2008) Sven D. Willger et al.   PLoS Pathogens