A Small Molecule Inhibitor of ETV1, YK-4-279, Prevents Prostate Cancer Growth and Metastasis in a Mouse Xenograft Model

Single Enantiomer of YK-4-279 Demonstrates Specificity in Targeting the Oncogene EWS-FLI1

(2015) Julie S. Barber-Rotenberg et al.   Oncotarget

Pharmacokinetic modeling optimizes inhibition of the ‘undruggable’ EWS-FLI1 transcription factor in Ewing Sarcoma

(2015) Sung-Hyeok Hong et al.   Oncotarget

Molecular Subtyping of Primary Prostate Cancer Reveals Specific and Shared Target Genes of Different ETS Rearrangements

(2015) Paula Paulo et al.   NEOPLASIA

ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients

(2013) E. Baena et al.   GENES & DEVELOPMENT

ETS factors reprogram the androgen receptor cistrome and prime prostate tumorigenesis in response to PTEN loss

(2013) Yu Chen et al.   NATURE MEDICINE

Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma

(2012) T. J. Grant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts

(2012) X. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic and Biochemical Insights into the Specificity of ETS Transcription Factors

(2011) Peter C. Hollenhorst et al.   Annual Review of Biochemistry

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion-Positive Prostate Cancer

(2011) J. Chad Brenner et al.   CANCER CELL

YK-4-279 Inhibits ERG and ETV1 Mediated Prostate Cancer Cell Invasion

(2011) Said Rahim et al.   PLoS One

Competitive inhibition of transcription factors by small interfering peptides

(2011) Pil Joon Seo et al.   TRENDS IN PLANT SCIENCE

The Clinical Relevance of Molecular Genetics in Soft Tissue Sarcomas

(2010) José Luis Ordóñez et al.   ADVANCES IN ANATOMIC PATHOLOGY

Poly(ADP-Ribose) Polymerase Inhibitors

(2010) Elaina M. Gartner et al.   CANCER JOURNAL

Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo

(2010) Gong-Hong Wei et al.   EMBO JOURNAL

Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis

(2009) Jennifer C King et al.   NATURE GENETICS

Aberrant ERG expression cooperates with loss of PTEN to promote cancer progression in the prostate

(2009) Brett S Carver et al.   NATURE GENETICS

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma

(2009) Hayriye V Erkizan et al.   NATURE MEDICINE

Truncated ETV1, Fused to Novel Tissue-Specific Genes, and Full-Length ETV1 in Prostate Cancer

(2008) K. G. Hermans et al.   CANCER RESEARCH